A new kind of vitamin B(12) coenzyme analogues-2', 5' dideoxycyticobinamide (2' dAdoCbi), 5'-deoxythmidylcobinamide (ThyCbi) and 2', 5' -dideoxycytidylcobinamide (2' dCytCbi) were synthesiz...A new kind of vitamin B(12) coenzyme analogues-2', 5' dideoxycyticobinamide (2' dAdoCbi), 5'-deoxythmidylcobinamide (ThyCbi) and 2', 5' -dideoxycytidylcobinamide (2' dCytCbi) were synthesized by a new route in which deoxynucleosidylcobalamins directly reacted with freshly prepared Ce (OH)3 to remove the di -methylbezimidazole (DBZM) nucleotide. All cobinamides containing 2'-deoxynucleosides were character lied by UV-Vis and 1H NMR spectroscopy.展开更多
The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates th...The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates the cleavage of Co-C bond during the reduchon process.展开更多
Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transorm...Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy展开更多
文摘A new kind of vitamin B(12) coenzyme analogues-2', 5' dideoxycyticobinamide (2' dAdoCbi), 5'-deoxythmidylcobinamide (ThyCbi) and 2', 5' -dideoxycytidylcobinamide (2' dCytCbi) were synthesized by a new route in which deoxynucleosidylcobalamins directly reacted with freshly prepared Ce (OH)3 to remove the di -methylbezimidazole (DBZM) nucleotide. All cobinamides containing 2'-deoxynucleosides were character lied by UV-Vis and 1H NMR spectroscopy.
文摘The electrochemical reduction of alkylaquabis (dimethylglyoximato)Cobalt(Ⅲ) in the absence and presence of β-Cyclodextrin (β-CD) was inveingated by means of cylic voltammetry. It was found that β-CD facilitates the cleavage of Co-C bond during the reduchon process.
文摘Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy
