A two-component lattice Boltzmann method(LBM) with a multiple-relaxation-time(MRT) collision operator is presented to improve the numerical stability of the single relaxation time(SRT) model. The macroscopic and the m...A two-component lattice Boltzmann method(LBM) with a multiple-relaxation-time(MRT) collision operator is presented to improve the numerical stability of the single relaxation time(SRT) model. The macroscopic and the momentum conservation equations can be retrieved through the Chapman–Enskog(C-E) expansion analysis. The equilibrium moment with the diffusion term is calculated, a diffusion phenomenon is simulated by utilizing the developed model, and the numerical stability is verified. Furthermore, the binary mixture channel model is designed to simulate the sound attenuation phenomenon, and the obtained simulation results are found to be consistent with the analytical solutions. The sound attenuation model is used to study the numerical stability and calculation accuracy of the LBM model. The simulation results show the stability and accuracy of the MRT model and the SRT model under different viscosity conditions. Finally,we study the influence of the error between the macroscopic equation of the MRT model and the standard incompressible Navier–Stokes equation on the calculation accuracy of the model to demonstrate the general applicability of the conclusions drawn by the sound attenuation model in the present study.展开更多
Objective:To evaluate the efficacy of Astragalus Injection on asthma.Methods:CNKI,VIP,Wan Fang Database,Medline,Embase,Web of Science and Cochrane Library were searched for published researches up to November,2020.Ran...Objective:To evaluate the efficacy of Astragalus Injection on asthma.Methods:CNKI,VIP,Wan Fang Database,Medline,Embase,Web of Science and Cochrane Library were searched for published researches up to November,2020.Randomized controlled trials that focused on Astragalus Injection for asthma were included.We managed the data analysis with RevMan 5.3 software.Results:A total of 17 RCTs with 1648 patients were involved in the meta-analysis which indicated that Astragalus Injection could improve clinical efficacy[OR=4.72,95%CI(3.08,7.24),P<0.00001]and improve FEV1[MD=0.48,95%CI(0.32,0.64),P<0.00001],while reduce IL-4[MD=-6.29,95%CI(-8.91,-3.66),P<0.00001],IL-6[MD=-18.46,95%CI(-23.17,-13.75),P<0.00001]and IL-17[MD=-3.14,95%CI(-5.51,-0.76),P<0.00001]and decrease adverse events[OR=0.18,95%CI(0.08,0.43),P=0.0001].Conclusion:Astragalus Injection is more effective and of safety,but more RCTs are needed.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 12174085, 11874140, and 11574072)the State Key Laboratory of Acoustics, Chinese Academy of Sciences (Grant No. SKLA201913)the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (Grant No. KYCX21 0478)。
文摘A two-component lattice Boltzmann method(LBM) with a multiple-relaxation-time(MRT) collision operator is presented to improve the numerical stability of the single relaxation time(SRT) model. The macroscopic and the momentum conservation equations can be retrieved through the Chapman–Enskog(C-E) expansion analysis. The equilibrium moment with the diffusion term is calculated, a diffusion phenomenon is simulated by utilizing the developed model, and the numerical stability is verified. Furthermore, the binary mixture channel model is designed to simulate the sound attenuation phenomenon, and the obtained simulation results are found to be consistent with the analytical solutions. The sound attenuation model is used to study the numerical stability and calculation accuracy of the LBM model. The simulation results show the stability and accuracy of the MRT model and the SRT model under different viscosity conditions. Finally,we study the influence of the error between the macroscopic equation of the MRT model and the standard incompressible Navier–Stokes equation on the calculation accuracy of the model to demonstrate the general applicability of the conclusions drawn by the sound attenuation model in the present study.
基金TCM Rehabilitation Program for Respiratory Diseases(COPD,asthma,pulmonary fibrosis,K2017ykf07)Clinical trials+1 种基金Tonifying Kidney and Qi Prescription for Bronchial Asthma with Renal Qi Deficiency(409)Jiangsu"twelfth Five-Year"Key discipline of Traditional Chinese Medicine(JS1302)。
文摘Objective:To evaluate the efficacy of Astragalus Injection on asthma.Methods:CNKI,VIP,Wan Fang Database,Medline,Embase,Web of Science and Cochrane Library were searched for published researches up to November,2020.Randomized controlled trials that focused on Astragalus Injection for asthma were included.We managed the data analysis with RevMan 5.3 software.Results:A total of 17 RCTs with 1648 patients were involved in the meta-analysis which indicated that Astragalus Injection could improve clinical efficacy[OR=4.72,95%CI(3.08,7.24),P<0.00001]and improve FEV1[MD=0.48,95%CI(0.32,0.64),P<0.00001],while reduce IL-4[MD=-6.29,95%CI(-8.91,-3.66),P<0.00001],IL-6[MD=-18.46,95%CI(-23.17,-13.75),P<0.00001]and IL-17[MD=-3.14,95%CI(-5.51,-0.76),P<0.00001]and decrease adverse events[OR=0.18,95%CI(0.08,0.43),P=0.0001].Conclusion:Astragalus Injection is more effective and of safety,but more RCTs are needed.
基金the Support Plan for Overseas Students to Return to China for Entrepreneurship and Innovation(cx2020003)the Fundamental Research Funds for the Central Universities(2020CDJQY-A028 and 2020CDJ-LHZZ-074)the Natural Science Foundation of Chongqing(cstc2020jcyj-msxmX0629)。
