陕西省宁强县小燕子沟金矿床开采技术条件分析

陕西省宁强县小燕子沟金矿床为近年来在西秦岭地区发现的金矿床。本文对矿区水文、工程、环境地质条件进行分析,认为小燕子沟金矿床水文地质条件为简单-中等类型、工程地质条件复杂程度为中等、环境地质条件为中等,基本适宜矿山建设。研究成果可为后期的矿山开采建设提供基础资料。

用于实时皮肤创面愈合的超强工程化蛋白凝聚体黏合剂

Adhesives have attracted a great deal of attention as an advanced modality in biomedical engineering because of their unique wound management behavior.However,it is a grand challenge for current adhesive systems to achieve robust adhesion due to their tenuous interfacial bonding strength.Moreover,the absence of dynamic adaptability in conventional chemical adhesives restricts neoblasts around the wound from migrating to the site,resulting in an inferior tissue-regeneration effect.Herein,an extracellular matrix-derived biocomposite adhesive with robust adhesion and a real-time skin healing effect is well-engineered.Liquid–liquid phase separation is well-harnessed to drive the assembly of the biocomposite adhesive,with the active involvement of supramolecular interactions between chimeric protein and natural DNA,leading to a robustly reinforced adhesion performance.The bioadhesive exhibits outstanding adhesion and sealing behaviors,with a sheared adhesion strength of approximately 18 MPa,outperforming its reported counterparts.Moreover,the engineered bioderived components endow this adhesive material with biocompatibility and exceptional biological functions including the promotion of cell proliferation and migration,such that the use of this material eventually yields real-time in situ skin regeneration.This work opens up novel avenues for functionalized bioadhesive engineering and biomedical translations.

甘肃大店沟金矿床剥蚀程度及深部找矿方向

大店沟金矿位于甘肃省陇南市北东部,是近年来新发现的中型金矿床,为评价矿床深部资源潜力及找矿方向,本文在分析矿体产出状态、矿化类型垂向变化等特征的基础上,结合矿体黄铁矿热电性剥蚀率定量计算,确定大店沟金矿总体剥蚀率73.69%,表明中上部遭受了较大程度的剥蚀,但深部仍有一定找矿前景和资源潜力。矿床北东段剥蚀程度较大,而南西段剥蚀程度相对较小,为下一步找矿重点方向。

西秦岭地区大店沟金矿体特征及矿体圈连问题讨论

矿体的圈连是矿产勘查的重要环节,是资源储量估算的基础,直接影响资源储量计算结果的正确性和可靠性,并对采矿方法选用有重要影响。本文通过对大店沟金矿床矿体空间状态分析及生产探矿过程中平行矿脉的圈连对比、分析,结合探矿工程验证总结,对大店沟金矿床平行矿体圈连应注意几个问题,进行讨论。

射频消融术后应用奥沙利铂、替吉奥治疗中晚期肝癌的疗效及对血清CXCL13及LTBP2的影响

目的:探究射频消融术后应用奥沙利铂、替吉奥治疗中晚期肝癌的疗效及对血清CXCL13及LTBP2的影响。方法:选择2015年3月至2016年7月在我院接受治疗的80例中晚期肝癌患者为研究对象,采用随机数字分法分为观察组(射频消融联合奥沙利铂及替吉奥化疗组)与对照组(射频消融联合奥沙利铂组),每组各40例。两组患者均给予射频消融术治疗,对照组术后给予奥沙利铂化疗,观察组术后给予奥沙利铂联合替吉奥治疗。观察比较两组患者术后肿瘤消融率以及临床疗效,采用酶联免疫法检测患者治疗前后血清CXCL13及LTBP2水平,依据欧洲癌症研究治疗组织系统开发的癌症病人生活质量测定量表体系中的核心量表(Quality of Life Questionnaire,QLQ-C30),评估患者术前以及术后的生存质量,记录两组不良反应发生情况,定期对患者进行随访,评估远期预后。结果:两组患者术后肿瘤消除率无明显差异(P=0.556),观察组治疗有效率(75.00%)明显高于对照组(52.50%),差异具有统计学意义(P=0.036);治疗前,两组患者血清CXCL13及LTBP2表达水平比较差异无统计学意义(P> 0.05),治疗后两组血清CXCL13及LTBP2水平较治疗前均明显下降,且观察组显著低于对照组(P <0.05);治疗后,患者躯体功能、角色功能、社会功能、情绪功能、认知功能以及整体生活质量评分明显高于治疗前(P <0.05),并且观察组明显高于对照组(P <0.05)。两组患者不良反应率无明显差异(25.00%vs 30.00%,P=0.617)。观察组患者肺癌复发与转移的发生率均明显低于对照组(P <0.05)。结论:射频消融术后应用奥沙利铂、替吉奥可有效治疗中晚期肝癌,提高患者生存质量,抑制肿瘤复发转移,降低血清CXCL13及LTBP2水平,提高患者远期生存率。

射频消融和手术切除在原发性小肝癌患者中的安全性和有效性研究

目的比较射频消融和手术切除在原发性小肝癌患者中的安全性和有效性。方法选取2015年1月—2016年6月自贡市第四人民医院收治的原发性小肝癌120例,按照治疗方法分为观察组和对照组,每组60例。观察组给予射频消融治疗,对照组给予手术切除,观察2组近远期效果。结果观察组住院时间短于对照组(P<0.05);观察组术后1、6月时健康相关的生存质量(SF-36)高于对照组(P<0.05)。观察组总不良反应发生率低于对照组(P<0.05)。2组术后1年时疗效比较差异无统计学意义(P<0.05)。2组术后12、24、36个月时复发率、病死率比较差异均无统计学意义(P>0.05)。结论射频消融可显著改善原发性小肝癌患者近期生活质量,不增加其术后复发率。

Contribution of Hydrogen-Bond Nanoarchitectonics to Switchable Photothermal-Mechanical Properties of Bioinorganic Fibers

Stimuli-responsive materials hold great potential for the development of smart materials due to their specifically tailored characteristics.However,it is challenging to understand internal molecular dynamics when the macroscopic mechanics of materials change in response to specific applied stimuli.Herein,we present the biological composite fibers of which mechanical properties can be reversibly controlled on demand by photothermal effect of an alternating near-infrared light irradiation.In stark contrast to the weakening of the mechanical properties of conventional materials by heating,the mechanical performance of the obtained fibers are significantly enhanced,showing an increase of Young’s modulus by a factor of four.The outstanding photothermal-mechanical behavior relies on the evolution of hydrogen bonds within the system.We envision that this type of fiber material will inspire a new strategy for the construction of smart devices.

鲨鱼盾鳞仿生表面单元结构优化及减阻性能研究

为了进一步提升鲨鱼盾鳞仿生表面的减阻效果,开展鲨鱼盾鳞的单元结构参数优化设计。设计鲨鱼盾鳞仿生表面的单元结构模型,根据微结构尺寸无量纲公式计算单元结构参数的基本取值范围,采用数值模拟方法分析不同参数对减阻效果的影响,根据分析结果获得最佳的单元结构参数组合,通过数值模拟分析排布方式对减阻效果的影响。数值模拟结果表明,在1~9 m/s内,不同结构参数的鲨鱼盾鳞仿生表面均有减阻效果,其中当肋条角度为θ=75°、肋条宽度d=0.1 mm、肋条间距H=2 mm,表面减阻效果最好,减阻率最高可达到22.25%。盾鳞结构能够减缓边界层速度的增加,提高边界层流动的稳定性,最终实现减阻效果。