Dear Editor, Plasmacytoid dendritic cells （pDCs） are the professional type I interferon-producing cells of the immune system, which rapidly produce massive amounts of type I interferons （IFN-I） in response to viru...Dear Editor, Plasmacytoid dendritic cells （pDCs） are the professional type I interferon-producing cells of the immune system, which rapidly produce massive amounts of type I interferons （IFN-I） in response to viruses or other nucleic acids Iigands through selectively expressed toll-like receptor （TLR）-7 and TLR9 （Siegal et al., 1999）. The activation of pDCs not only inhibits virus replication, but also regulates the function of other immune cells and links the innate and adaptive immunity （Liu, 2005）. The local accumulation of pDCs has been reported in both suppressive and overactive immune status （Swiecki and Colonna, 2010）, which highlights the importance of characterizing the molecular mechanisms underlying the functional specialization of pDCs in IFN-I production.展开更多
文摘Dear Editor, Plasmacytoid dendritic cells （pDCs） are the professional type I interferon-producing cells of the immune system, which rapidly produce massive amounts of type I interferons （IFN-I） in response to viruses or other nucleic acids Iigands through selectively expressed toll-like receptor （TLR）-7 and TLR9 （Siegal et al., 1999）. The activation of pDCs not only inhibits virus replication, but also regulates the function of other immune cells and links the innate and adaptive immunity （Liu, 2005）. The local accumulation of pDCs has been reported in both suppressive and overactive immune status （Swiecki and Colonna, 2010）, which highlights the importance of characterizing the molecular mechanisms underlying the functional specialization of pDCs in IFN-I production.
