目的探讨患者健康问卷躯体症状群量表-15(Patient health questionnaire,PHQ-15)、广泛性焦虑量表-7(Generalized anxiety disorder,GAD-7)、抑郁症状群量表-9(Patient health questionnaire,PHQ-9)与匹兹堡睡眠质量指数量表(Pittsburgh...目的探讨患者健康问卷躯体症状群量表-15(Patient health questionnaire,PHQ-15)、广泛性焦虑量表-7(Generalized anxiety disorder,GAD-7)、抑郁症状群量表-9(Patient health questionnaire,PHQ-9)与匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)在评估门诊女性不孕症患者身心健康方面的应用价值。方法选取2020年6~10月在我院门诊就诊的1823例女性不孕症患者为研究对象,采用PHQ-15、GAD-7、PHQ-9、PSQI量表以问卷形式开展调查,问卷内容包括患者的一般情况、躯体症状、焦虑情绪、抑郁症状及睡眠质量等身心健康状况。分别采用克朗巴哈系数(Cronbach’sα)和Spearman-Brown折半系数分析评估4个量表的信度,采用因子分析KMO值评估4个量表的效度;将4个量表进行两两配对,采用Spearman相关性分析其相关性;采用单因素和多因素Logistic回归分析,分析导致患者产生焦虑和抑郁症状的潜在危险因素。结果本研究一共向1882例门诊就诊的不孕症患者发放问卷调查,共回收有效问卷1823张,问卷回收率为96.9%。所有纳入的患者中1108例为无躯体症状患者、1349例为无焦虑症状患者、1238例为无抑郁症状患者、975例为睡眠质量较好的患者;PHQ-15、GAD-7、PHQ-9与PSQI量表的Cronbach’sα系数依次为0.809、0.870、0.825和0.758,Spearman-Brown折半系数依次为0.700、0.852、0.793和0.783,KMO值依次为0.892、0.890、0.913和0.862;Spearman相关性分析显示,4个量表之间相关性较好(r>0.5且P<0.05)。单因素及多因素Logistic回归分析发现,大专及以上学历、轻度/中度/重度躯体症状、睡眠质量一般/较差是导致患者产生焦虑症状的独立危险因素(P<0.05);而年龄>35岁、轻度/中度/重度躯体症状、睡眠质量一般/较差是导致患者产生抑郁症状的独立危险因素(P<0.05)。结论PHQ-15、GAD-7、PHQ-9和PSQI量表在评估门诊不孕症患者身心健康方面有较好的运用。躯体症状和睡眠障碍均会显著增加患者伴发焦虑症状和抑郁症状的风险,同时高学历患者更容易合并焦虑症状,而高龄患者则更易合并抑郁症状,因此门诊应当加强对高龄和高学历层次患者身心健康状态的筛查力度,做到早期发现,精准干预,精准治疗。展开更多
目的探讨血清糖类抗原125(CA125)、人附睾蛋白4(HE4)及骨桥蛋白(OPN)联合检测在卵巢癌中的诊断意义。方法收集2016年8月至2017年5月本院经病理确诊的卵巢良性囊肿患者血清58例,卵巢癌患者血清66例(按照FIGO临床分期标准,其中Ⅰ期17例,Ⅱ...目的探讨血清糖类抗原125(CA125)、人附睾蛋白4(HE4)及骨桥蛋白(OPN)联合检测在卵巢癌中的诊断意义。方法收集2016年8月至2017年5月本院经病理确诊的卵巢良性囊肿患者血清58例,卵巢癌患者血清66例(按照FIGO临床分期标准,其中Ⅰ期17例,Ⅱ期21例,Ⅲ期13例,Ⅳ期15例)作为观察组,同时收集健康体检妇女(经B超检查排除卵巢及其它妇科疾病)的血清样本60例作为正常对照组。分别利用化学发光法检测各组中的血清CA125含量,酶联免疫法检测HE4及OPN含量,通过受试者工作曲线(receiver operator characteristic,ROC)计算曲线下面积(area under the curve,AUC)及各指标的灵敏度和特异性,评价标志物单独及联合检测对卵巢癌的诊断意义。结果与正常对照组相比,CA125、HE4及OPN在卵巢癌中均有明显的升高,差异有统计学意义(P<0.05)。在卵巢癌组中的Ⅱ、Ⅲ、Ⅳ期,其CA125、HE4及OPN的含量较卵巢囊肿组升高,有统计学差异。CA125、HE4、OPN及CA125+HE4+OPN在诊断卵巢癌时,其ROC曲线下AUC分别为0.74、0.89、0.81和0.95;各指标的诊断灵敏度分别为48.2%、76.8%、71.7%及94.5%;特异性为72.7%、87.4%、79.8%及92.6%。结论卵巢癌患者的血清CA125、HE4及OPN含量明显高于卵巢囊肿患者(除卵巢癌Ⅰ期)及正常人群;相对于单一项目检测,血清CA125、HE4及OPN三者联合检测能大大提高卵巢癌诊断的特异性(除HE4)和灵敏度,为患者的早期诊断提供帮助。展开更多
This paper reviews the rescue experience of our medical rescue team during the relief of Wenchuan earthquake in 2008 in Sichuan province, China, and analyzes the psychological reaction of team members. Based on the re...This paper reviews the rescue experience of our medical rescue team during the relief of Wenchuan earthquake in 2008 in Sichuan province, China, and analyzes the psychological reaction of team members. Based on the rescuers' distinctive psychological reaction in different phases of the rescue operation, we aims to propose measures for administration of the team in order to better fulfill the rescue duties and provide references for future medical service in non-war operations such as an earthquake relief.展开更多
Biomass-derived 2,5-bis(hydroxymethyl)furan(BHMF)has received great attention and interest due to its broad application prospects in polyesters and medicine.Over the past decades,the catalytic systems including thermo...Biomass-derived 2,5-bis(hydroxymethyl)furan(BHMF)has received great attention and interest due to its broad application prospects in polyesters and medicine.Over the past decades,the catalytic systems including thermocatalytic,biocatalytic,electrocatalytic,and photocatalytic hydrogenation of 5-hydroxymethylfurfural(HMF)into BHMF have been developed to a great extent.To understand the present status and challenges of BHMF production,this review systematically evaluates recent findings and developments of HMF hydrogenation through various reaction systems,with an emphasis on catalyst screening,synthesis processes,and reaction mechanism.Furthermore,a few potential research trends are also proposed,in order to provide innovative ideas for further exploration of BHMF synthesis in a simpler,efficient,and economical way.展开更多
文摘目的探讨患者健康问卷躯体症状群量表-15(Patient health questionnaire,PHQ-15)、广泛性焦虑量表-7(Generalized anxiety disorder,GAD-7)、抑郁症状群量表-9(Patient health questionnaire,PHQ-9)与匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)在评估门诊女性不孕症患者身心健康方面的应用价值。方法选取2020年6~10月在我院门诊就诊的1823例女性不孕症患者为研究对象,采用PHQ-15、GAD-7、PHQ-9、PSQI量表以问卷形式开展调查,问卷内容包括患者的一般情况、躯体症状、焦虑情绪、抑郁症状及睡眠质量等身心健康状况。分别采用克朗巴哈系数(Cronbach’sα)和Spearman-Brown折半系数分析评估4个量表的信度,采用因子分析KMO值评估4个量表的效度;将4个量表进行两两配对,采用Spearman相关性分析其相关性;采用单因素和多因素Logistic回归分析,分析导致患者产生焦虑和抑郁症状的潜在危险因素。结果本研究一共向1882例门诊就诊的不孕症患者发放问卷调查,共回收有效问卷1823张,问卷回收率为96.9%。所有纳入的患者中1108例为无躯体症状患者、1349例为无焦虑症状患者、1238例为无抑郁症状患者、975例为睡眠质量较好的患者;PHQ-15、GAD-7、PHQ-9与PSQI量表的Cronbach’sα系数依次为0.809、0.870、0.825和0.758,Spearman-Brown折半系数依次为0.700、0.852、0.793和0.783,KMO值依次为0.892、0.890、0.913和0.862;Spearman相关性分析显示,4个量表之间相关性较好(r>0.5且P<0.05)。单因素及多因素Logistic回归分析发现,大专及以上学历、轻度/中度/重度躯体症状、睡眠质量一般/较差是导致患者产生焦虑症状的独立危险因素(P<0.05);而年龄>35岁、轻度/中度/重度躯体症状、睡眠质量一般/较差是导致患者产生抑郁症状的独立危险因素(P<0.05)。结论PHQ-15、GAD-7、PHQ-9和PSQI量表在评估门诊不孕症患者身心健康方面有较好的运用。躯体症状和睡眠障碍均会显著增加患者伴发焦虑症状和抑郁症状的风险,同时高学历患者更容易合并焦虑症状,而高龄患者则更易合并抑郁症状,因此门诊应当加强对高龄和高学历层次患者身心健康状态的筛查力度,做到早期发现,精准干预,精准治疗。
文摘目的探讨血清糖类抗原125(CA125)、人附睾蛋白4(HE4)及骨桥蛋白(OPN)联合检测在卵巢癌中的诊断意义。方法收集2016年8月至2017年5月本院经病理确诊的卵巢良性囊肿患者血清58例,卵巢癌患者血清66例(按照FIGO临床分期标准,其中Ⅰ期17例,Ⅱ期21例,Ⅲ期13例,Ⅳ期15例)作为观察组,同时收集健康体检妇女(经B超检查排除卵巢及其它妇科疾病)的血清样本60例作为正常对照组。分别利用化学发光法检测各组中的血清CA125含量,酶联免疫法检测HE4及OPN含量,通过受试者工作曲线(receiver operator characteristic,ROC)计算曲线下面积(area under the curve,AUC)及各指标的灵敏度和特异性,评价标志物单独及联合检测对卵巢癌的诊断意义。结果与正常对照组相比,CA125、HE4及OPN在卵巢癌中均有明显的升高,差异有统计学意义(P<0.05)。在卵巢癌组中的Ⅱ、Ⅲ、Ⅳ期,其CA125、HE4及OPN的含量较卵巢囊肿组升高,有统计学差异。CA125、HE4、OPN及CA125+HE4+OPN在诊断卵巢癌时,其ROC曲线下AUC分别为0.74、0.89、0.81和0.95;各指标的诊断灵敏度分别为48.2%、76.8%、71.7%及94.5%;特异性为72.7%、87.4%、79.8%及92.6%。结论卵巢癌患者的血清CA125、HE4及OPN含量明显高于卵巢囊肿患者(除卵巢癌Ⅰ期)及正常人群;相对于单一项目检测,血清CA125、HE4及OPN三者联合检测能大大提高卵巢癌诊断的特异性(除HE4)和灵敏度,为患者的早期诊断提供帮助。
文摘This paper reviews the rescue experience of our medical rescue team during the relief of Wenchuan earthquake in 2008 in Sichuan province, China, and analyzes the psychological reaction of team members. Based on the rescuers' distinctive psychological reaction in different phases of the rescue operation, we aims to propose measures for administration of the team in order to better fulfill the rescue duties and provide references for future medical service in non-war operations such as an earthquake relief.
基金the financial support of the National Natural Science Foundation of China(22278121,21975070)Hunan Provincial Innovation Foundation for Postgraduate(QL20210132)the funding offered by China Scholarship Council(202106720021).
文摘Biomass-derived 2,5-bis(hydroxymethyl)furan(BHMF)has received great attention and interest due to its broad application prospects in polyesters and medicine.Over the past decades,the catalytic systems including thermocatalytic,biocatalytic,electrocatalytic,and photocatalytic hydrogenation of 5-hydroxymethylfurfural(HMF)into BHMF have been developed to a great extent.To understand the present status and challenges of BHMF production,this review systematically evaluates recent findings and developments of HMF hydrogenation through various reaction systems,with an emphasis on catalyst screening,synthesis processes,and reaction mechanism.Furthermore,a few potential research trends are also proposed,in order to provide innovative ideas for further exploration of BHMF synthesis in a simpler,efficient,and economical way.
