CD8 T cells play critical roles in controlling intracellular pathogensand tumors. To accomplish this the small number of antigen-inexperienced naive CD8 T cells that are capable of recognizing the antigen of interest ...CD8 T cells play critical roles in controlling intracellular pathogensand tumors. To accomplish this the small number of antigen-inexperienced naive CD8 T cells that are capable of recognizing the antigen of interest must first become primed. These initial activaion events occur while the responding T cells are sequestered within lymph nodes, but many of the cells subsequently egress into the periphery and migrate into other organs where they can fulfill their principle mission of identifying and eliminating infected or malignant target cells.展开更多
文摘CD8 T cells play critical roles in controlling intracellular pathogensand tumors. To accomplish this the small number of antigen-inexperienced naive CD8 T cells that are capable of recognizing the antigen of interest must first become primed. These initial activaion events occur while the responding T cells are sequestered within lymph nodes, but many of the cells subsequently egress into the periphery and migrate into other organs where they can fulfill their principle mission of identifying and eliminating infected or malignant target cells.
