Aim:The oxidized low-density lipoprotein(OxLDL) plays an important role in atherosclerosis yet it remains unclear if it damages circulating erythrocytes. Method: In this study。
Erythrocyte tropomodulin（E-Tmod）is a capping protein at the slow-growing end of the actin filaments and regulates the length of the junctional complex in the erythrocyte membrane skeleton<sup>[1]</sup>.E...Erythrocyte tropomodulin（E-Tmod）is a capping protein at the slow-growing end of the actin filaments and regulates the length of the junctional complex in the erythrocyte membrane skeleton<sup>[1]</sup>.E-Tmod has two alternative promoters,P<sub>E0</sub>,and P<sub>E1</sub>,upstream of exons EO and E1,respectively.They drive the expression of two E-Tmod isoforms,E-Tmod41 and ETmod29,which play different yet coordinated roles in cytoskeleton reorganization<sup>[2]</sup>.This study aimed at investigating the expessions of the two E-Tmod isoforms response to the mechanical stresses,i.e.,shear stress and hydrostatic pressure.A cone-plate flow system and a hydrostatic pressure device were developed.Murine erythroleukemia（MEL）cells were subjected展开更多
基金supported by National Natural Science Foundation of China(NSFC10572159)supported by "111 Project" entitled "Biomechanics&Tissue Repair Engineering"(No.:B06023)Chongqing Science&Technology Council(CSTC 2006ba5010)
文摘Aim:The oxidized low-density lipoprotein(OxLDL) plays an important role in atherosclerosis yet it remains unclear if it damages circulating erythrocytes. Method: In this study。
基金supported by Natural Science Foundation of China(No.31170886)
文摘Erythrocyte tropomodulin（E-Tmod）is a capping protein at the slow-growing end of the actin filaments and regulates the length of the junctional complex in the erythrocyte membrane skeleton<sup>[1]</sup>.E-Tmod has two alternative promoters,P<sub>E0</sub>,and P<sub>E1</sub>,upstream of exons EO and E1,respectively.They drive the expression of two E-Tmod isoforms,E-Tmod41 and ETmod29,which play different yet coordinated roles in cytoskeleton reorganization<sup>[2]</sup>.This study aimed at investigating the expessions of the two E-Tmod isoforms response to the mechanical stresses,i.e.,shear stress and hydrostatic pressure.A cone-plate flow system and a hydrostatic pressure device were developed.Murine erythroleukemia（MEL）cells were subjected
