Y-chromosome microdeletion in male fetuses conceived by intracytoplasmic sperm injection (ICSI) was screened by polymerase chain reaction for sequence-tagged sites in azoospermia factor (AZF)-b and AZFc regions. Treat...Y-chromosome microdeletion in male fetuses conceived by intracytoplasmic sperm injection (ICSI) was screened by polymerase chain reaction for sequence-tagged sites in azoospermia factor (AZF)-b and AZFc regions. Treatment with ICSI may lead to vertical transmission, expansion, and de novo Y-chromosome microdeletion in male fetuses.展开更多
Objective: Polyneuropathy, organomegaly, endocrinopathy,M protein, and skin ch anges (POEMS) syndrome is a rare cause of polyneuropathy. Although the polyneuro pathy component is essential for the diagnosis of the dis...Objective: Polyneuropathy, organomegaly, endocrinopathy,M protein, and skin ch anges (POEMS) syndrome is a rare cause of polyneuropathy. Although the polyneuro pathy component is essential for the diagnosis of the disease, the pattern of as sociated electrodiagnostic abnormalities has not been characterized in detail. T he purpose of this study was to elucidate the features of nerve conduction abnor malities in POEMS syndrome.Methods: We reviewed the medical records and nerve co nduction studies(NCS) of 12 consecutive patients with POEMS.Results: A total of 68 motor and 46 sensory nerves were examined.Compound muscle action potentials(C MAPs) and sensory nerve action potentials(SNAPs) were not elicited in lower limb s more frequently compared with in upper limbs (P < 0.05, in both motor and sens ory nerves), and the CMAP amplitude was more attenuated in lower limbs than in u pper limbs (P < 0.05). Abnormal conduction slowing was frequently observed in mo tor (95%) and sensory (76%) nerves. Distal motor latencies were abnormally pro longed in 75%of the motor nerves,and terminal latency indices were significant - ly higher in patients than in normal controls (P < 0.05). Conclusions: NCS in POEMS syndrome showed characteristic patterns, in which conduction abnormalities were more frequently and severely affected in the lower limbs, and more predomi nantly in the intermediate nerve segments than in the distal portions. Significa nce:The recognition of these characteristic patterns may be helpful for the earl y diagnosis of polyneuropathy in POEMS syndrome.展开更多
文摘Y-chromosome microdeletion in male fetuses conceived by intracytoplasmic sperm injection (ICSI) was screened by polymerase chain reaction for sequence-tagged sites in azoospermia factor (AZF)-b and AZFc regions. Treatment with ICSI may lead to vertical transmission, expansion, and de novo Y-chromosome microdeletion in male fetuses.
文摘Objective: Polyneuropathy, organomegaly, endocrinopathy,M protein, and skin ch anges (POEMS) syndrome is a rare cause of polyneuropathy. Although the polyneuro pathy component is essential for the diagnosis of the disease, the pattern of as sociated electrodiagnostic abnormalities has not been characterized in detail. T he purpose of this study was to elucidate the features of nerve conduction abnor malities in POEMS syndrome.Methods: We reviewed the medical records and nerve co nduction studies(NCS) of 12 consecutive patients with POEMS.Results: A total of 68 motor and 46 sensory nerves were examined.Compound muscle action potentials(C MAPs) and sensory nerve action potentials(SNAPs) were not elicited in lower limb s more frequently compared with in upper limbs (P < 0.05, in both motor and sens ory nerves), and the CMAP amplitude was more attenuated in lower limbs than in u pper limbs (P < 0.05). Abnormal conduction slowing was frequently observed in mo tor (95%) and sensory (76%) nerves. Distal motor latencies were abnormally pro longed in 75%of the motor nerves,and terminal latency indices were significant - ly higher in patients than in normal controls (P < 0.05). Conclusions: NCS in POEMS syndrome showed characteristic patterns, in which conduction abnormalities were more frequently and severely affected in the lower limbs, and more predomi nantly in the intermediate nerve segments than in the distal portions. Significa nce:The recognition of these characteristic patterns may be helpful for the earl y diagnosis of polyneuropathy in POEMS syndrome.
