Constitutive androstane receptor(CAR)is a nuclear receptor that is encoded by the gene NR113(nuclear receptor subfamily 1 group I member 3)and is almost exclusively expressed in the liver.1 As reported in our recent p...Constitutive androstane receptor(CAR)is a nuclear receptor that is encoded by the gene NR113(nuclear receptor subfamily 1 group I member 3)and is almost exclusively expressed in the liver.1 As reported in our recent publication,CAR is well established as a xenosensor for drugs and energy metabolism with newer implications in the regulation of normal liver physiology and liver regeneration.展开更多
基金supported by the Robert W.Storr Bequest to the Sydney Medical Foundation,University of Sydney,Australia,and the National Health and Medical Research Council of Australia (NHMRC),Australia Program and Investigator Grants (No.AAP2008983,APP1053206,APP1196492)supported by project grants from Cancer Council NSW,Australia (No.APP1145008 to JG and LQ,APP1070076 to CL and LQ),Cancer Institute NSW,Australia grants 15/TRC/1-01 and 2021/ATRG2028,and an NHMRC Program Grant (No.APP1149976 to JG).
文摘Constitutive androstane receptor(CAR)is a nuclear receptor that is encoded by the gene NR113(nuclear receptor subfamily 1 group I member 3)and is almost exclusively expressed in the liver.1 As reported in our recent publication,CAR is well established as a xenosensor for drugs and energy metabolism with newer implications in the regulation of normal liver physiology and liver regeneration.
