Although solar exposure is necessary for human health,phototoxicology induced by excessive UVB and UVA radiation,which involves sunburns,skin aging and even tu-morigenesis,has been widely researched.Sunscreen is one o...Although solar exposure is necessary for human health,phototoxicology induced by excessive UVB and UVA radiation,which involves sunburns,skin aging and even tu-morigenesis,has been widely researched.Sunscreen is one of the most important ways to protect skin from UV phototoxic damage.As well as inorganic and organic UV filters,some natural products or plant extracts with aromatic rings in their structures,such as flavonoids or polyphenols,can absorb UV to reduce sunburn,acting as a natu-ral UV filter;they also show antioxidant or/and anti-inflammatory activity.This could explain why,although there are no officially approval natural commercial sun-filters,more and more commercial sunscreen products containing plant extracts are avail-able on the market.Here we summarize articles focusing on natural UV filters from plant published in the last 6 years,selecting the most significant data in order to better understand the photoprotective activity of natural products and extracts from plants,including their major constituents and main biological effects,methods for evaluating UV radiation resistance,anti-UV radiation experimental models and anti-UV radiation mechanisms.展开更多
目的应用高通量测序技术(next generation sequencing,NGS)检测流产胚胎组织染色体拷贝数变异(copy number variations,CNVs)异常,明确不良妊娠的遗传学病因.方法应用NGS技术对流产组织CNVs异常进行检测,结合胚胎组织CNVs结果推测亲代核...目的应用高通量测序技术(next generation sequencing,NGS)检测流产胚胎组织染色体拷贝数变异(copy number variations,CNVs)异常,明确不良妊娠的遗传学病因.方法应用NGS技术对流产组织CNVs异常进行检测,结合胚胎组织CNVs结果推测亲代核型,通过G显带核型分析、荧光原位杂交技术(fluorescence in situ hybridization,FISH)对亲代染色体异常片段进行精准定位.结果除检测到染色体数目异常外,检测到染色体微缺失/微重复12例,在亲代进行了染色体核型分析的8个家系中,4个的亲代之一存在染色体异常,包括1例以往染色体核型分析漏诊的标记染色体携带者及1例经FISH检测证实为隐匿性平衡易位携带者.结论通过CNVs检测,可辅助诊断不良孕产史夫妇隐匿性染色体微小片段结构异常,在其遗传学诊断中具有重要的应用价值.展开更多
基金supported by Henan Provincial Department of Education(No.21B350001)Zhengzhou science and technology department(No.ZZSZX202109 and ZZSZX202108).
文摘Although solar exposure is necessary for human health,phototoxicology induced by excessive UVB and UVA radiation,which involves sunburns,skin aging and even tu-morigenesis,has been widely researched.Sunscreen is one of the most important ways to protect skin from UV phototoxic damage.As well as inorganic and organic UV filters,some natural products or plant extracts with aromatic rings in their structures,such as flavonoids or polyphenols,can absorb UV to reduce sunburn,acting as a natu-ral UV filter;they also show antioxidant or/and anti-inflammatory activity.This could explain why,although there are no officially approval natural commercial sun-filters,more and more commercial sunscreen products containing plant extracts are avail-able on the market.Here we summarize articles focusing on natural UV filters from plant published in the last 6 years,selecting the most significant data in order to better understand the photoprotective activity of natural products and extracts from plants,including their major constituents and main biological effects,methods for evaluating UV radiation resistance,anti-UV radiation experimental models and anti-UV radiation mechanisms.
文摘目的应用高通量测序技术(next generation sequencing,NGS)检测流产胚胎组织染色体拷贝数变异(copy number variations,CNVs)异常,明确不良妊娠的遗传学病因.方法应用NGS技术对流产组织CNVs异常进行检测,结合胚胎组织CNVs结果推测亲代核型,通过G显带核型分析、荧光原位杂交技术(fluorescence in situ hybridization,FISH)对亲代染色体异常片段进行精准定位.结果除检测到染色体数目异常外,检测到染色体微缺失/微重复12例,在亲代进行了染色体核型分析的8个家系中,4个的亲代之一存在染色体异常,包括1例以往染色体核型分析漏诊的标记染色体携带者及1例经FISH检测证实为隐匿性平衡易位携带者.结论通过CNVs检测,可辅助诊断不良孕产史夫妇隐匿性染色体微小片段结构异常,在其遗传学诊断中具有重要的应用价值.
