With the Food and Drug Administration designation in 2017 of 3,4-methylenedioxymethamphetamine(MDMA)as a breakthrough therapy in post-traumatic stress disorder and psilocybin in treatment-resistant depression,psychede...With the Food and Drug Administration designation in 2017 of 3,4-methylenedioxymethamphetamine(MDMA)as a breakthrough therapy in post-traumatic stress disorder and psilocybin in treatment-resistant depression,psychedelic drugs have continued to garner the attention of researchers and clinicians for their promise of unmatched,rapid improvement in a multitude of psychiatric conditions.Classic psychedelic drugs including psilocybin,lysergic acid diethylamide,and ayahuasca,as well as non-classic drugs such as MDMA and ketamine,are currently being investigated for a potential therapeutic role in trauma,depressive disorders,and other psychopathologies.However,psilocybin and MDMA each have a functional profile well-suited for integration with psychotherapy.The present review focuses on psilocybin and MDMA in psychedelic-assisted therapy(PAT),as these studies compose most of the literature pool.In this review,we discuss the current and future uses of psychedelic drugs,with an emphasis on the role of MDMA and psilocybin in PAT in the setting of trauma and related comorbidities on the efficacy of psychedelic drugs across multiple psychiatric disorders.The article concludes with thoughts for future research,such as incorporating wearables and standardization of symptom scales,therapy styles,and assessment of adverse drug reactions.展开更多
Social media has redesigned the landscape of human interaction,and data obtained through these platforms are promising for schizophrenia diagnosis and management.Recent research shows mounting evidence that machine le...Social media has redesigned the landscape of human interaction,and data obtained through these platforms are promising for schizophrenia diagnosis and management.Recent research shows mounting evidence that machine learning analysis of social media content is capable of not only differentiating schizophrenia patients from healthy controls,but also predicting conversion to psychosis and symptom exacerbations.Novel platforms such as Horyzons show promise for improving social functioning and providing timely access to therapeutic resources.Social media is also a considerable means to assess and lessen the stigma surrounding schizophrenia.Herein,the relevant literature pertaining to social media and its clinical applications in schizophrenia over the past five years are summarized,followed by a discussion centered on user feedback to highlight future directions.Social media provides valuable contributions to a multifaceted digital phenotype that may improve schizophrenia care in the near future.展开更多
文摘With the Food and Drug Administration designation in 2017 of 3,4-methylenedioxymethamphetamine(MDMA)as a breakthrough therapy in post-traumatic stress disorder and psilocybin in treatment-resistant depression,psychedelic drugs have continued to garner the attention of researchers and clinicians for their promise of unmatched,rapid improvement in a multitude of psychiatric conditions.Classic psychedelic drugs including psilocybin,lysergic acid diethylamide,and ayahuasca,as well as non-classic drugs such as MDMA and ketamine,are currently being investigated for a potential therapeutic role in trauma,depressive disorders,and other psychopathologies.However,psilocybin and MDMA each have a functional profile well-suited for integration with psychotherapy.The present review focuses on psilocybin and MDMA in psychedelic-assisted therapy(PAT),as these studies compose most of the literature pool.In this review,we discuss the current and future uses of psychedelic drugs,with an emphasis on the role of MDMA and psilocybin in PAT in the setting of trauma and related comorbidities on the efficacy of psychedelic drugs across multiple psychiatric disorders.The article concludes with thoughts for future research,such as incorporating wearables and standardization of symptom scales,therapy styles,and assessment of adverse drug reactions.
文摘Social media has redesigned the landscape of human interaction,and data obtained through these platforms are promising for schizophrenia diagnosis and management.Recent research shows mounting evidence that machine learning analysis of social media content is capable of not only differentiating schizophrenia patients from healthy controls,but also predicting conversion to psychosis and symptom exacerbations.Novel platforms such as Horyzons show promise for improving social functioning and providing timely access to therapeutic resources.Social media is also a considerable means to assess and lessen the stigma surrounding schizophrenia.Herein,the relevant literature pertaining to social media and its clinical applications in schizophrenia over the past five years are summarized,followed by a discussion centered on user feedback to highlight future directions.Social media provides valuable contributions to a multifaceted digital phenotype that may improve schizophrenia care in the near future.
