In the cell,one-carbon metabolism modulates nucleotide synthesis,DNA repair,as well as methylation through the reduction of homocysteine（Figure 1）.High levels of plasma homocysteine have been associated with negativ...In the cell,one-carbon metabolism modulates nucleotide synthesis,DNA repair,as well as methylation through the reduction of homocysteine（Figure 1）.High levels of plasma homocysteine have been associated with negative health outcomes in humans（Murray et al.,2017）.Folates,B-vitamins,are a major component of one-carbon metabolism and play an important role in brain function.Specifically,they are involved in nucleotide synthesis,DNA repair,methylation,second messenger systems,ion channels,protein,展开更多
基金funded by Graduate Award for Ontario Students for Research in Dementiafunded by Canadian Institutes of Health Research(CIHR)Studentshipfunded by the Natural Sciences and Engineering Research Council(NSERC) grant
文摘In the cell,one-carbon metabolism modulates nucleotide synthesis,DNA repair,as well as methylation through the reduction of homocysteine（Figure 1）.High levels of plasma homocysteine have been associated with negative health outcomes in humans（Murray et al.,2017）.Folates,B-vitamins,are a major component of one-carbon metabolism and play an important role in brain function.Specifically,they are involved in nucleotide synthesis,DNA repair,methylation,second messenger systems,ion channels,protein,
