[Objectives]To analyze the influence characteristics of surface water quality by agricultural non-point sources in Guigang City of Guangxi.[Methods]The daily concentration series of water quality indicators at three s...[Objectives]To analyze the influence characteristics of surface water quality by agricultural non-point sources in Guigang City of Guangxi.[Methods]The daily concentration series of water quality indicators at three state-controlled monitoring stations in Guigang City from^(2)019 to 2021 was analyzed by using Daubechies(db)wavelet,and Morlet wavelet was used to analyze the daily average concentration of water quality indicators.Continuous wavelet transform(CWT)was used to analyze the monthly concentration series of water quality indicators at three state-controlled monitoring stations in Guigang City from^(2)014 to 2021.[Results]The Daubechies(db)wavelet analysis showed that the concentrations of COD_(Mn),TP,and TN had the maximum values during June-July and October-November,and there were spatial differences among monitoring stations(COD_(Mn) concentration exceeding the standard was the most serious in Shizui,and DO concentration not up to standard was the most in Thermal Power Plant,and NH_(3)-N,TP and TN exceeding the standard was the most in Wulin Ferry).Morlet results showed that principal period of wavelet variance graphs of COD_(Mn),NH_(3)-N,and TP was 340 d,and there was the same sub-period of 140 d,and principal period of wavelet variance graph of DO was 260 d.CWT results showed that COD_(Cr) had similar resonance periods of about 1-2 and 5-7 months;BOD 5 and COD_(Mn) was dominant by the resonance period of 1-4 months(2014-2017);DO had a similar resonance period of about 1-3 months;NH_(3)-N was dominant by the resonance period of 1-5 months.[Conclusions]The surface water quality of Guigang City was mainly affected by the residual nitrogen and phosphorus nutrients and pesticide residues from agricultural production activities.展开更多
Asynchronous federated learning(AsynFL)can effectivelymitigate the impact of heterogeneity of edge nodes on joint training while satisfying participant user privacy protection and data security.However,the frequent ex...Asynchronous federated learning(AsynFL)can effectivelymitigate the impact of heterogeneity of edge nodes on joint training while satisfying participant user privacy protection and data security.However,the frequent exchange of massive data can lead to excess communication overhead between edge and central nodes regardless of whether the federated learning(FL)algorithm uses synchronous or asynchronous aggregation.Therefore,there is an urgent need for a method that can simultaneously take into account device heterogeneity and edge node energy consumption reduction.This paper proposes a novel Fixed-point Asynchronous Federated Learning(FixedAsynFL)algorithm,which could mitigate the resource consumption caused by frequent data communication while alleviating the effect of device heterogeneity.FixedAsynFL uses fixed-point quantization to compress the local and global models in AsynFL.In order to balance energy consumption and learning accuracy,this paper proposed a quantization scale selection mechanism.This paper examines the mathematical relationship between the quantization scale and energy consumption of the computation/communication process in the FixedAsynFL.Based on considering the upper bound of quantization noise,this paper optimizes the quantization scale by minimizing communication and computation consumption.This paper performs pertinent experiments on the MNIST dataset with several edge nodes of different computing efficiency.The results show that the FixedAsynFL algorithm with an 8-bit quantization can significantly reduce the communication data size by 81.3%and save the computation energy in the training phase by 74.9%without significant loss of accuracy.According to the experimental results,we can see that the proposed AsynFixedFL algorithm can effectively solve the problem of device heterogeneity and energy consumption limitation of edge nodes.展开更多
Interfacial solar steam generation(ISSG)is a novel and potential solution to global freshwater crisis.Here,based on a facile sol-gel fabrication process,we demonstrate a highly scalable Janus aramid nanofiber aerogel(...Interfacial solar steam generation(ISSG)is a novel and potential solution to global freshwater crisis.Here,based on a facile sol-gel fabrication process,we demonstrate a highly scalable Janus aramid nanofiber aerogel(JANA)as a high-efficiency ISSG device.JANA performs near-perfect broadband optical absorption,rapid photothermal conversion and effective water transportation.Owning to these features,efficient desalination of salty water and purification of municipal sewage are successfully demonstrated using JANA.In addition,benefiting from the mechanical property and chemical stability of constituent aramid nanofibers,JANA not only possesses outstanding flexibility and fire-resistance properties,but its solar steaming efficiency is also free from the influences of elastic deformations and fire treatments.We envision JANA provides a promising platform for mass-production of high-efficiency ISSG devices with supplementary capabilities of convenient transportation and long-term storage,which could further promote the realistic applications of ISSG technology.展开更多
OBJECTIVES To assess the correlation between triglyceride glucose(TyG)index and in-hospital mortality in patients with ST-segment elevation myocardial infarction(STEMI).METHODS A total of 2190 patients with STEMI who ...OBJECTIVES To assess the correlation between triglyceride glucose(TyG)index and in-hospital mortality in patients with ST-segment elevation myocardial infarction(STEMI).METHODS A total of 2190 patients with STEMI who underwent primary angiography within 12 h from symptom onset were selected from the prospective,nationwide,multicenter CAMI registry.TyG index was calculated with the formula:Ln[fasting triglycerides(mmol/L)×fasting glucose(mmol/L)/2].Patients were divided into three groups according to the tertiles of TyG index.The primary endpoint was in-hospital mortality.RESULTS Overall,46 patients died during hospitalization,in-hospital mortality was 1.5%,2.2%,2.6%for tertile 1,tertile 2,and tertile 3,respectively.However,TyG index was not significantly correlated with in-hospital mortality in single-variable logistic regression analysis.Nonetheless,after adjusting for age and sex,TyG index was significantly associated with higher mortality when regarded as a continuous variable(adjusted OR=1.75,95%CI:1.16-2.63)or categorical variable(tertile 3 vs.tertile 1:adjus-ted OR=2.50,95%CI:1.14-5.49).Furthermore,TyG index,either as a continuous variable(adjusted OR=2.54,95%CI:1.42-4.54)or categorical variable(tertile 3 vs.tertile 1:adjusted OR=3.57,95%CI:1.24-10.29),was an independent predictor of in-hospital mortality after adjusting for multiple confounders in multivariable logistic regression analysis.In subgroup analysis,the pro-gnostic effect of high TyG index was more significant in patients with body mass index<18.5 kg/m2(P interaction=0.006).CONCLUSIONS This study showed that TyG index was positively correlated with in-hospital mortality in STEMI patients who underwent primary angiography,especially in underweight patients.展开更多
As the scale of the power system continues to expand,the environment for power operations becomes more and more complex.Existing risk management and control methods for power operations can only set the same risk dete...As the scale of the power system continues to expand,the environment for power operations becomes more and more complex.Existing risk management and control methods for power operations can only set the same risk detection standard and conduct the risk detection for any scenario indiscriminately.Therefore,more reliable and accurate security control methods are urgently needed.In order to improve the accuracy and reliability of the operation risk management and control method,this paper proposes a method for identifying the key links in the whole process of electric power operation based on the spatiotemporal hybrid convolutional neural network.To provide early warning and control of targeted risks,first,the video stream is framed adaptively according to the pixel changes in the video stream.Then,the optimized MobileNet is used to extract the feature map of the video stream,which contains both time-series and static spatial scene information.The feature maps are combined and non-linearly mapped to realize the identification of dynamic operating scenes.Finally,training samples and test samples are produced by using the whole process image of a power company in Xinjiang as a case study,and the proposed algorithm is compared with the unimproved MobileNet.The experimental results demonstrated that the method proposed in this paper can accurately identify the type and start and end time of each operation link in the whole process of electric power operation,and has good real-time performance.The average accuracy of the algorithm can reach 87.8%,and the frame rate is 61 frames/s,which is of great significance for improving the reliability and accuracy of security control methods.展开更多
BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed tha...BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations.However,the specific gut microbiota differences between the two populations have not been elucidated.AIM To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.METHODS A total of 35 subjects of the Han population(including 15 healthy children,8 adult healthy controls,and 12 adult T2DM patients)and 32 subjects of the Dai population(including 10 healthy children,10 adult healthy controls,and 12 adult T2DM patients)were enrolled in this study.Fasting venous blood samples were collected from all the subjects for biochemical analysis.Fecal samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing,which was followed by analyses of the gut microbiota composition.RESULTS No significant difference in alpha diversity was observed between healthy children and adults.The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Hanpopulation with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, thisdifference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteriain the Dai population and decreases in Firmicutes in both the Han and Dai population were observed inT2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that thegut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients.Four bacteria were consistently increased and two consistently decreased in the Han population compared to theDai population.CONCLUSION Differences in gut microbiota were found between the Han and Dai populations. A significant increase inBacteroidetes was related to the occurrence of T2DM in the Han population, while a significant increase in Proteobacteriawas related to the occurrence of T2DM in the Dai population.展开更多
This article aims to address the clustering effect caused by unorganized charging of electric vehicles by adopting a two-tier recommendation method.The electric vehicles(EVs)are classified into high-level alerts and g...This article aims to address the clustering effect caused by unorganized charging of electric vehicles by adopting a two-tier recommendation method.The electric vehicles(EVs)are classified into high-level alerts and general alerts based on their state of charge(SOC).EVs with high-level alerts have the most urgent charging needs,so the distance to charging stations is set as the highest priority for recommendations.For users with general alerts,a comprehensive EV charging station recommendation model is proposed,taking into account factors such as charging price,charging time,charging station preference,and distance to the charging station.Using real data from EV charging stations and ride-hailing vehicles in Xiamen City,Fujian Province,simulation analyses are conducted using Python for different periods of the day.The research results show that the stability of the multi-factor recommendation model in terms of service density variance,coverage rate,price cost,and distance cost outperform single-factor models.This indicates that our composite multi-factor recommendation model has significant practical value in resolving the clustering phenomenon caused by unorganized EV charging,optimizing the EV charging service system,and improving user satisfaction.展开更多
目的:比较局部晚期宫颈癌采用标准三管施源器的腔内后装(tandem and ovoid)与腔内结合组织间插植后装的剂量学差异。方法:CT引导下的三维适形近距离治疗局部晚期宫颈癌患者20例,间隔采用三管式腔内后装与腔内结合组织间插植共72次。按...目的:比较局部晚期宫颈癌采用标准三管施源器的腔内后装(tandem and ovoid)与腔内结合组织间插植后装的剂量学差异。方法:CT引导下的三维适形近距离治疗局部晚期宫颈癌患者20例,间隔采用三管式腔内后装与腔内结合组织间插植共72次。按照施源器的不同分成2个组,每组36次,对靶区剂量、危及器官等进行比较。结果:在给予A点相同处方剂量的情况下,HR-CTV D90、D100在三管式腔内后装组与腔内结合组织间插植后装组中分别为(590.0±46.4)cGy、(471.2±66.2)cGy,(502.8±67.7)cGy、(335.9±46.0)cGy,P<0.05),膀胱、直肠、乙状结肠D2cc均相近(P=0.85、0.28、0.53)。结论:采用腔内结合插植后装治疗局部晚期宫颈癌比三管式腔内后装可获得更高的靶区剂量,但长期疗效及晚期反应仍需进一步研究。展开更多
Ischemic stroke(IS)is the main killer that endangers the health and life of middle-aged and elderly people worldwide.Inflammatory response plays a key regulatory role in the pathogenesis of IS.After cerebral ischemia,...Ischemic stroke(IS)is the main killer that endangers the health and life of middle-aged and elderly people worldwide.Inflammatory response plays a key regulatory role in the pathogenesis of IS.After cerebral ischemia,leukocytes rapidly accumulate,penetrate blood vessels and infiltrate brain tissue,thereby activating pro-inflammatory factors in the infarct area to exacerbate nerve damage.Neutrophil extracellular traps(NETs)are fibrous mesh structures released by activated neutrophils outside the cell,which can clear pathogens and cell debris,induce inflammatory responses and exacerbate cerebral ischemia-reperfusion(CI/R)injury.Various traditional Chinese medicines and their main components can improve neurological function defects after IS,and inhibit the formation of NETs,which opens up a new direction for the study of traditional Chinese medicines in the prevention and treatment of IS.展开更多
基金Supported by Basic Scientific Research Ability Improvement Project of Young and Middle-aged Teachers in Guangxi Colleges and Universities in 2021(2021KY1970).
文摘[Objectives]To analyze the influence characteristics of surface water quality by agricultural non-point sources in Guigang City of Guangxi.[Methods]The daily concentration series of water quality indicators at three state-controlled monitoring stations in Guigang City from^(2)019 to 2021 was analyzed by using Daubechies(db)wavelet,and Morlet wavelet was used to analyze the daily average concentration of water quality indicators.Continuous wavelet transform(CWT)was used to analyze the monthly concentration series of water quality indicators at three state-controlled monitoring stations in Guigang City from^(2)014 to 2021.[Results]The Daubechies(db)wavelet analysis showed that the concentrations of COD_(Mn),TP,and TN had the maximum values during June-July and October-November,and there were spatial differences among monitoring stations(COD_(Mn) concentration exceeding the standard was the most serious in Shizui,and DO concentration not up to standard was the most in Thermal Power Plant,and NH_(3)-N,TP and TN exceeding the standard was the most in Wulin Ferry).Morlet results showed that principal period of wavelet variance graphs of COD_(Mn),NH_(3)-N,and TP was 340 d,and there was the same sub-period of 140 d,and principal period of wavelet variance graph of DO was 260 d.CWT results showed that COD_(Cr) had similar resonance periods of about 1-2 and 5-7 months;BOD 5 and COD_(Mn) was dominant by the resonance period of 1-4 months(2014-2017);DO had a similar resonance period of about 1-3 months;NH_(3)-N was dominant by the resonance period of 1-5 months.[Conclusions]The surface water quality of Guigang City was mainly affected by the residual nitrogen and phosphorus nutrients and pesticide residues from agricultural production activities.
基金This work was funded by National Key R&D Program of China(Grant No.2020YFB0906003).
文摘Asynchronous federated learning(AsynFL)can effectivelymitigate the impact of heterogeneity of edge nodes on joint training while satisfying participant user privacy protection and data security.However,the frequent exchange of massive data can lead to excess communication overhead between edge and central nodes regardless of whether the federated learning(FL)algorithm uses synchronous or asynchronous aggregation.Therefore,there is an urgent need for a method that can simultaneously take into account device heterogeneity and edge node energy consumption reduction.This paper proposes a novel Fixed-point Asynchronous Federated Learning(FixedAsynFL)algorithm,which could mitigate the resource consumption caused by frequent data communication while alleviating the effect of device heterogeneity.FixedAsynFL uses fixed-point quantization to compress the local and global models in AsynFL.In order to balance energy consumption and learning accuracy,this paper proposed a quantization scale selection mechanism.This paper examines the mathematical relationship between the quantization scale and energy consumption of the computation/communication process in the FixedAsynFL.Based on considering the upper bound of quantization noise,this paper optimizes the quantization scale by minimizing communication and computation consumption.This paper performs pertinent experiments on the MNIST dataset with several edge nodes of different computing efficiency.The results show that the FixedAsynFL algorithm with an 8-bit quantization can significantly reduce the communication data size by 81.3%and save the computation energy in the training phase by 74.9%without significant loss of accuracy.According to the experimental results,we can see that the proposed AsynFixedFL algorithm can effectively solve the problem of device heterogeneity and energy consumption limitation of edge nodes.
基金jointly supported by the National Natural Science Foundation of China (no. 62105142)Natural Science Foundation of Jiangsu Province (BK20220068)+1 种基金the Center Fundamental Research Funds for the Central UniversitiesEntrepreneurship and Innovation Program of Jiangsu Province (JSSCBS20210002)。
文摘Interfacial solar steam generation(ISSG)is a novel and potential solution to global freshwater crisis.Here,based on a facile sol-gel fabrication process,we demonstrate a highly scalable Janus aramid nanofiber aerogel(JANA)as a high-efficiency ISSG device.JANA performs near-perfect broadband optical absorption,rapid photothermal conversion and effective water transportation.Owning to these features,efficient desalination of salty water and purification of municipal sewage are successfully demonstrated using JANA.In addition,benefiting from the mechanical property and chemical stability of constituent aramid nanofibers,JANA not only possesses outstanding flexibility and fire-resistance properties,but its solar steaming efficiency is also free from the influences of elastic deformations and fire treatments.We envision JANA provides a promising platform for mass-production of high-efficiency ISSG devices with supplementary capabilities of convenient transportation and long-term storage,which could further promote the realistic applications of ISSG technology.
基金supported by CAMS Innovation Fund for Medical Sciences(CIFMS:2021-I2M-1-008)Beijing Municipal Health Commission-Capital Health Development Research Project(2020-1-4032)+1 种基金Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS:2020-I2M-C&TB-056)the Twelfth Five-Year Planning Project of the Scientific and Technological Department of China(2011BAI11B02).
文摘OBJECTIVES To assess the correlation between triglyceride glucose(TyG)index and in-hospital mortality in patients with ST-segment elevation myocardial infarction(STEMI).METHODS A total of 2190 patients with STEMI who underwent primary angiography within 12 h from symptom onset were selected from the prospective,nationwide,multicenter CAMI registry.TyG index was calculated with the formula:Ln[fasting triglycerides(mmol/L)×fasting glucose(mmol/L)/2].Patients were divided into three groups according to the tertiles of TyG index.The primary endpoint was in-hospital mortality.RESULTS Overall,46 patients died during hospitalization,in-hospital mortality was 1.5%,2.2%,2.6%for tertile 1,tertile 2,and tertile 3,respectively.However,TyG index was not significantly correlated with in-hospital mortality in single-variable logistic regression analysis.Nonetheless,after adjusting for age and sex,TyG index was significantly associated with higher mortality when regarded as a continuous variable(adjusted OR=1.75,95%CI:1.16-2.63)or categorical variable(tertile 3 vs.tertile 1:adjus-ted OR=2.50,95%CI:1.14-5.49).Furthermore,TyG index,either as a continuous variable(adjusted OR=2.54,95%CI:1.42-4.54)or categorical variable(tertile 3 vs.tertile 1:adjusted OR=3.57,95%CI:1.24-10.29),was an independent predictor of in-hospital mortality after adjusting for multiple confounders in multivariable logistic regression analysis.In subgroup analysis,the pro-gnostic effect of high TyG index was more significant in patients with body mass index<18.5 kg/m2(P interaction=0.006).CONCLUSIONS This study showed that TyG index was positively correlated with in-hospital mortality in STEMI patients who underwent primary angiography,especially in underweight patients.
基金This paper is supported by the Science and technology projects of Yunnan Province(Grant No.202202AD080004).
文摘As the scale of the power system continues to expand,the environment for power operations becomes more and more complex.Existing risk management and control methods for power operations can only set the same risk detection standard and conduct the risk detection for any scenario indiscriminately.Therefore,more reliable and accurate security control methods are urgently needed.In order to improve the accuracy and reliability of the operation risk management and control method,this paper proposes a method for identifying the key links in the whole process of electric power operation based on the spatiotemporal hybrid convolutional neural network.To provide early warning and control of targeted risks,first,the video stream is framed adaptively according to the pixel changes in the video stream.Then,the optimized MobileNet is used to extract the feature map of the video stream,which contains both time-series and static spatial scene information.The feature maps are combined and non-linearly mapped to realize the identification of dynamic operating scenes.Finally,training samples and test samples are produced by using the whole process image of a power company in Xinjiang as a case study,and the proposed algorithm is compared with the unimproved MobileNet.The experimental results demonstrated that the method proposed in this paper can accurately identify the type and start and end time of each operation link in the whole process of electric power operation,and has good real-time performance.The average accuracy of the algorithm can reach 87.8%,and the frame rate is 61 frames/s,which is of great significance for improving the reliability and accuracy of security control methods.
基金the National Natural Science Foundation of China,No.82160402Special Fund for Training Leading Medical Talents in Yunnan Province,China,No.L-2019022。
文摘BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations.However,the specific gut microbiota differences between the two populations have not been elucidated.AIM To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.METHODS A total of 35 subjects of the Han population(including 15 healthy children,8 adult healthy controls,and 12 adult T2DM patients)and 32 subjects of the Dai population(including 10 healthy children,10 adult healthy controls,and 12 adult T2DM patients)were enrolled in this study.Fasting venous blood samples were collected from all the subjects for biochemical analysis.Fecal samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing,which was followed by analyses of the gut microbiota composition.RESULTS No significant difference in alpha diversity was observed between healthy children and adults.The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Hanpopulation with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, thisdifference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteriain the Dai population and decreases in Firmicutes in both the Han and Dai population were observed inT2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that thegut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients.Four bacteria were consistently increased and two consistently decreased in the Han population compared to theDai population.CONCLUSION Differences in gut microbiota were found between the Han and Dai populations. A significant increase inBacteroidetes was related to the occurrence of T2DM in the Han population, while a significant increase in Proteobacteriawas related to the occurrence of T2DM in the Dai population.
基金the Jiangsu Provincial College Students Innovation and Entrepreneurship Training Plan Project(Grant Number 202311276097Y).
文摘This article aims to address the clustering effect caused by unorganized charging of electric vehicles by adopting a two-tier recommendation method.The electric vehicles(EVs)are classified into high-level alerts and general alerts based on their state of charge(SOC).EVs with high-level alerts have the most urgent charging needs,so the distance to charging stations is set as the highest priority for recommendations.For users with general alerts,a comprehensive EV charging station recommendation model is proposed,taking into account factors such as charging price,charging time,charging station preference,and distance to the charging station.Using real data from EV charging stations and ride-hailing vehicles in Xiamen City,Fujian Province,simulation analyses are conducted using Python for different periods of the day.The research results show that the stability of the multi-factor recommendation model in terms of service density variance,coverage rate,price cost,and distance cost outperform single-factor models.This indicates that our composite multi-factor recommendation model has significant practical value in resolving the clustering phenomenon caused by unorganized EV charging,optimizing the EV charging service system,and improving user satisfaction.
文摘目的:比较局部晚期宫颈癌采用标准三管施源器的腔内后装(tandem and ovoid)与腔内结合组织间插植后装的剂量学差异。方法:CT引导下的三维适形近距离治疗局部晚期宫颈癌患者20例,间隔采用三管式腔内后装与腔内结合组织间插植共72次。按照施源器的不同分成2个组,每组36次,对靶区剂量、危及器官等进行比较。结果:在给予A点相同处方剂量的情况下,HR-CTV D90、D100在三管式腔内后装组与腔内结合组织间插植后装组中分别为(590.0±46.4)cGy、(471.2±66.2)cGy,(502.8±67.7)cGy、(335.9±46.0)cGy,P<0.05),膀胱、直肠、乙状结肠D2cc均相近(P=0.85、0.28、0.53)。结论:采用腔内结合插植后装治疗局部晚期宫颈癌比三管式腔内后装可获得更高的靶区剂量,但长期疗效及晚期反应仍需进一步研究。
文摘Ischemic stroke(IS)is the main killer that endangers the health and life of middle-aged and elderly people worldwide.Inflammatory response plays a key regulatory role in the pathogenesis of IS.After cerebral ischemia,leukocytes rapidly accumulate,penetrate blood vessels and infiltrate brain tissue,thereby activating pro-inflammatory factors in the infarct area to exacerbate nerve damage.Neutrophil extracellular traps(NETs)are fibrous mesh structures released by activated neutrophils outside the cell,which can clear pathogens and cell debris,induce inflammatory responses and exacerbate cerebral ischemia-reperfusion(CI/R)injury.Various traditional Chinese medicines and their main components can improve neurological function defects after IS,and inhibit the formation of NETs,which opens up a new direction for the study of traditional Chinese medicines in the prevention and treatment of IS.