Introduction Representing the prevalent primary hepatic malignancy,hepatocellular carcinoma(HCC)is concurrently the sixth most common cancer worldwide and the third dominant cause of mortality due to cancer(1,2).The p...Introduction Representing the prevalent primary hepatic malignancy,hepatocellular carcinoma(HCC)is concurrently the sixth most common cancer worldwide and the third dominant cause of mortality due to cancer(1,2).The preponderance of such neoplasms is secondary to cirrhosis,primarily induced by viral hepatitis,alcohol abuse or exposure to other hepatotoxins.Over the last decades,however,metabolic disorders such as obesity and insulin resistance,have established as key players in the chronic damage of liver parenchyma,eventually contributing to the development of the large spectrum of chronic hepatopathies known as non-alcoholic fatty liver disease(NAFLD)(3).展开更多
文摘Introduction Representing the prevalent primary hepatic malignancy,hepatocellular carcinoma(HCC)is concurrently the sixth most common cancer worldwide and the third dominant cause of mortality due to cancer(1,2).The preponderance of such neoplasms is secondary to cirrhosis,primarily induced by viral hepatitis,alcohol abuse or exposure to other hepatotoxins.Over the last decades,however,metabolic disorders such as obesity and insulin resistance,have established as key players in the chronic damage of liver parenchyma,eventually contributing to the development of the large spectrum of chronic hepatopathies known as non-alcoholic fatty liver disease(NAFLD)(3).
