Advances in Journal of Geriatric Cardiology over the course of a decade

The Journal of Geriatric Cardiology(JGC,ISSN 1671-5141/CN 11-5329/R)is a monthly,open-access,international,and peer-reviewed journal sponsored and published by the Institute of Geriatric Cardiology affiliated with Chinese PLA General Hospital.It was created in 2004 by Prof.Shi-Wen WANG,and as the current editor-in-chief,Prof.Yun-Dai CHEN has been involved in JGC for eight years and has achieved impressive advancements.

Professor Da-Yi Hu

Professor Da-Yi Hu (Figure 1) was born in Henan province of central China, in 1946.He graduated from the Beijing Medical School (now Peking University Health Science Center) in 1970 and furthered his education both at SUNY-Oswego and University of Illinois from 1985 to 1987.Professor Hu has been a pioneer in the field of radio-frequency ablation technology in the treatment of tachyarrhythmia.Since 1980, he had actively shared his work with more than 160 hospitals in China along with several hospitals in India, Vietnam and Japan.He has specialized in preventive cardiology, electrophysiology, pacemaker implantation and interventional therapy of coronary artery disease.He also focuses on the treatment and prevention of hypertension, coronary heart disease, heart failure and arrhythmias.He has been recognized with mutiple awards for his outstanding clinical, academic and social service work, such as 'National Prize for Progress in Science and Technology' (twice), 'Chinese Physicians Award' and 'Beijing Advanced Science Workers', to name a few.Currently, he actively participates in the management and prevention of cardiovascular disease and comprehensive interdisciplinary research at a national level.He is the principal investigator of dozens of clinical trials initiated and conducted in the Chinese Mainland, including the China Heart Survey.He has also served at the Steering Committee in many international clinical trials such as ROCKET, BEAUTIFUL, GARFIELD, SHIFIT, SAVE, ACE, MAGELLAN, SIGNIFY, ALECARDIO, Dal-HEART, TIMI54, etc.

Dopamine D2 receptors in the dorsomedial prefrontal cortex modulate social hierarchy in male mice

Social hierarchy greatly influences behavior and health.Both human and animal studies have signaled the medial prefrontal cortex(mPFC)as specifically related to social hierarchy.Dopamine D1 receptors(D1Rs)and D2 receptors(D2Rs)are abundantly expressed in the mPFC,modulat-ing its functions.However,it is unclear how DR-expressing neurons in the mPFC regulate social hierarchy.Here,using a confrontation tube test,we found that most adult C57BL/6J male mice could establish a linear social rank after 1 week of cohabitation.Lower rank individuals showed social anxiety together with decreased serum testosterone levels.D2R expression was significantly downregulated in the dorsal part of mPFC(dmPFC)in lower rank individuals,whereas D1R expression showed no significant difference among the rank groups in the whole mPFC.Virus knockdown of D2Rs in the dmPFC led to mice being particularly prone to lose the contests in the confrontation tube test.Finally,simultaneous D2R activation in the subordinates and D2R inhibition in the dominants in a pair switched their dominant-subordinate relationship.The above results indicate that D2Rs in the dmPFC play an important role in social dominance.Our findings provide novel insights into the divergent func-tions of prefrontal D1Rs and D2Rs in social dominance,which may contribute to ameliorating social dysfunctions along with abnormal social hierarchy.