After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal...After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal regeneration is re-growth of injured neurons themselves,but axons hardly regenerate in the adult mammalian CNS(Silver and Miller,2004).On the other hand,axonal sprouting is new growth from intact or spared neurons to the denervated target by forming axon collaterals,compensating for damaged circuits.This process is a more effective way for circuit remodeling,as it does not necessarily require long axonal elongation.展开更多
基金supported by MEXT KA KENHI on Dynamic Regulation of Brain Function by Scrap&Build System,No.16H06460 (to NY)JSPS KAKENHI Grant Nos.19H03325 (to NY) and 20J13844 (to LC)
文摘After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal regeneration is re-growth of injured neurons themselves,but axons hardly regenerate in the adult mammalian CNS(Silver and Miller,2004).On the other hand,axonal sprouting is new growth from intact or spared neurons to the denervated target by forming axon collaterals,compensating for damaged circuits.This process is a more effective way for circuit remodeling,as it does not necessarily require long axonal elongation.
