Application of Fluid Phase Recovery Method in the Early Development of BZ26-6 Volatile Oil Field in Bohai Sea

BZ26-6 Oilfield is a kind of deep metamorphic rock buried-hill volatile oilfield in Bohai Sea, China. Its early development plan is restricted due to the simultaneous production of oil and gas in large sections of reservoirs, unclear understanding of formation fluid properties and uncertainty of gas-oil interface. Through theoretical research on phase recovery and experimental analysis of crude oil phase characteristics in the original formation, characteristic parameters of the equilibrium condensate gas fluid are restored and calculated. Through the superimposed phase diagram of volatile oil and condensate gas, BZ26-6 Oilfield is determined to be a volatile oil reservoir with a condensate gas cap, with formation pressure and saturation pressure of 36.1 MPa, respectively. Based on the research results of oil-gas phase behavior characteristics, the thermodynamic equations and equation of state are jointly used to solve the problem, and the content change curves of each component at different depths are drawn. Combined with the sensitivity analysis of numerical simulation, the gas-oil interface is determined to be -3726 m above sea level. The fluid phase analysis software, Fluidmodeler, is used to simulate volatile oil degassing and condensate gas separation experiments. In combination with oil and gas production data obtained through the production test, the specific oil recovery index and the specific gas recovery index are determined to be 0.408 m3/(MPa·d·m) and 1195 m3/(MPa·d·m), respectively. And the reasonable production capacity prediction is conducted on the early development of BZ26-6 Oilfield. The research results can provide a theoretical basis for the efficient development of similar complex oil and gas reservoirs.

喹啉类化合物的合成及其结构对阴离子比色传感性能影响研究——介绍一个研究型综合实验项目

介绍了一个研究型综合实验项目——喹啉类化合物的合成及其结构对阴离子比色传感性能影响研究。在本实验中,学生将学习并掌握喹啉类杂环化合物及其衍生物的合成方法以及表征手段。学生在理解有机小分子传感识别原理的基础上,学会利用紫外-可见吸收光谱仪研究喹啉类化合物作为探针(P1、P2、P3)对阴离子传感识别性能。通过Origin软件处理的光谱数据以及可视化的比色图像,让学生更加直观地比较不同探针的阴离子传感识别性能,深入理解探针的分子结构影响和控制其传感性能的重要性。

A Bilayer High-Temperature Dielectric Film with Superior Breakdown Strength and Energy Storage Density

The further electrification of various fields in production and daily life makes it a topic worthy of exploration to improve the performance of capacitors for a long time,including thin-film capacitors.The discharge energy density of thin-film capacitors that serves as one of the important types directly depends on electric field strength and the dielectric constant of the insulation material.However,it has long been a great challenge to improve the breakdown strength and dielectric constant simultaneously.Considering that boron nitride nanosheets(BNNS)possess superior insulation and thermal conductivity owing to wide band gap and 2-dimensional structure,a bilayer polymer film is prepared via coating BNNS by solution casting on surface of polyethylene terephthalate(PET)films.By revealing the bandgap and insulating behavior with UV absorption spectrum,leakage current,and finite element calculation,it is manifested that nanocoating contributes to enhance the bandgap of polymer films,thereby suppressing the charge injection by redirecting their transport from electrodes.Worthy to note that an ultrahigh breakdown field strength(~736 MV m^(−1)),an excellent discharge energy density(~8.77 J cm^(−3))and a prominent charge-discharge efficiency(~96.51%)are achieved concurrently,which is ascribed to the contribution of BNNS ultrathin layer.In addition,the modified PET films also have superior comprehensive performance at high temperatures(~120°C).The materials and methods here selected are easily accessible and facile,which are suitable for large-scale roll-to-roll process production,and are of certain significance to explore the methods about film modification suitable for commercial promotion.

Explosion characteristics of aluminum-based activated fuels containing fluorine

Measuring the dust explosion characteristics of aluminum-based activated fuels was a prerequisite for developing effective prevention and control measures.In this paper,ignition sensitivity,flame propagation behaviors and explosion severity of aluminum/polytetrafluoroethylene(Al/PTFE)compositions including 2 PT(2.80 wt.%F),4 PT(7.18 wt.%F)and 8 PT(11.90 wt.%F)were studied.When the content of F increased from 2.80 wt.%to 11.90 wt.%,the minimum explosive concentration MEC decreased from380 g/m^(3)to 140 g/m^(3),due to the dual effects of increased internal active aluminum and enhanced reactivity.The average flame propagation velocities increased as the percentage of F increased.The maximum explosion pressure Pmof 500 g/m3aluminum-based activated fuels increased from 247 k Pa to299 kPa.Scanning electron microscopy demonstrated that with the increase of PTFE content,the reaction was more complete.On this basis,the explosion mechanism of aluminum-based activated fuels was revealed.

Functional analysis of flavanone 3-hydroxylase(F3H)from Dendrobium officinale,which confers abiotic stress tolerance

Flavonoids are important bioactive components in Dendrobium officinale,a medicinal orchid.They are involved in many biological activities,including protecting plants against biotic and abiotic stresses.Research on the key genes related to flavonoid biosynthesis in D.officinale is limited.In this study,one of the key flavonoid biosynthesis genes,flavanone 3-hydroxylase(F3H),was characterized from D.officinale.The open reading frame of DoF3H was 1134 bp long and it encoded a 377-amino acid protein.The DoF3H protein showed considerably high homology with F3H proteins from other plant species and shared a common evolutionary ancestor with other F3Hs.DoF3H transcripts were detected in different organs of adult plants and mainly accumulated in flowers,followed by roots,stems and leaves,a pattern that was similar to the content of flavonoids.Recombinant DoF3H protein,which was localized in the cytosol,could convert naringenin to dihydrokaempferol.The mRNA levels of DoF3H were significantly induced by salt and cold stresses.Furthermore,the heterologous expression of DoF3H in Escherichia coli conferred it higher tolerance to salt and cold stresses.These results provide insight into the molecular function of DoF3H in the biosynthesis of flavonoids,and provide a new application for improvement of abiotic tolerance in D.officinale.

Magnetic Activity and Parameters of 43 Flare Stars in the GWAC Archive

In the archive of the Ground Wide Angle Camera(GWAC),we found 43 white light flares from 43 stars,among which,three are sympathetic or homologous flares,and one of them also has a quasi-periodic pulsation with a period of 13.0±1.5 minutes.Among these 43 flare stars,there are 19 new active stars and 41 stars that have available TESS and/or K2 light curves,from which we found 931 stellar flares.We also obtained rotational or orbital periods of 34 GWAC flare stars,of which 33 are less than 5.4 days,and ephemerides of three eclipsing binaries from these light curves.Combining with low resolution spectra from LAMOST and the Xinglong 2.16 m telescope,we found that L_(Hα)/L_(bol) are in the saturation region in the rotation-activity diagram.From the LAMOST medium-resolution spectrum,we found that Star#3(HAT 178-02667)has double Hαemissions which imply it is a binary,and two components are both active stars.Thirteen stars have flare frequency distributions(FFDs)from TESS and/or K2 light curves.These FFDs show that the flares detected by GWAC can occur at a frequency of 0.5to 9.5 yr^(-1).The impact of flares on habitable planets was also studied based on these FFDs,and flares from some GWAC flare stars may produce enough energetic flares to destroy ozone layers,but none can trigger prebiotic chemistry on their habitable planets.

Enhanced mechanical and thermal properties of two-dimensional SiC and GeC with temperature and size dependence

Two-dimensional materials with novel mechanical and thermal properties are available for sensors,photodetectors,thermoelectric,crystal diode and flexible nanodevices.In this investigation,the mechanical and thermal properties of pristine SiC and GeC are explored by molecular dynamics simulations.First,the fracture strength and fracture strain behaviors are addressed in the zigzag and armchair directions at 300 K.The excellent toughness of SiC and GeC is demonstrated by the maximal fracture strain of 0.43 and 0.47 in the zigzag direction,respectively.The temperature-tunable tensile strength of SiC and GeC is also investigated.Then,using non-equilibrium molecular dynamics(NEMD)calculations,the thermal performances of SiC and GeC are explored.In particular,the thermal conductivity of SiC and GeC shows a pronounced size dependence and reaches up to 85.67 W·m^(-1)-K^(-1)and 34.37 W·m^(-1)-K^(-1),respectively.The goal of our work is to provide a theoretical framework that can be used in the near future.This will enable us to design an efficient thermal management scheme for two-dimensional materials in electronics and optoelectronics.

MSCNN-LSTM Model for Predicting Return Loss of the UHF Antenna in HF-UHF RFID Tag Antenna

High-frequency(HF)and ultrahigh-frequency(UHF)dual-band radio frequency identification(RFID)tags with both near-field and farfield communication can meet different application scenarios.However,it is time-consuming to calculate the return loss of a UHF antenna in a dualband tag antenna using electromagnetic(EM)simulators.To overcome this,the present work proposes a model of a multi-scale convolutional neural network stacked with long and short-term memory(MSCNN-LSTM)for predicting the return loss of UHF antennas instead of EM simulators.In the proposed MSCNN-LSTM,the MSCNN has three branches,which include three convolution layers with different kernel sizes and numbers.Therefore,MSCNN can extract fine-grain localized information of the antenna and overall features.The LSTM can effectively learn the EM characteristics of different structures of the antenna to improve the prediction accuracy of the model.Experimental results show that the mean absolute error(0.0073),mean square error(0.00032),and root mean square error(0.01814)of theMSCNNLSTM are better than those of other prediction methods.In predicting the return loss of 100UHFantennas,compared with the simulation time of 4800 s for High Frequency Structure Simulator(HFSS),MSCNN-LSTM takes only 0.927519 s under the premise of ensuring prediction accuracy,significantly reducing the calculation time,which provides a basis for the rapid design of HF-UHF RFID tag antenna.ThenMSCNN-LSTM is used to determine the dimensions of the UHF antenna quickly.The return loss of the designed dualband RFID tag antenna is−58.76 and−22.63 dB at 13.56 and 915 MHz,respectively,achieving the desired goal.

A super resolution target separation and reconstruction approach for single channel sar against deceptive jamming

The excellent remote sensing ability of synthetic aperture radar(SAR)will be misled seriously when it encounters deceptive jamming which possesses high fidelity and fraudulence.In this paper,the dynamic synthetic aperture(DSA)scheme is used to extract the difference between the true and false targets.A simultaneous deceptive jamming suppression and target reconstruction method is proposed for a single channel SAR system to guarantee remote sensing ability.The system model is formulated as a sparse signal recovery problem with an unknown parametric dictionary to be estimated.An iterative reweighted method is employed to jointly handle the dictionary parameter learning and target reconstruction problem in an majorization-minimization framework,where a surrogate function majorizing the Gaussian entropy in the objective function is introduced to circumvent its non-convexity.After dictionary parameter learning,the grid mismatching problem in a fixed grid based method is avoided.Therefore,the proposed method can reap a super resolution result.Besides,a simple yet effective DSA section scheme is developed for the SAR data excerpting,in which only two DSAs are required.Experimental results about location error and reconstruction power error reveal that the proposed method is able to achieve a good performance in deceptive jamming suppression.

Multimodal MRI diagnosis and transvenous embolization of a basicranial emissary vein dural arteriovenous fistula:A case report

A dural arteriovenous fistula(DAVF) is an abnormal linkage connecting the arterial and venous systems within the intracranial dura mater. A basicranial emissary vein DAVF drains into the cavernous sinus and the ophthalmic vein, similar to a cavernous sinus DAVF. Precise preoperative identification of the DAVF location is a prerequisite for appropriate treatment. Treatment options include microsurgical disconnection, endovascular transarterial embolization(TAE), transvenous embolization(TVE), or a combination thereof. TVE is an increasingly popular approach for the treatment of DAVFs and the preferred approach for skull base locations, due to the risk of cranial neuropathy caused by dangerous anastomosis from arterial approaches. Multimodal magnetic resonance imaging(MRI) can provide anatomical and hemodynamic information for TVE. The therapeutic target must be precisely embolized in the emissary vein, which requires guidance via multimodal MRI. Here, we report a rare case of successful TVE for a basicranial emissary vein DAVF, utilizing multimodal MRI assistance. The fistula had vanished, pterygoid plexus drainage had improved, and the inferior petrosal sinus had recanalized, as observed on 8-month follow-up angiography. Symptoms and signs of double vision, caused by abduction deficiency, disappeared. Detailed anatomic and hemodynamic assessment by multimodal MRI is the key to guiding successful diagnosis and treatment.

Progress in Diagnosis and Treatment of Small Intestinal Bacterial Overgrowth

Small intestinal bacterial overgrowth has been found to be associated with a variety of gastrointestinal disorders such as irritable bowel syndrome, inflammatory bowel disease, and, in recent years, diabetes mellitus and systemic sclerosis, among other extraintestinal diseases. Several novel diagnostic tools for small intestinal bacterial overgrowth have emerged in recent years, and several therapeutic approaches have been proposed. Therefore, it has become necessary to find an effective, safe, and simple diagnostic method and a safe treatment modality. This article provides a review of current diagnostic and therapeutic approaches to small intestinal bacterial overgrowth.

Rifaximin in the Treatment of Gastroesophageal Reflux Disease: A New Idea Based on the Relationship between Intestinal Microecology and Gastroesophageal Reflux Disease

Rifaximin in the Treatment of Gastroesophageal Reflux Disease (GERD) is a common clinical disorder, the most common symptom of which is a burning sensation behind the breastbone (heartburn) or reflux of stomach contents into the upper pharynx (acid reflux). The prevalence in China is increasing year by year, which can affect the quality of life of patients and also increase the economic burden on families and society. The pathogenesis of GERD is still unclear, and some studies suggest that intestinal microecology may be closely related to the development of GERD. Rifaximin is not readily absorbed orally and acts locally in the intestine, so it has mild adverse effects and good safety, and can be used to treat gastrointestinal diseases such as irritable bowel syndrome, traveler’s diarrhea, small intestinal bacterial overgrowth, diverticulosis, inflammatory bowel disease and hepatic encephalopathy. Therefore, this paper focuses on intestinal microecology as a possible pathogenesis of GERD and further explores the feasibility of rifaximin for the treatment of GERD.

Insight into the Permeability and Microstructure Evolution Mechanism of the Sliding Zone Soil: A Case Study from the Huangtupo Landslide, Three Gorges Reservoir, China

A large number of laboratory investigations related to the permeability have been conducted on the sliding zones.Yet little attention has been paid to the particular sliding zones of the slideprone Badong Formation.Here,we experimentally investigate the permeability nature and the mechanism of seepage in the viscous sliding zone of the Huangtupo Landslide.Saturated seepage tests have been performed first with consideration of six dry densities and thirteen hydraulic gradients,in conjunction with the mercury intrusion porosimetry test and scanning electron microscopy test for the microstructure analysis after seepage.The results show that seepage in the sliding zone soil does not follow Darcy’s Law,since there is a threshold hydraulic gradient(i0)below which no flow is observed and a critical hydraulic gradient(icr)over which the hydraulic conductivity(K)tends to be stable.The percentage of bound water could be responsible for the occurrence of i0 and icr.Furthermore,pore size distributions(PSD)less than 0.6µm and between 10 and 90µm exhibit positive and negative correlations with the i0,respectively,indicating that the i0 is related to the PSD.The mechanism accounting for this result is that pore water pressure forces fine clay particles into the surrounding large pores and converts arranged particles to discretely distributed ones,thereby weakening the connectivity of pores.The seepages in the sliding zones behave differently from that in the sliding mass and sliding bed in response to the permeability.

The mini-GWAC optical follow-up of gravitational wave alerts – results from the O2 campaign and prospects for the upcoming O3 run

The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons stars.During O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square degrees.Among them,six were finally confirmed as real astrophysical events.Since 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain astronomy.The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade.During O2,only the mini-GWAC telescope network was fully operational.Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event candidates.In this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 run.Our observations provided the largest coverage of the GW localization areas with a short latency made by any optical facility.We found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger event.Based on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers.

RET融合型非小细胞肺癌的研究进展

过去的20年来,随着分子生物学研究的不断进展,非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗方法不断发展,靶向治疗使驱动基因突变阳性患者的生存期得到了改善。越来越多的靶点逐渐被发现,针对不同驱动基因的药物将NSCLC的治疗带入了一个前景广阔的靶向时代。在NSCLC的诸多驱动基因中,转染原癌基因(transfection proto-oncogene gene,RET)融合是除了表皮生长因子受体(epidermal growth factor receptor,EGFR)、间变淋巴瘤激酶(anaplastic lymphoma kinase,ALK)及c-ros原癌基因1-受体酪氨酸激酶(c-ros oncogene 1,receptor tyrosine kinase,ROS1)以外又一个重要的新兴靶点,针对RET基因融合的靶向药物不断推陈出新,近来新型高选择性RET抑制剂BLU-667和LOXO-292获得了重要突破。本文将对NSCLC中RET基因融合突变的概述、检测方法、临床病理特征、靶向治疗及耐药后的研究进展进行综述。

Progress in the Study of Vonoprazan Fumarate vs. Proton Pump Inhibitors in the Treatment of Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disease, and proton pump inhibitors (PPIs) have been recommended as the first-line treatment for GERD. In recent years, studies on vonoprazan fumarate in the treatment of GERD have attracted widespread attention. In this paper, we review the research progress of vonoprazan fumarate and proton pump inhibitors in the treatment of GERD in recent years, and compare and analyze the efficacy, safety, tolerability, and advantages and disadvantages of long-term application of both. By reviewing the relevant literature, we found that vonoprazan fumarate has similar performance with proton pump inhibitors in terms of efficacy and safety, but has potential advantages in terms of tolerability and long-term application. Therefore, we believe that vonoprazan fumarate may become a new option for GERD treatment, helping clinicians to develop more appropriate treatment plans for patients and providing new ideas and directions for research in related fields.

不同联合手术治疗伴有和不伴有玻璃体积血的新生血管性青光眼

目的:探讨玻璃体腔注射康柏西普联合青光眼引流器植入及视网膜激光光凝对伴有和不伴有玻璃体积血的新生血管性青光眼(NVG)的疗效。方法:回顾性分析了2016/01~2017/12在西安市第一医院眼科被确诊的37例39眼伴有和不伴有玻璃体积血的NVG(虹膜房角黏连超过180°)患者的临床资料。根据是否有玻璃体积血分为两组。所有患者均接受0.5mg(0.05mL)玻璃体腔注射康柏西普。没有玻璃体积血的20例21眼(第1组)患者在玻璃体腔注射康柏西普后4d行EX-PRESS(P50)青光眼引流器植入,在青光眼引流器植入后2wk行全视网膜激光光凝。伴有玻璃体积血的17例18眼(第2组)患者在玻璃体腔注射康柏西普后4d行玻璃体切除联合EX-PRESS(P50)青光眼引流器植入及全视网膜激光光凝术,并且根据术中的实际情况选择填充空气或硅油。所有患者术后随访6mo。结果:第1组患者术前与术后6mo最佳矫正视力(BCVA)无差异(P>0.05);第2组患者术前与术后6mo BCVA有差异(P<0.05);第1组患者术后1d,1wk、1、3和6mo眼压分别为20.5±4.3mmHg,19.6±3.8mmHg,20.1±3.7mmHg,19.9±4.2mmHg和19.3±2.9mmHg。第2组患者术后1d,1wk、1、3和6mo眼压分别为22.3±3.7mmHg,20.6±2.8mmHg,20.4±3.8mmHg,18.9±4.1mmHg和19.3±3.4mmHg。第1组和第2组患者术后平均眼压均低于术前眼压(P<0.05),在随访期间3眼出现虹膜新生血管复发,故再行1次玻璃体腔注射康柏西普,治疗1wk后虹膜新生血管消退。结论:玻璃体腔注射康柏西普联合青光眼引流器植入及视网膜激光光凝能够有效降低伴有和不伴有玻璃体积血的NVG(虹膜房角黏连超过180°)患者的眼内压。

外泌体在恶性肿瘤中的研究进展

"体液活检"是近些年恶性肿瘤研究的热点,肿瘤细胞外泌体因携带其"母体"肿瘤细胞的部分功能性蛋白及基因,介导信息传递、参与调控机体的生理功能及病理状态在肿瘤的发生发展过程中起着重要作用,并作为肿瘤液态活检的一种新途径。本文旨在对外泌体的结构、生物特性和检测方法在恶性肿瘤发生发展及临床诊断治疗中的作用进行综述。

免疫检查点抑制剂在EGFR突变型晚期非小细胞肺癌中的应用

近年来,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)极大地提高了无驱动基因突变的非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的生存率。与野生型肿瘤相比,表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的肿瘤在程序性细胞死亡配体1(programmed cell death ligand 1,PD-L1)、肿瘤突变负荷(tumor mutational burden,TMB)等免疫微环境特征上具有更大的异质性。ICIs是否适用于EGFR突变的NSCLC患者一直存在争议。临床研究显示免疫单药对于EGFR突变的NSCLC患者无显著疗效,ICIs联合化疗和抗血管生成药物则显示了良好的生存获益。本文就EGFR突变晚期NSCLC患者ICIs单药或联合治疗的临床研究及相关机制进行综述。

间充质干细胞来源外泌体在恶性肿瘤中的研究进展

间充质干细胞(mesenchymal stem cells,MSCs)是存在于各种组织中的多能基质细胞。外泌体为细胞间的通讯载体,能在细胞间传递脂质、核酸以及蛋白质等生物活性分子。MSCs分泌的外泌体(mesenchymal stem cell-derived exosomes,MSC-EXO)为肿瘤微环境(tumor microenvironment,TME)的主要组成部分,并且在肿瘤的发生发展、血管生成及转移过程中发挥重要作用。本文旨在对MSCs来源的外泌体在癌症研究及其对肿瘤的作用机制予以综述,为适当利用修饰的MSC-EXO作为肿瘤治疗的策略提供新思路。