Multiple sclerosis(MS)is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be com...Multiple sclerosis(MS)is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be completely eradicated.Thus,there might be unknown factors capable of regulating the vitamin D receptor(VDR).Genome-wide analysis showed that miRNAs were associated with VDRs.We sought to determine the role and mechanism of action of miRNA-125a-5p and VDRs in a model of MS,mice with experimental autoimmune encephalomyelitis(EAE),which was induced by myelin oligodendrocyte glycoprotein 35–55 peptides.EAE mice showed decreased mean body weight but increased mean clinical scores compared with vehicle or control mice.And inflammatory infiltration was found in the lumbosacral spinal cord of EAE mice.In addition,VDR expression was significantly lower while the expression of miR-125a-5p was markedly higher in the spinal ventral horn of EAE mice than in vehicle or control mice.Importantly,activation of VDRs by paricalcitol or inhibition of miR-125a-5p by its antagomir markedly decreased the mean clinical scores in EAE mice.Interestingly,VDR and miR-125a-5p were co-localized in the same neurons of the ventral horn.More importantly,inhibition of miR-125a-5p remarkably blocked the decrease of VDRs in EAE mice.These results support a critical role for miR-125a-5p in modulating VDR activity in EAE and suggest potential novel therapeutic interventions.展开更多
To the Editor:In the last recent years,significant progress has been achieved in research on dysphagia.This is important because approximately 50% of patients with dysphagia after acute stroke still have a slow functi...To the Editor:In the last recent years,significant progress has been achieved in research on dysphagia.This is important because approximately 50% of patients with dysphagia after acute stroke still have a slow functional recovery,and the duration of disease may last for several months or the whole life.The ultimate aim of dysphagia treatment is for patients to be able to eat again and to examine if the influence of eating conditions is inevitable in dysphagia research.展开更多
To the Editor:Rasmussen encephalitis(RE)is a chronic inflammatory disease of unknown origin,which usually affects one hemisphere of the brain.[1]It is an uncommon disease of the nervous system that is usually seen in ...To the Editor:Rasmussen encephalitis(RE)is a chronic inflammatory disease of unknown origin,which usually affects one hemisphere of the brain.[1]It is an uncommon disease of the nervous system that is usually seen in children.While the cause of RE is unknown,current evidence suggests that autoimmune processes are responsible for the damage to the brain cells.Because of repeated convulsions and progressive neuronal damage,patients often suffer from mental decline and neurological impairment.A 12-year-old girl presented to the hospital with a paroxysmal left limb twitching and exacerbation of left limb weakness.She was apparently well until October 2004 when she had the first episode.Later on,she gradually developed paroxysmal involuntary tremors in the left lower extremity,a few seconds each time,2 to 3 times per day.She has consciousness,no headache,nausea,vomiting,binocular gaze,fatigue,and so on.In December 2004,the patient suddenly lost consciousness during the class and fell to the ground with limb tetanic convulsions,binocular gaze,no incontinence,and bite of tongue.展开更多
基金supported by the International Science and Technology Cooperation Plan of Guizhou Province,China[(2013)7027]the National Natural Science Foundation of China(81471137 and 31730040).
文摘Multiple sclerosis(MS)is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be completely eradicated.Thus,there might be unknown factors capable of regulating the vitamin D receptor(VDR).Genome-wide analysis showed that miRNAs were associated with VDRs.We sought to determine the role and mechanism of action of miRNA-125a-5p and VDRs in a model of MS,mice with experimental autoimmune encephalomyelitis(EAE),which was induced by myelin oligodendrocyte glycoprotein 35–55 peptides.EAE mice showed decreased mean body weight but increased mean clinical scores compared with vehicle or control mice.And inflammatory infiltration was found in the lumbosacral spinal cord of EAE mice.In addition,VDR expression was significantly lower while the expression of miR-125a-5p was markedly higher in the spinal ventral horn of EAE mice than in vehicle or control mice.Importantly,activation of VDRs by paricalcitol or inhibition of miR-125a-5p by its antagomir markedly decreased the mean clinical scores in EAE mice.Interestingly,VDR and miR-125a-5p were co-localized in the same neurons of the ventral horn.More importantly,inhibition of miR-125a-5p remarkably blocked the decrease of VDRs in EAE mice.These results support a critical role for miR-125a-5p in modulating VDR activity in EAE and suggest potential novel therapeutic interventions.
文摘To the Editor:In the last recent years,significant progress has been achieved in research on dysphagia.This is important because approximately 50% of patients with dysphagia after acute stroke still have a slow functional recovery,and the duration of disease may last for several months or the whole life.The ultimate aim of dysphagia treatment is for patients to be able to eat again and to examine if the influence of eating conditions is inevitable in dysphagia research.
文摘To the Editor:Rasmussen encephalitis(RE)is a chronic inflammatory disease of unknown origin,which usually affects one hemisphere of the brain.[1]It is an uncommon disease of the nervous system that is usually seen in children.While the cause of RE is unknown,current evidence suggests that autoimmune processes are responsible for the damage to the brain cells.Because of repeated convulsions and progressive neuronal damage,patients often suffer from mental decline and neurological impairment.A 12-year-old girl presented to the hospital with a paroxysmal left limb twitching and exacerbation of left limb weakness.She was apparently well until October 2004 when she had the first episode.Later on,she gradually developed paroxysmal involuntary tremors in the left lower extremity,a few seconds each time,2 to 3 times per day.She has consciousness,no headache,nausea,vomiting,binocular gaze,fatigue,and so on.In December 2004,the patient suddenly lost consciousness during the class and fell to the ground with limb tetanic convulsions,binocular gaze,no incontinence,and bite of tongue.
