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江西地区不规则抗体致新生儿溶血病回顾性分析 被引量:2
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作者 刘昕 乐芳 +2 位作者 王莲慧 舒锦 徐秀云 《中国实验血液学杂志》 CAS CSCD 北大核心 2023年第1期215-220,共6页
目的:分析ABO以外不规则血型抗体导致的新生儿溶血病(ABO-HDFN)的抗体特异性分布特征、实验室检测情况及其与临床的相关性。方法:选取2012年10月至2021年12月本院送检的非ABO-HDFN病例为研究对象,随机选取同期确诊为ABO-HDFN的病例作为... 目的:分析ABO以外不规则血型抗体导致的新生儿溶血病(ABO-HDFN)的抗体特异性分布特征、实验室检测情况及其与临床的相关性。方法:选取2012年10月至2021年12月本院送检的非ABO-HDFN病例为研究对象,随机选取同期确诊为ABO-HDFN的病例作为对照组,对引起HDFN抗体特异性分布、总胆红素、直抗、母亲孕产史、患儿日龄、有无合并ABO-HDFN、是否换/输血等资料进行回顾性分析,分析江西地区非ABO-HDFN患者的特征。结果:江西地区非ABO-HDFN的检出率逐年升高,187例非ABO-HDFN病例中,检出Rh-HDFN比例最高,为94.6%;与对照组ABO-HDFN相比,非ABO-HDFN的直抗平均积分值更高、总胆红素峰值更高、持续时间长;抗M-HDFN可能出现病情严重但直抗弱阳性/阴性的情况,临床上易被漏检而延误治疗;不规则抗体的特异性、患儿性别、母亲既往生育史、有无合并ABO-HDFN等指标与是否需要换/输血治疗之间均无相关性(P>0.05)。结论:江西地区引起非ABO-HDFN的不规则抗体以Rh血型系统为主,MNS血型系统次之。了解HDFN疾病的特征、血清学特点及与临床指标的相关性,将有助于及时发现、治疗非ABO-HDFN,降低并发症危害。 展开更多
关键词 新生儿溶血病 RH血型抗体 MNS血型抗体 Kidd血型抗体
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Scaling law of resolved-scale isotropic turbulence and its application in large-eddy simulation 被引量:6
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作者 le fang Bo Li Li-Peng Lu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2014年第3期339-350,共12页
Eddy-damping quasinormal Markovian (EDQNM) theory is employed to calculate the resolved-scale spectrum and transfer spectrum, based on which we investigate the resolved-scale scaling law. Results show that the scali... Eddy-damping quasinormal Markovian (EDQNM) theory is employed to calculate the resolved-scale spectrum and transfer spectrum, based on which we investigate the resolved-scale scaling law. Results show that the scaling law of the resolved-scale turbulence, which is affected by several factors, is far from that of the full-scale turbulence and should be corrected. These results are then applied to an existing subgrid model to improve its performance. A series of simulations are performed to verify the necessity of a fixed scaling law in the subgrid modeling. 展开更多
关键词 Scaling law Large-eddy simulation CZZSmodel
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Corrections to the scaling of the second-order structure function in isotropic turbulence 被引量:6
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作者 le fang Wouter J. T. Bos +2 位作者 Xiaozhou Zhou Liang Shao Jean-Pierre Bertoglio 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第2期151-157,共7页
The approach of Obukhov assuming a constant skewness was used to obtain analytical corrections to the scaling of the second order structure function, starting from Kolmogorov's 4/5 law. These corrections can be used ... The approach of Obukhov assuming a constant skewness was used to obtain analytical corrections to the scaling of the second order structure function, starting from Kolmogorov's 4/5 law. These corrections can be used in model applications in which explicit expressions, rather than numerical solutions are needed. The comparison with an interpolation formula proposed by Batchelor, showed that the latter gives surprisingly precise results. The modification of the same method to obtain analytical corrections to the scaling law, taking into account the possible corrections induced by intermittency, is also proposed. 展开更多
关键词 Scaling law · Structure function ·Isotropic turbulence
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Non-equilibrium turbulent phenomena in the ?ow over a backward-facing ramp 被引量:1
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作者 le fang Hongkai ZHAO +2 位作者 Weidan NI Jian fang Lipeng LU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2019年第2期215-236,共22页
Non-equilibrium turbulence phenomena have raised great interests in recent years. Significant efforts have been devoted to non-equilibrium turbulence properties in canonical flows, e.g., grid turbulence, turbulent wak... Non-equilibrium turbulence phenomena have raised great interests in recent years. Significant efforts have been devoted to non-equilibrium turbulence properties in canonical flows, e.g., grid turbulence, turbulent wakes, and homogeneous isotropic turbulence(HIT). The non-equilibrium turbulence in non-canonical flows, however, has rarely been studied due to the complexity of the flows. In the present contribution, a directnumerical simulation(DNS) database of a turbulent flow is analyzed over a backwardfacing ramp, the flow near the boundary is demonstrated, and the non-equilibrium turbulent properties of the flow in the wake of the ramp are presented by using the characteristic parameters such as the dissipation coefficient C and the skewness of longitudinal velocity gradient Sk, but with opposite underlying turbulent energy transfer properties. The equation of Lagrangian velocity gradient correlation is examined, and the results show that non-equilibrium turbulence is the result of phase de-coherence phenomena, which is not taken into account in the modeling of non-equilibrium turbulence. These findings are expected to inspire deeper investigation of different non-equilibrium turbulence phenomena in different flow conditions and the improvement of turbulence modeling. 展开更多
关键词 NON-EQUILIBRIUM TURBULENCE BACKWARD RAMP direct numerical simulation(DNS)
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A closure model on velocity structure functions in homogeneous isotropic turbulence
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作者 le fang Feng GAO 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2017年第11期1627-1634,共8页
Closure models started from Chou's work have been developed for more than 70 years, aiming at providing analytical tools to describe turbulent flows in the spectral space. In this study, a preliminary attempt is pres... Closure models started from Chou's work have been developed for more than 70 years, aiming at providing analytical tools to describe turbulent flows in the spectral space. In this study, a preliminary attempt is presented to introduce a closure model in the physical space, using the velocity structure functions as key parameters. The present closure model appears to qualitatively reproduce the asymptotic scaling behav- iors at small and large scales, despite some inappropriate behaviors such as oscillations. Therefore, further improvements of the present model are expected to provide appropriate descriptions of turbulent flows in the physical space. 展开更多
关键词 homogeneous isotropic turbulence closure model structure function
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Non-equilibrium turbulent phenomena in transitional flat plate boundary-layer flows
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作者 Feng LIU le fang Jian fang 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2021年第4期567-582,共16页
Many recent laboratory experiments and numerical simulations support a non-equilibrium dissipation scaling in decaying turbulence before it reaches an equilibrium state.By analyzing a direct numerical simulation(DNS)d... Many recent laboratory experiments and numerical simulations support a non-equilibrium dissipation scaling in decaying turbulence before it reaches an equilibrium state.By analyzing a direct numerical simulation(DNS)database of a transitional boundary-layer flow,we show that the transition region and the non-equilibrium turbulence region,which are located in different streamwise zones,present different non-equilibrium scalings.Moreover,in the wall-normal direction,the viscous sublayer,log layer,and outer layer show different non-equilibrium phenomena which differ from those in grid-generated turbulence and transitional channel flows.These findings are expected to shed light on the modelling of various types of non-equilibrium turbulent flows. 展开更多
关键词 non-equilibrium turbulence flat plate boundary layer turbulence model
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Two-Dimensional Electron Gas in MoSi_(2)N_(4)/VSi_(2)N_(4)Heterojunction by First Principles Calculation
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作者 高瑞灵 刘超 +11 位作者 方乐 姚碧霞 吴伟 肖祁陵 胡顺波 刘禹 高恒 曹世勋 宋广生 孟祥建 陈效双 任伟 《Chinese Physics Letters》 SCIE EI CAS CSCD 2022年第12期57-64,共8页
Van der Waals(vdW)layered two-dimensional(2D)materials,which may have high carrier mobility,valley polarization,excellent mechanical properties and air stability,have been widely investigated before.We explore the pos... Van der Waals(vdW)layered two-dimensional(2D)materials,which may have high carrier mobility,valley polarization,excellent mechanical properties and air stability,have been widely investigated before.We explore the possibility of producing a spin-polarized two-dimensional electron gas(2DEG)in the heterojunction composed of insulators MoSi_(2)N_(4)and VSi_(2)N_(4)by using first-principles calculations.Due to the charge transfer effect,the 2DEG at the interface of the MoSi_(2)N_(4)/VSi_(2)N_(4)heterojunction is found.Further,for different kinds of stacking of heterojunctions,lattice strain and electric fields can effectively tune the electronic structures and lead to metal-to-semiconductor transition.Under compressive strain or electric field parallel to c axis,the 2DEG disappears and band gap opening occurs.On the contrary,interlayer electron transfer enforces the system to become metallic under the condition of tensile strain or electric field anti-parallel to c axis.These changes are mainly attributed to electronic redistribution and orbitals’reconstruction.In addition,we reveal that MoSi_(2)N_(4)/VSi_(2)N_(4)lateral heterojunctions of armchair and zigzag edges exhibit different electronic properties,such as a large band gap semiconductor and a metallic state.Our findings provide insights into electronic band engineering of MoSi_(2)N_(4)/VSi_(2)N_(4)heterojunctions and pave the way for future spintronics applications. 展开更多
关键词 HETEROJUNCTION POLARIZATION METALLIC
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The role of velocity derivative skewness in understanding non-equilibrium turbulence
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作者 刘锋 方乐 邵亮 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第11期99-105,共7页
The turbulence governed by the Navier-Stokes equation is paramount in many physical processes.However,it has been considered as a challenging problem due to its inherent nonlinearity,non-equilibrium,and complexity.Her... The turbulence governed by the Navier-Stokes equation is paramount in many physical processes.However,it has been considered as a challenging problem due to its inherent nonlinearity,non-equilibrium,and complexity.Herein,we review the connections between the velocity derivative skewness Sk and the non-equilibrium properties of turbulence.Sk,a reasonable candidate for describing the non-equilibrium turbulence,which varies during the non-equilibrium procedure.A lot of experimental or numerical evidences have shown that the perturbation of energy spectrum,which associated with the excitation of large scales,results in an obvious variation of Sk,and Sk is a negative value in this rapid energy decay process.The variation of positive Sk is closely related to the perturbation of transfer spectrum,and this corresponds to the backward energy transfer process.In addition,the skewness characterizes the production(or reduction)rate of enstrophy due to vortex stretching(or compression).Using the transport equation of turbulent energy dissipation rate and enstrophy,it is possible to establish a theoretical connection between skewness and the non-equilibrium turbulence.It is expected that this work could trigger the rapid advancement of the future studies of non-equilibrium turbulence,and also the improvement of turbulence models. 展开更多
关键词 velocity derivative skewness non-equilibrium turbulence turbulence model
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Correlation between large-and small-scale velocity components under Fourier filters
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作者 le fang 《Theoretical & Applied Mechanics Letters》 CAS 2014年第6期68-72,共5页
By introducing the Fourier filters, we analyse the correlation between large- and small-scale velocity components in homogeneous isotropic turbulence theoretically. We show that different Fourier filters act similarly... By introducing the Fourier filters, we analyse the correlation between large- and small-scale velocity components in homogeneous isotropic turbulence theoretically. We show that different Fourier filters act similarly on this multiscale correlation with a "natural" mechanism of removing the physical correlations between large- and small-scale velocity components. This conclusion calls for the further investigation on the Hilbert-Huang decomposition to investigate the mechanism of Marusic et al (2008). 展开更多
关键词 homogeneous isotropic turbulence large-eddy simulation correlation function fourier transform
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LRG47/EBP50重组慢病毒靶向载体疫苗增强RAW264.7小鼠巨噬细胞的抗结核免疫及机制 被引量:1
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作者 呙阳 周洁 +6 位作者 乐芳 王依珍 付鹏 苏日古 黄自坤 罗清 李俊明 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2022年第8期679-684,共6页
目的构建免疫相关p47 GTP酶/埃兹蛋白-根蛋白-膜突蛋白结合磷蛋白50(LRG47/EBP50)基因共表达重组慢病毒靶向载体,探讨该基因疫苗在抗结核免疫中的作用。方法利用分子克隆技术构建重组慢病毒质粒载体pLenti-EBP50-LRG47,包装成慢病毒LV-E... 目的构建免疫相关p47 GTP酶/埃兹蛋白-根蛋白-膜突蛋白结合磷蛋白50(LRG47/EBP50)基因共表达重组慢病毒靶向载体,探讨该基因疫苗在抗结核免疫中的作用。方法利用分子克隆技术构建重组慢病毒质粒载体pLenti-EBP50-LRG47,包装成慢病毒LV-EBP50-LRG47后,H37Rv菌株感染RAW264.7小鼠巨噬细胞。荷菌量计数检测各组杀菌能力,流式细胞术检测巨噬细胞的自噬和凋亡水平,Western blot法检测诱导型一氧化氮合酶(iNOS)蛋白表达,紫外分光光度计法检测一氧化氮(NO)的表达水平。结果重组慢病毒LV-EBP50-LRG47感染巨噬细胞后,可成功过表达EBP50和LRG47,与对照组相比,LV-EBP50-LRG47可显著抑制胞内H37Rv的生长,LV-EBP50-LRG47感染巨噬细胞自噬和凋亡水平显著上调,iNOS和NO表达水平显著上调。结论LRG47/EBP50共表达的巨噬细胞自噬、凋亡增强,iNOS、NO产生增加,显著抑制胞内H37Rv的生长。 展开更多
关键词 免疫相关p47 GTP酶(LRG47) 埃兹蛋白-根蛋白-膜突蛋白结合磷蛋白50(EBP50) 结核分枝杆菌(MTB) 巨噬细胞 自噬 凋亡 诱导型一氧化氮合酶(iNOS) 一氧化氮(NO)
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DTI and pathological changes in a rabbit model of radiation injury to the spinal cord after ^(125)I radioactive seed implantation 被引量:4
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作者 Xia Cao le fang +2 位作者 Chuan-yu Cui Shi Gao Tian-wei Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第3期528-535,共8页
Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological ch... Excessive radiation exposure may lead to edema of the spinal cord and deterioration of the nervous system. Magnetic resonance imaging can be used to judge and assess the extent of edema and to evaluate pathological changes and thus may be used for the evaluation of spinal cord injuries caused by radiation therapy. Radioactive ^125I seeds to irradiate 90% of the spinal cord tissue at doses of 40–100 Gy (D90) were implanted in rabbits at T10 to induce radiation injury, and we evaluated their safety for use in the spinal cord. Diffusion tensor imaging showed that with increased D90, the apparent diffusion coefficient and fractional anisotropy values were increased. Moreover, pathological damage of neurons and microvessels in the gray matter and white matter was aggravated. At 2 months after implantation, obvious pathological injury was visible in the spinal cords of each group. Magnetic resonance diffusion tensor imaging revealed the radiation injury to the spinal cord, and we quantified the degree of spinal cord injury through apparent diffusion coefficient and fractional anisotropy. 展开更多
关键词 nerve regeneration BRACHYTHERAPY ^125I radioactive seeds magnetic resonance imaging radiation injury of the spinal cord diffusion tensor imaging apparent diffusion coefficient fractional anisotropy neural regeneration
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Preparation of transparent BaSO_(4) nanodispersions by high-gravity reactive precipitation combined with surface modification for transparent X-ray shielding nanocomposite films 被引量:2
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作者 le fang Qian Sun +3 位作者 Yong-Hong Duan Jing Zhai Dan Wang Jie-Xin Wang 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2021年第4期902-912,共11页
BaSO_(4) nanoparticles as important functional materials have attracted considerable research interests,due to their X-rays barrier and absorption properties.However,most of BaSO_(4) nanoparticles prepared by traditio... BaSO_(4) nanoparticles as important functional materials have attracted considerable research interests,due to their X-rays barrier and absorption properties.However,most of BaSO_(4) nanoparticles prepared by traditional technology are nanopowders with broad size distribution and poor dispersibility,which may greatly limit their applications.To the best of our knowledge,the synthesis of transparent BaSO_(4) nanodispersions was rarely reported.Here,we firstly present a novel and efficient method to prepare transparent and stable BaSO_(4) nanodispersions with a relatively small particle size around 10 to 17 nm using a precipitation method in a rotating packed bed(RPB),followed by a modification treatment using stearic acid.Compared with the BaSO_(4) prepared in a traditional stirred tank,the product prepared using an RPB has much smaller particle size and narrower size distribution.More importantly,by using RPB,the reaction time can be significantly decreased from 20 min to 18 s.Furthermore,the transparent BaSO_(4)-polyvinyl butyral nanocomposite films with good X-ray shielding performance can be easily fabricated.We believe that the stable BaSO_(4) nanodispersions may have a wide range of applications for transparent composite materials and coatings with X-ray shielding performance for future research. 展开更多
关键词 BaSO_(4)nanoparticles rotating packed bed transparent nanodispersions BaSO_(4)-PVB films X-RAY
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Agronomic effectiveness of recovered phosphate fertilizer produced from incinerated sewage sludge ash
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作者 le fang Liping Li +2 位作者 Qiming Wang Jiang-shan Li Chi Sun Poon 《Waste Disposal and Sustainable Energy》 2022年第2期157-167,共11页
Phosphorus(P)recovery from incinerated sewage sludge ash(ISSA)has been extensively investigated,but insufficient research has been conducted to evaluate the effect of different kinds of recovered phosphate fertilizers... Phosphorus(P)recovery from incinerated sewage sludge ash(ISSA)has been extensively investigated,but insufficient research has been conducted to evaluate the effect of different kinds of recovered phosphate fertilizers(RPFs)on plant growth with respect to the P and heavy metal contents of RPFs.In this study,three kinds of RPFs,precipitated calcium phosphate fertilizer(CaP),struvite phosphate fertilizer(SP),and P-loaded biochar(BP),produced from ISSA were characterized,and their agronomic effectiveness was verified by hydroponic and soil cultivation.In addition to the three kinds of RPFs,a control group(mono-phosphate fertilizer in hydroponic group/compound fertilizer in soil cultivation group)and a blank control group(BC,with zero P)were tested on choy sum and ryegrass at the same time.SP has the highest P purity(76.0%of struvite)while the BP has the most complex P species(P was co-exist with Fe,Al,and Mg).Plant growth results showed that the RPFs greatly facilitated plant growth and demonstrated superior/comparable effects to those of control group.In hydroponics testing,SP showed the best effect(shoot length of 17.0 cm,chlorophyll content of 2.05 mg/g)due to the Mg involved and the high P purity of SP,while BP performed the best(shoot length of 13.7 cm,chlorophyll content of 2.42 mg/g)in the soil testing system among all of the groups because of the additional nutritional elements and the high P availability of BP.Additionally,the accumulation of heavy metals in the plants under all conditions did not exceed the limits stipulated in the regulations.These results indicate that recovering P from ISSA is an attractive technology to produce P fertilizers,which can alleviate both the scarcity of phosphate resources and the burden of ISSA management. 展开更多
关键词 Recovered phosphate fertilizer Incinerated sewage sludge ash Agronomic analysis Heavy metals Waste management
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Correction to:Agronomic effectiveness of recovered phosphate fertilizer produced from incinerated sewage sludge ash
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作者 le fang Liping Li +2 位作者 Qiming Wang Jiang-shan Li Chi Sun Poon 《Waste Disposal and Sustainable Energy》 2022年第3期257-258,共2页
In this article,the affiliation details for Author Chi Sun Poon were incorrectly given as'State Key Laboratory of Water Environment Simulation,School of Environment,Beijing Normal University,Beijing 100875,China&#... In this article,the affiliation details for Author Chi Sun Poon were incorrectly given as'State Key Laboratory of Water Environment Simulation,School of Environment,Beijing Normal University,Beijing 100875,China'and'State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences,Wuhan 430071,China'but should have been'Department of Civil and Environmental Engineering,The Hong Kong Polytechnic University,Kowloon,Hong Kong,China'and'IRSM-CAS/HK PolyU Joint Laboratory on Solid Waste Science,Kowloon,Hong Kong,China'.The original article has been corrected. 展开更多
关键词 DETAILS SEWAGE SLUDGE
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