Nasopharyngeal carcinoma(NPC)is a disease with unique epidemiology.It is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally...Nasopharyngeal carcinoma(NPC)is a disease with unique epidemiology.It is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally,133,354 NPC cases were diagnosed in 2020 with 80,008;deaths in the same year[2].While the survival rates of early-stage NPC after radiotherapy(RT)are high,dis-ease recurrences are common in locoregionally-advanced NPC,with the predominant pattern of failure being dis-tant metastasis[3].In this clinical scenario,palliative chemotherapy is the primary treatment modality。展开更多
基金supported by the National Medical Research Council Singapore Clinician Scientist Award(NMRC/CSA-INV/0027/2018,CSAINV20nov-0021),the Duke-NUS Oncology Academic Program Goh Foundation Proton Research Programme,NCCS Cancer Fund,and the Kua Hong Pak Head and Neck Cancer Research Programme.
文摘Nasopharyngeal carcinoma(NPC)is a disease with unique epidemiology.It is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally,133,354 NPC cases were diagnosed in 2020 with 80,008;deaths in the same year[2].While the survival rates of early-stage NPC after radiotherapy(RT)are high,dis-ease recurrences are common in locoregionally-advanced NPC,with the predominant pattern of failure being dis-tant metastasis[3].In this clinical scenario,palliative chemotherapy is the primary treatment modality。
