We synthesized Deltorphin I, Deltorphin II, and their L-Alanine analogs at position 2. The synthesis was carried out with SPPS and Boc strategy. The data, we got from FAB MS, AAA and sequence analysis were in agreemen...We synthesized Deltorphin I, Deltorphin II, and their L-Alanine analogs at position 2. The synthesis was carried out with SPPS and Boc strategy. The data, we got from FAB MS, AAA and sequence analysis were in agreement with the calculated values. We studied the 2D NMR for Deltorphin II and [L-Ala(2)]Deltorphin II in DMSO solution. The H-1-H-1 COSY and 2D NOESY spectra were resolved by computer treatment. The conformations of C-fragment tetrapeptides of Deltorphin II and its L-Ala analog might form a 3(10) alpha -helix. The molecular models of these two peptides were established.展开更多
文摘We synthesized Deltorphin I, Deltorphin II, and their L-Alanine analogs at position 2. The synthesis was carried out with SPPS and Boc strategy. The data, we got from FAB MS, AAA and sequence analysis were in agreement with the calculated values. We studied the 2D NMR for Deltorphin II and [L-Ala(2)]Deltorphin II in DMSO solution. The H-1-H-1 COSY and 2D NOESY spectra were resolved by computer treatment. The conformations of C-fragment tetrapeptides of Deltorphin II and its L-Ala analog might form a 3(10) alpha -helix. The molecular models of these two peptides were established.
