To The Editor:Acne vulgaris is a chronic inflammatory skin disease involving the sebaceous glands.It has an incidence of approximately 9.4%,often occurring in adolescents.[1]The disease itself and the scars left after...To The Editor:Acne vulgaris is a chronic inflammatory skin disease involving the sebaceous glands.It has an incidence of approximately 9.4%,often occurring in adolescents.[1]The disease itself and the scars left after treatment can cause psychological stress in adolescents and seriously affect patients’quality of life.[2]At present,skin care products,either alone or in combination with medical drugs,have become important means for treating acne.This single-center,single-blind(clinician-blind),masculine-paralleled,randomized study(Registration number:ChiCTR2100051398)evaluated the efficacy and safety of a cream containing octyl salicylic acid,salicylic acid,linoleic acid,nicotinamide,and piroctone olamine(Duo+,La Roche-Posay,Paris,France)alone and in combination with benzoyl peroxide(BPO,Galderma,Paris,France)for the treatment of mild-to-moderate acne.The research was approved by the Ethics Committee of Shanghai Skin Disease Hospital,China(No.2020-13 ke).All participants provided written informed consent.展开更多
Circular RNAs(circRNAs)are a class of single‐stranded closed RNAs that are produced by the back splicing of precursor mRNAs.The formation of circRNAs mainly involves intron‐pairing‐driven circularization,RNA‐bindi...Circular RNAs(circRNAs)are a class of single‐stranded closed RNAs that are produced by the back splicing of precursor mRNAs.The formation of circRNAs mainly involves intron‐pairing‐driven circularization,RNA‐binding protein(RBP)‐driven circularization,and lariat‐driven circularization.The vast majority of circRNAs are found in the cytoplasm,and some intron‐containing circRNAs are localized in the nucleus.CircRNAs have been found to function as microRNA(miRNA)sponges,interact with RBPs and translate proteins,and play an important regulatory role in the development and progression of cancer.CircRNAs exhibit tissue‐and developmental stage–specific expression and are stable,with longer half‐lives than linear RNAs.CircRNAs have great potential as biomarkers for cancer diagnosis and prognosis,which is highlighted by their detectability in tissues,especially in fluid biopsy samples such as plasma,saliva,and urine.Here,we review the current studies on the properties and functions of circRNAs and their clinical application value.展开更多
基金Science and Technology Commission of Shanghai Municipality(No. 20Y11905600)Shanghai Municipal Health Commission(No. 20194Y0337)
文摘To The Editor:Acne vulgaris is a chronic inflammatory skin disease involving the sebaceous glands.It has an incidence of approximately 9.4%,often occurring in adolescents.[1]The disease itself and the scars left after treatment can cause psychological stress in adolescents and seriously affect patients’quality of life.[2]At present,skin care products,either alone or in combination with medical drugs,have become important means for treating acne.This single-center,single-blind(clinician-blind),masculine-paralleled,randomized study(Registration number:ChiCTR2100051398)evaluated the efficacy and safety of a cream containing octyl salicylic acid,salicylic acid,linoleic acid,nicotinamide,and piroctone olamine(Duo+,La Roche-Posay,Paris,France)alone and in combination with benzoyl peroxide(BPO,Galderma,Paris,France)for the treatment of mild-to-moderate acne.The research was approved by the Ethics Committee of Shanghai Skin Disease Hospital,China(No.2020-13 ke).All participants provided written informed consent.
基金Fundamental Research Funds for the Central Universities,Grant/Award Number:3332020023Beijing Hope Run Special Fund of Cancer Foundation of China,Grant/Award Number:LC2019A04+1 种基金National High Level Hospital Clinical Research Funding,Grant/Award Number:BJ-2022-194National Natural Science Foundation of China,Grant/Award Number:81871107。
文摘Circular RNAs(circRNAs)are a class of single‐stranded closed RNAs that are produced by the back splicing of precursor mRNAs.The formation of circRNAs mainly involves intron‐pairing‐driven circularization,RNA‐binding protein(RBP)‐driven circularization,and lariat‐driven circularization.The vast majority of circRNAs are found in the cytoplasm,and some intron‐containing circRNAs are localized in the nucleus.CircRNAs have been found to function as microRNA(miRNA)sponges,interact with RBPs and translate proteins,and play an important regulatory role in the development and progression of cancer.CircRNAs exhibit tissue‐and developmental stage–specific expression and are stable,with longer half‐lives than linear RNAs.CircRNAs have great potential as biomarkers for cancer diagnosis and prognosis,which is highlighted by their detectability in tissues,especially in fluid biopsy samples such as plasma,saliva,and urine.Here,we review the current studies on the properties and functions of circRNAs and their clinical application value.
