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下肢Gem citabin相关的硬皮病样改变
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作者 Bessis D. Guillot B. +2 位作者 legouffe e. Guilhou J. 阎小宁 《世界核心医学期刊文摘(皮肤病学分册)》 2005年第1期39-39,共1页
Gemcitabine is a nucleosid analog approved for use in the treatment of metastatic urothelial carcinoma of the bladder. We describe an unusual case of scleroderma-like changes of the lower extremities after treatment b... Gemcitabine is a nucleosid analog approved for use in the treatment of metastatic urothelial carcinoma of the bladder. We describe an unusual case of scleroderma-like changes of the lower extremities after treatment by gemcitabine for metastatic carcinoma of the bladder. The patient developed initial inflammatory edema (3 kg) restricted to the lower extremities and subsequent scleroderma-like changes after 2 cycles of gemcitabine. Cutaneous biopsy specimen revealed diffuse sclerosis without involvment of the fascia or muscle. Discontinuation of gemcitabine resulted in dramatic removal of the edema, softening of the skin, and partial reversibility of the fibrotic process. This is the first case report of a scleroderma-like reaction associated with gemcitabine. This antineoplastic agent must be added to the very limited number of cytostatic agents capable of giving rise to scleroderma-like features. 展开更多
关键词 硬皮病 GEM citabin 皮肤软化 核苷类似物 细胞抑制剂 弥漫性硬化 皮肤活检 抗癌药 罕见病例 感染性
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