Clinical Study on Treatment to Ankylosing Spondylitis with Fengshi Qutong Capsule-Diclofenac Sodium Combination

Objective:To discuss the clinical study on Fengshi Qutong capsules combined with diclofenac sodium in the treatment of ankylosing spondylitis.Methods:80 patients who were treated for ankylosing spondylitis from June 2019 to June 2020 were selected and divided into two groups.The experimental group was treated with Fengshi Qutong capsules combined with diclofenac sodium,and the control group was treated with sulfasalazine enteric-coated tablets.Results:The treatment efficacy,VAS score,BASDAI score,BASFI score,CRP level,TNF-α level,IL-Iβ level,and the incidence of adverse reactions between the two groups were significantly different(P<0.05).Conclusion:The application of Fengshi Qutong capsules combined with diclofenac sodium in the treatment of patients with ankylosing spondylitis is beneficial to improve the treatment efficacy,reduce the levels of CRP,TNF-α,and IL-Iβ,reduce the incidence of adverse reactions,and reduce the VAS,BASDAI and BASFI scores,rendering it of important clinical value.

Hot deformation behavior and microstructure evolution of a Mg–Gd–Nd–Y–Zn alloy

The hot deformation behavior of homogenized Mg-6.5Gd-l.3Nd4）.7Y-0.3Zn alloy was investigated during compression at temperatures of 250-400 ℃ and at strain rates ranging from 0.001 to 0.100 s- 1. Microstructure analyses show that the flow behaviors are associated with the deformation mechanisms. At the lower temperatures （250-300 ℃）, defor- mation twinning is triggered due to the difficult activation of dislocation cross-slip. Dynamic recrystallization （DRX） ac- companied by dynamic precipitation occurs at the temperature of 350 ℃ and influences the softening behavior of the flow. DRX that develops extensively at original grain boundaries is the main softening mechanism at the high temperature of 400 ℃ and eventually brings a more homogeneous mi- crostructure than that in other deformation conditions. The volume fraction of the DRXed grains increases with tem- perature increasing and decreases with strain rate increasing.

Same impact momentum causes different degrees of spinal cord injury

The weight-drop impact is widely used in making animal model of spinal cord injury(SCI).But there has not yet been an appropriate unit for the quantification of the impact.In this study,we compared the degrees of the spinal cord injury caused by weight-drop impact with the same momentum but different combinations of drop weight and drop height,in order to test whether‘‘momentum’’is capable of being the unit for the quantification of weightdrop impact.Thirty adult rats were randomly allocated to three groups and were injured with 5 g–10 cm(group A),10 g–2.5 cm(group B)and 15 g–1.11 cm(group C)impacts with the same momentum to the spinal cord,respectively.Open-field locomotor function was evaluated using the Basso–Beattie–Bresnahan(BBB)locomotor rating scale.The percentage of spared tissue area(STA)at the epicenter,and 500,1000 and 1500 lm from the epicenter was calculated using serial sections stained by hematoxylin and eosin.As a result,the behavioral recovery(BBB scores)and the STA percentage were similar in group B and group C.However,the BBB score in group A was significantly lower than that in groups B and C at the same time point post injury.The STA percentage was significantly less and the lesion/cavity length was significantlygreater in group A than in groups B and C.These suggested that the 5 g–10 cm weight-drop impact,compared with the other two impacts with different weights and heights,caused a greater damage of the spinal cord when the momentum was the same.So,these impacts with the same momentum but different weights and drop heights cause different degrees of spinal cord injury.Momentum alone is inadequate to be the unit for the qualification of weightdrop impact and to be used to predict the extent of injury.