Aims: To investigate the effect on risk of major adverse cardiac events(MACE) of lipid lowering treatment with fluvastatin 80 mg/day after a first percutaneous coronary intervention in patientswith stable and unstable...Aims: To investigate the effect on risk of major adverse cardiac events(MACE) of lipid lowering treatment with fluvastatin 80 mg/day after a first percutaneous coronary intervention in patientswith stable and unstable angina. Method and results: This prespecified subgroup analysis of the LIPS(Lescol intervention prevention study) analysed 1658 patients with documented diagnosis; 824 had unstable angina(417 randomly assigned to fluvastatin, 407 to placebo) and 834 had stable angina(including silent ischaemia; fluvastatin, 418; placebo, 416). Median follow up was 3.9 years. There was no significant effect of anginal status on long term risk of MACE. Fluvastatin treatment reduced the risk ofMACE by 28%compared with placebo (p=0.03) among patients with unstable angina, with no difference between patients with stable and patients with unstable angina(relative risk 1.07, 95%confidence interval 0.87 to 1.30, p=0.53). Fluvastatin reduced coronary atherosclerotic events (MACE excluding restenosis) by 36%(p=0.006) among patients with unstable angina and 31%(p=0.02) among patients with stable angina. Fluvastatin caused similar reductions in total cholesterol and low density lipoprotein cholesterol concentrations in both patient groups. Conclusion: Treatment with fluvastatin 80 mg/day produced significant reductions inMACE and coronary atherosclerotic events after percutaneous coronary intervention in patientswith average cholesterol concentrations. The beneficial effects of fluvastatin are observed in patients with unstable or stable angina alike.展开更多
Congenital Langerhans cell histiocytosis (LCH) encompasses a wide spectrum of disease involvement and severity. Congenital “self-healing”cutaneous LCH represents one end of the spectrum, whereas the case we encounte...Congenital Langerhans cell histiocytosis (LCH) encompasses a wide spectrum of disease involvement and severity. Congenital “self-healing”cutaneous LCH represents one end of the spectrum, whereas the case we encountered represents the other extreme. A rare case of congenital LCH with severe multiorgan involvement presenting as hydrops fetalis is described in this report. Hydrops fetalis has not previously been associated with congenital LCH. The overall clinical features of this infant closely mimicked those of disseminated congenital infection, and he ran a fulminant and rapidly fatal course. Conclusion: A high index of suspicion is required to diagnose congenital LCH in the early neonatal period. Hydrops fetalis is an ominous sign and probably reflects severe systemic disease compromising the well-being of the fetus.展开更多
This study aimed to investigate 1) the plasma resistin concentration at birth, 2) the relationship of resistin with leptin and insulin, and 3) the association of resistin with anthropometric indexes in newborn infants...This study aimed to investigate 1) the plasma resistin concentration at birth, 2) the relationship of resistin with leptin and insulin, and 3) the association of resistin with anthropometric indexes in newborn infants. Blood samples for hormonal assay were obtained from preterm and term newborns within the first 2 h of life and before milk feeding or energy intake. Although these infants required blood sampling for clinical reasons, all were proved to be noninfected. Plasma resistin was significantly higher in term than in preterm infants. It was also significantly correlated with serum leptin, and both hormones were significantly associated with gestational age and anthropometric indexes. Infants who were born vaginally were found to have significantly higher plasma resistin levels compared with those who were born by cesarean section. In the multivariate forward stepwise regression models, resistin was found to be significantly associated with the mode of delivery and gestational age or birth weight. The association among resistin, leptin, and anthropometric indexes suggested that both hormones might be gestation related. A high circulating resistin level at term gestation could be advantageous to the infant by promoting hepatic glucose production and preventing hypoglycemia after birth. Infants who were born vaginally had significantly higher plasma resistin levels, suggesting that this hormone might also be associated with stress or inflammation induced by the birth process.展开更多
文摘Aims: To investigate the effect on risk of major adverse cardiac events(MACE) of lipid lowering treatment with fluvastatin 80 mg/day after a first percutaneous coronary intervention in patientswith stable and unstable angina. Method and results: This prespecified subgroup analysis of the LIPS(Lescol intervention prevention study) analysed 1658 patients with documented diagnosis; 824 had unstable angina(417 randomly assigned to fluvastatin, 407 to placebo) and 834 had stable angina(including silent ischaemia; fluvastatin, 418; placebo, 416). Median follow up was 3.9 years. There was no significant effect of anginal status on long term risk of MACE. Fluvastatin treatment reduced the risk ofMACE by 28%compared with placebo (p=0.03) among patients with unstable angina, with no difference between patients with stable and patients with unstable angina(relative risk 1.07, 95%confidence interval 0.87 to 1.30, p=0.53). Fluvastatin reduced coronary atherosclerotic events (MACE excluding restenosis) by 36%(p=0.006) among patients with unstable angina and 31%(p=0.02) among patients with stable angina. Fluvastatin caused similar reductions in total cholesterol and low density lipoprotein cholesterol concentrations in both patient groups. Conclusion: Treatment with fluvastatin 80 mg/day produced significant reductions inMACE and coronary atherosclerotic events after percutaneous coronary intervention in patientswith average cholesterol concentrations. The beneficial effects of fluvastatin are observed in patients with unstable or stable angina alike.
文摘Congenital Langerhans cell histiocytosis (LCH) encompasses a wide spectrum of disease involvement and severity. Congenital “self-healing”cutaneous LCH represents one end of the spectrum, whereas the case we encountered represents the other extreme. A rare case of congenital LCH with severe multiorgan involvement presenting as hydrops fetalis is described in this report. Hydrops fetalis has not previously been associated with congenital LCH. The overall clinical features of this infant closely mimicked those of disseminated congenital infection, and he ran a fulminant and rapidly fatal course. Conclusion: A high index of suspicion is required to diagnose congenital LCH in the early neonatal period. Hydrops fetalis is an ominous sign and probably reflects severe systemic disease compromising the well-being of the fetus.
文摘This study aimed to investigate 1) the plasma resistin concentration at birth, 2) the relationship of resistin with leptin and insulin, and 3) the association of resistin with anthropometric indexes in newborn infants. Blood samples for hormonal assay were obtained from preterm and term newborns within the first 2 h of life and before milk feeding or energy intake. Although these infants required blood sampling for clinical reasons, all were proved to be noninfected. Plasma resistin was significantly higher in term than in preterm infants. It was also significantly correlated with serum leptin, and both hormones were significantly associated with gestational age and anthropometric indexes. Infants who were born vaginally were found to have significantly higher plasma resistin levels compared with those who were born by cesarean section. In the multivariate forward stepwise regression models, resistin was found to be significantly associated with the mode of delivery and gestational age or birth weight. The association among resistin, leptin, and anthropometric indexes suggested that both hormones might be gestation related. A high circulating resistin level at term gestation could be advantageous to the infant by promoting hepatic glucose production and preventing hypoglycemia after birth. Infants who were born vaginally had significantly higher plasma resistin levels, suggesting that this hormone might also be associated with stress or inflammation induced by the birth process.
