Cell-material interactions are important to tissue engineering.Inspired by the natural topographic structures on the extracellular matrix,a growing number of studies have integrated engineering topography into investi...Cell-material interactions are important to tissue engineering.Inspired by the natural topographic structures on the extracellular matrix,a growing number of studies have integrated engineering topography into investigations of cell behavior on biomaterials.Engineering topography has a significant influence on cell behaviors.These cell-topography interactions play an important role in regenerative medicine and tissue engineering.Similarly,cell-topography interactions are important to corneal reconstruction and regeneration.In this review,we primarily summarized the effects of topographic cues on the behaviors of corneal cells,including cell morphology,adhesion,migration,and proliferation.Furthermore,the integration of engineering surface topography into corneal tissue engineering was also discussed.展开更多
基金the financial support provided by the National Natural Science Foundation of China(51273072,51603074,31971261)the Natural Science Foundation of Guangdong Province(2017A030313294)+2 种基金The National Key Research and Development Program of China(2017YFC1105004)the Guangdong Scientific and Technological Project(2014B090907004,201508020123Medical Scientific Research Foundation of Guangdong Province(A2018169).
文摘Cell-material interactions are important to tissue engineering.Inspired by the natural topographic structures on the extracellular matrix,a growing number of studies have integrated engineering topography into investigations of cell behavior on biomaterials.Engineering topography has a significant influence on cell behaviors.These cell-topography interactions play an important role in regenerative medicine and tissue engineering.Similarly,cell-topography interactions are important to corneal reconstruction and regeneration.In this review,we primarily summarized the effects of topographic cues on the behaviors of corneal cells,including cell morphology,adhesion,migration,and proliferation.Furthermore,the integration of engineering surface topography into corneal tissue engineering was also discussed.
