Objective. Functional dyspepsia (FD) is a heterogeneous and loosely defined clinical syndrome that is characterized by persistent or recurrent abdominal pain or discomfort centered in the upper abdomen without any ide...Objective. Functional dyspepsia (FD) is a heterogeneous and loosely defined clinical syndrome that is characterized by persistent or recurrent abdominal pain or discomfort centered in the upper abdomen without any identifiable structural or biochemical basis. Gastric myoelectrical activity in functional dyspepsia patients with gastric reddish streaks as a subgroup has not previously been investigated and the potential role of psychosocial distress in the genesis of gastric dysrhythmia in patients with FD is unclear. Material and methods. Electrogastrography was performed in 45 patients with FD and 35 healthy controls for 30 min in the fasting state and 30 min postprandially. Psychological distress and the number and severity of stressful life events were measured using self-rating questionnaires. Results. FD patients had a higher percentage of pre-and postprandial dysrhythmia, lower dominant frequency, and a higher instability coefficient as compared to healthy controls. In FD patients, severity of stressful life events was positively correlated with the percentage of tachygastria in the fasting state ( r=0.43, p=0.005) and marginally positively co-rrelated with the percentage of postprandial tachygastria ( r =0.253, p =0.098) and instability coefficient of the dominant frequency ( r =0.256, p =0.093). Total nu-mber of stressful life events was marginally positively correlated with fasting tachygastria ( r =0.25, p =0.098) and instability coefficient of the postprandial dominant frequency ( r =0.287, p =0.056). Interpersonal sensitivity was found to be negatively correlated with fasting dominant frequency in FD patients (r = -0.311, p < 0.05). Conclusions. FD patients with gastric reddish streaks have abnormal fasting and postprandial gastric myoelectrical activity. Perceived severity of stressful life events and interpersonal sensitivity are associated with disturbance of gastric myoelectrical activity.展开更多
Background: Myelin protein zero gene (MPZ) mutations may account for a small p roportion of cases of Charcot-Marie-Tooth disease (CMT). Different MPZ mutatio ns may be associated with different clinical and electrophy...Background: Myelin protein zero gene (MPZ) mutations may account for a small p roportion of cases of Charcot-Marie-Tooth disease (CMT). Different MPZ mutatio ns may be associated with different clinical and electrophysiological phenotypes .Objectives: To expand our understanding of the characteristics of nerve conduct ion velocity (NCV) in patients with different MPZ mutations, the authors collect ed and analysed the NCVvalues from patients with MPZ mutations. Materials and Me thods:The NCVs of fourteen patients from six families carrying MPZ mutations of Val58Asp, Ser63Phe, Thr65Ile,Arg98Cys,Arg98His, and Ser233fs were collected retr ospectively. Five of them had received nerve conduction studies (NCS) twice. The mutations were verified by polymerase chain reaction (PCR)-amplifications and nucleotide sequencing. Scatterplot analyses of media n motor NCV (MNCV) versus specific MPZ mutation were performed. Results: The med ian MNCV varied widely,with a mean of 16.3 m/s (SD=7.7 m/s) and a range of 5.1- 32.9 m/s. Median MNCVs of patients with particular MPZ mutations were similar. M oreover, Median MNCV did not change significantly over time. Conclusions: There was concordance between median MNCV and specific MPZ mutations.However, median M NCV is not an ideal measure with which to distinguish CMT1B patients with MPZ mu tations from CMT1A patients with PMP22 mutations.展开更多
To describe the adverse effect of abdominal cramp caused by travoprost ophthalmic solution in a glaucoma patient. Case report. A 34- year-old woman reported abdominal cramp on topical application of travoprost ophthal...To describe the adverse effect of abdominal cramp caused by travoprost ophthalmic solution in a glaucoma patient. Case report. A 34- year-old woman reported abdominal cramp on topical application of travoprost ophthalmic solution. Satisfactory dechallenge and rechallenge procedures were performed. Abdominal cramp occurred approximately 30 minutes after topical application of travoprost on 3 consecutive days. No abdominal cramp developed after substitution of travoprost with latanoprost or normal saline (in the Travatan bottle). Abdominal cramps recurred on rechallenging with travoprost, either in the original Travatan bottle, a latanoprost bottle, or in a Rescula bottle. Flu-like symptoms (abdominal cramps, malaise and URI) were reported in 4% of patients participating in clinical trials of travoprost but seldom reported postmarketing. Based on the findings of dechallenge and rechallenge procedures, abdominal cramp should be considered a certain adverse effect of travoprost according to the WHO classification.展开更多
Recurrence of endometrial cancer in the brain is a rare event generally accompanied by limi ted life expectancy.We present an unusual case of long -te rm survival follow-ing surgical resection of an intracranial endom...Recurrence of endometrial cancer in the brain is a rare event generally accompanied by limi ted life expectancy.We present an unusual case of long -te rm survival follow-ing surgical resection of an intracranial endometrial cancer metastasis.The present case is a patient with FIGO stage IIB,grade III endometrial cancer which recurred 2months following completion of primary therapy with an isolated lesion in the brain.Aggressive trim odal therapy was initi-ated with curative intent and she has remained without clinical or radiographic evidence o f disease for more than30months following treatment of her recurrence.Aggres-sive multi -modal therapy is warrant ed in the treatment of isolated intracranial recurrences of endometrial cancer in carefully selected patients.With c omplete surgical resec-tion of disease,the precise nature a nd role of adjuvant treatment has yet to be clearly defin ed.展开更多
文摘Objective. Functional dyspepsia (FD) is a heterogeneous and loosely defined clinical syndrome that is characterized by persistent or recurrent abdominal pain or discomfort centered in the upper abdomen without any identifiable structural or biochemical basis. Gastric myoelectrical activity in functional dyspepsia patients with gastric reddish streaks as a subgroup has not previously been investigated and the potential role of psychosocial distress in the genesis of gastric dysrhythmia in patients with FD is unclear. Material and methods. Electrogastrography was performed in 45 patients with FD and 35 healthy controls for 30 min in the fasting state and 30 min postprandially. Psychological distress and the number and severity of stressful life events were measured using self-rating questionnaires. Results. FD patients had a higher percentage of pre-and postprandial dysrhythmia, lower dominant frequency, and a higher instability coefficient as compared to healthy controls. In FD patients, severity of stressful life events was positively correlated with the percentage of tachygastria in the fasting state ( r=0.43, p=0.005) and marginally positively co-rrelated with the percentage of postprandial tachygastria ( r =0.253, p =0.098) and instability coefficient of the dominant frequency ( r =0.256, p =0.093). Total nu-mber of stressful life events was marginally positively correlated with fasting tachygastria ( r =0.25, p =0.098) and instability coefficient of the postprandial dominant frequency ( r =0.287, p =0.056). Interpersonal sensitivity was found to be negatively correlated with fasting dominant frequency in FD patients (r = -0.311, p < 0.05). Conclusions. FD patients with gastric reddish streaks have abnormal fasting and postprandial gastric myoelectrical activity. Perceived severity of stressful life events and interpersonal sensitivity are associated with disturbance of gastric myoelectrical activity.
文摘Background: Myelin protein zero gene (MPZ) mutations may account for a small p roportion of cases of Charcot-Marie-Tooth disease (CMT). Different MPZ mutatio ns may be associated with different clinical and electrophysiological phenotypes .Objectives: To expand our understanding of the characteristics of nerve conduct ion velocity (NCV) in patients with different MPZ mutations, the authors collect ed and analysed the NCVvalues from patients with MPZ mutations. Materials and Me thods:The NCVs of fourteen patients from six families carrying MPZ mutations of Val58Asp, Ser63Phe, Thr65Ile,Arg98Cys,Arg98His, and Ser233fs were collected retr ospectively. Five of them had received nerve conduction studies (NCS) twice. The mutations were verified by polymerase chain reaction (PCR)-amplifications and nucleotide sequencing. Scatterplot analyses of media n motor NCV (MNCV) versus specific MPZ mutation were performed. Results: The med ian MNCV varied widely,with a mean of 16.3 m/s (SD=7.7 m/s) and a range of 5.1- 32.9 m/s. Median MNCVs of patients with particular MPZ mutations were similar. M oreover, Median MNCV did not change significantly over time. Conclusions: There was concordance between median MNCV and specific MPZ mutations.However, median M NCV is not an ideal measure with which to distinguish CMT1B patients with MPZ mu tations from CMT1A patients with PMP22 mutations.
文摘To describe the adverse effect of abdominal cramp caused by travoprost ophthalmic solution in a glaucoma patient. Case report. A 34- year-old woman reported abdominal cramp on topical application of travoprost ophthalmic solution. Satisfactory dechallenge and rechallenge procedures were performed. Abdominal cramp occurred approximately 30 minutes after topical application of travoprost on 3 consecutive days. No abdominal cramp developed after substitution of travoprost with latanoprost or normal saline (in the Travatan bottle). Abdominal cramps recurred on rechallenging with travoprost, either in the original Travatan bottle, a latanoprost bottle, or in a Rescula bottle. Flu-like symptoms (abdominal cramps, malaise and URI) were reported in 4% of patients participating in clinical trials of travoprost but seldom reported postmarketing. Based on the findings of dechallenge and rechallenge procedures, abdominal cramp should be considered a certain adverse effect of travoprost according to the WHO classification.
文摘Recurrence of endometrial cancer in the brain is a rare event generally accompanied by limi ted life expectancy.We present an unusual case of long -te rm survival follow-ing surgical resection of an intracranial endometrial cancer metastasis.The present case is a patient with FIGO stage IIB,grade III endometrial cancer which recurred 2months following completion of primary therapy with an isolated lesion in the brain.Aggressive trim odal therapy was initi-ated with curative intent and she has remained without clinical or radiographic evidence o f disease for more than30months following treatment of her recurrence.Aggres-sive multi -modal therapy is warrant ed in the treatment of isolated intracranial recurrences of endometrial cancer in carefully selected patients.With c omplete surgical resec-tion of disease,the precise nature a nd role of adjuvant treatment has yet to be clearly defin ed.
