Study on Bacteriostatic Properties of Piroctone Olamine in Commonly Used Surfactants Systems

Piroctone olamine(OCT) was used as the main bacteriostatic component, the inhibition of OCT in different kinds and mass concentrations of surfactants were studied. Six surfactants commonly used in personal care products, i.e. sodium laureth sulfate(AES), cocamidopropyl betaine(CAB 35), sodium lauroyl sarcosinate(LS-30), sodium lauroyl glutamate(ULS-30S), alkyl glycoside(APG), cocamide methyl MEA(CMMEA),were used. The results showed that the bacteriostatic of OCT decreased with the increase of AES, which was suggested ≤ 5%. OCT has good bacteriostatic performance in the systems of amino acid surfactants and high dosage of amphoteric surfactants, 5% LS 30 and ≥ 10% CAB 35 was recommended. High dosage of nonionic surfactant could interfere the bacteriostatic performance of OCT, the recommended dosage was ≤ 2%.In addition, OCT has good bacteriostatic performance against Staphylococcus aureus, Escherichia coli and Candida albicans when pH was controlled less than 5.5.

无患子皂苷抗炎抗菌功效研究

目的:研究无患子皂苷的抗炎和抑菌效果。方法:从无患子果皮中分离出无患子总皂苷,通过佛波酯(TPA)诱导的小鼠耳肿胀模型评价无患子皂苷对小鼠耳厚度、组织病理和炎症因子TNF-α、IL-6、IL-1β含量的影响,并采用最小抑菌浓度法(MIC)评价其抑菌活性。结果:与模型组相比,各剂量组均能显著降低小鼠耳厚度;无患子皂苷能够改善耳组织中的炎症细胞浸润,显著降低TNF-α、IL-6含量,但对IL-1β含量无影响。无患子皂苷对测试的9个菌种中的8种菌具有较好的抑菌能力,其中对须癣毛癣菌抑菌活性最好,MIC值为0.005 mg/mL。结论:无患子皂苷对TPA诱导的小鼠耳肿胀模型具有较好的抗炎活性,并对多种菌有抑菌能力。