目的系统评价布地奈德联合肺表面活性物质(PS)治疗新生儿胎粪吸入综合征(MAS)的有效性与安全性。方法计算机检索PubMed、Cochrane Central Register of Controlled Trials(Central)、Embase、Web of Science、SinoMed、VIP、WanFang Dat...目的系统评价布地奈德联合肺表面活性物质(PS)治疗新生儿胎粪吸入综合征(MAS)的有效性与安全性。方法计算机检索PubMed、Cochrane Central Register of Controlled Trials(Central)、Embase、Web of Science、SinoMed、VIP、WanFang Data和CNKI数据库,搜集关于布地奈德联合PS治疗新生儿MAS的随机对照试验(RCT),检索时限均从建库至2023年9月2日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行Meta分析。结果共纳入6个RCT,包括544例患儿。Meta分析结果显示,与单用PS相比,布地奈德联合PS治疗患儿的总有效率较高[RR=1.29,95%CI(1.17,1.41),P<0.001]、住院时间较短[MD=-6.35,95%CI(-9.25,-3.46),P<0.001]、吸氧时间较短[MD=-1.61,95%CI(-2.23,-0.98),P<0.001]、呼吸机使用时间较短[MD=-26.46,95%CI(-35.98,-16.95),P<0.001],治疗后各时段患儿的血气分析指标均改善(P<0.05);布地奈德联合PS组患儿总并发症及不良反应发生率明显低于单用PS组[RR=0.35,95%CI(0.25,0.47),P<0.001]。亚组分析显示,布地奈德联合PS组患儿的持续肺动脉高压(PPHN)发生率[RR=0.38,95%CI(0.19,0.74),P=0.004]、肺出血发生率[RR=0.26,95%CI(0.10,0.69),P=0.007]均低于单用PS组;两组心力衰竭、败血症发生率差异均无统计学意义(P>0.05)。结论当前证据显示,布地奈德联合PS治疗新生儿MAS可改善患儿的症状、体征、血气分析指标,加快病情康复,缩短病程,有助于降低并发症、PPHN、肺出血的发生风险,而不会增加心力衰竭、败血症的发生风险。但受纳入研究数量的限制,上述结论尚需更多高质量、大样本的RCT予以验证。展开更多
Herein,a method of true-temperature inversion for a multi-wavelength pyrometer based on fractional-order particle-swarm optimization is proposed for difficult inversion problems with unknown emissivity.Fractional-order...Herein,a method of true-temperature inversion for a multi-wavelength pyrometer based on fractional-order particle-swarm optimization is proposed for difficult inversion problems with unknown emissivity.Fractional-order calculus has the inherent advantage of easily jumping out of local extreme values;here,it is introduced into the particle-swarm algorithm to invert the true temperature.An improved adaptive-adjustment mechanism is applied to automatically adjust the current velocity order of the particles and update their velocity and position values,increasing the accuracy of the true temperature values.The results of simulations using the proposed algorithm were compared with three algorithms using typical emissivity models:the internal penalty function algorithm,the optimization function(fmincon)algorithm,and the conventional particle-swarm optimization algorithm.The results show that the proposed algorithm has good accuracy for true-temperature inversion.Actual experimental results from a rocket-motor plume were used to demonstrate that the true-temperature inversion results of this algorithm are in good agreement with the theoretical true-temperature values.展开更多
Characterizing the trajectory of the healthy aging brain and exploring age-related structural changes in the brain can help deepen our understanding of the mechanism of brain aging.Currently,most structural magnetic r...Characterizing the trajectory of the healthy aging brain and exploring age-related structural changes in the brain can help deepen our understanding of the mechanism of brain aging.Currently,most structural magnetic resonance imaging literature explores brain aging merely from the perspective of morphological features,which cannot fully utilize the grayscale values containing important intrinsic information about brain structure.In this study,we propose the construction of two-dimensional horizontal visibility graphs based on the pixel intensity values of the gray matter slices directly.Normalized network structure entropy(NNSE)is then introduced to quantify the overall heterogeneities of these graphs.The results demonstrate a decrease in the NNSEs of gray matter with age.Compared with the middle-aged and the elderly,the larger values of the NNSE in the younger group may indicate more homogeneous network structures,smaller differences in importance between nodes and thus a more powerful ability to tolerate intrusion.In addition,the hub nodes of different adult age groups are primarily located in the precuneus,cingulate gyrus,superior temporal gyrus,inferior temporal gyrus,parahippocampal gyrus,insula,precentral gyrus and postcentral gyrus.Our study can provide a new perspective for understanding and exploring the structural mechanism of brain aging.展开更多
BACKGROUND Jackstone is a rare entity of calculi in urinary tracts and has the characteristic appearance resembling toy jacks.They are nearly always reported to occur in the urinary bladder,we first report a rare case...BACKGROUND Jackstone is a rare entity of calculi in urinary tracts and has the characteristic appearance resembling toy jacks.They are nearly always reported to occur in the urinary bladder,we first report a rare case of jackstone located in the obstructed renal calyx.CASE SUMMARY We report a 46-year-old man presenting with intermittent,painless gross hematuria and left flank pain.Urinary computed tomography revealed staghorn stones and secondary hydronephrosis.A jackstone with radiating branches was found in one of the dilated renal calyx.Percutaneous nephrolithotomy was performed and endoscopic images were recorded during the operation.Postoperative stone composition analysis revealed it as calcium oxalate monohydrate stones.CONCLUSION Jackstones can occur in the renal collecting system besides the bladder.The unique appearance and imaging manifestations are the most important factors in the diagnosis of jackstones,and further exploration of the formation mechanism is required.展开更多
目的系统评价布地奈德雾化吸入治疗新生儿胎粪吸入综合征(MAS)的疗效和安全性。方法计算机检索EMbase、PubMed、Cochrane、Wanfang Data、the ISI Web of Knowledge Databases、CBM、VIP和CNKI数据库,查找关于布地奈德雾化吸入治疗新生...目的系统评价布地奈德雾化吸入治疗新生儿胎粪吸入综合征(MAS)的疗效和安全性。方法计算机检索EMbase、PubMed、Cochrane、Wanfang Data、the ISI Web of Knowledge Databases、CBM、VIP和CNKI数据库,查找关于布地奈德雾化吸入治疗新生儿胎粪吸入综合征研究文献,检索时间均从建库至2022年5月31日。2位研究者独立进行文献筛选、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入9篇相关研究,共533例患者。Meta分析结果显示:①有效性:布地奈德组患儿住院时间、吸氧时间、呼吸窘迫缓解时间、血氧饱和度恢复时间、湿罗音消失时间、发绀消失时间明显短于对照组(P均<0.01),X线转归清晰时间与对照组差异无统计学意义;②安全性:布地奈德组患儿总并发症及不良反应发生率降低,差异有统计学意义(P<0.01)。亚组分析显示,布地奈德组患儿的呼吸窘迫综合征发生率降低,差异具有统计学意义(P<0.01);其他并发症及不良反应的发生率,包括急性肺损伤、气胸、脑膜炎、真菌感染、鹅口疮、败血症、癫痫、低血压、低血糖及高胆红素血症的发生率,与对照组差异均无统计学意义(P>0.05)。结论布地奈德雾化吸入治疗MAS可改善MAS患儿症状、体征,改善血气分析指标,加快病情康复,缩短病程,降低呼吸窘迫综合征的发生风险,且不会增加脑膜炎、败血症、真菌感染等不良反应的发生情况。展开更多
文摘目的系统评价布地奈德联合肺表面活性物质(PS)治疗新生儿胎粪吸入综合征(MAS)的有效性与安全性。方法计算机检索PubMed、Cochrane Central Register of Controlled Trials(Central)、Embase、Web of Science、SinoMed、VIP、WanFang Data和CNKI数据库,搜集关于布地奈德联合PS治疗新生儿MAS的随机对照试验(RCT),检索时限均从建库至2023年9月2日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行Meta分析。结果共纳入6个RCT,包括544例患儿。Meta分析结果显示,与单用PS相比,布地奈德联合PS治疗患儿的总有效率较高[RR=1.29,95%CI(1.17,1.41),P<0.001]、住院时间较短[MD=-6.35,95%CI(-9.25,-3.46),P<0.001]、吸氧时间较短[MD=-1.61,95%CI(-2.23,-0.98),P<0.001]、呼吸机使用时间较短[MD=-26.46,95%CI(-35.98,-16.95),P<0.001],治疗后各时段患儿的血气分析指标均改善(P<0.05);布地奈德联合PS组患儿总并发症及不良反应发生率明显低于单用PS组[RR=0.35,95%CI(0.25,0.47),P<0.001]。亚组分析显示,布地奈德联合PS组患儿的持续肺动脉高压(PPHN)发生率[RR=0.38,95%CI(0.19,0.74),P=0.004]、肺出血发生率[RR=0.26,95%CI(0.10,0.69),P=0.007]均低于单用PS组;两组心力衰竭、败血症发生率差异均无统计学意义(P>0.05)。结论当前证据显示,布地奈德联合PS治疗新生儿MAS可改善患儿的症状、体征、血气分析指标,加快病情康复,缩短病程,有助于降低并发症、PPHN、肺出血的发生风险,而不会增加心力衰竭、败血症的发生风险。但受纳入研究数量的限制,上述结论尚需更多高质量、大样本的RCT予以验证。
基金supported by the National Natural Science Foundation of China(Grant No.62205280)the Graduate Innovation Foundation of Yantai University(Grant No.GGIFYTU2348).
文摘Herein,a method of true-temperature inversion for a multi-wavelength pyrometer based on fractional-order particle-swarm optimization is proposed for difficult inversion problems with unknown emissivity.Fractional-order calculus has the inherent advantage of easily jumping out of local extreme values;here,it is introduced into the particle-swarm algorithm to invert the true temperature.An improved adaptive-adjustment mechanism is applied to automatically adjust the current velocity order of the particles and update their velocity and position values,increasing the accuracy of the true temperature values.The results of simulations using the proposed algorithm were compared with three algorithms using typical emissivity models:the internal penalty function algorithm,the optimization function(fmincon)algorithm,and the conventional particle-swarm optimization algorithm.The results show that the proposed algorithm has good accuracy for true-temperature inversion.Actual experimental results from a rocket-motor plume were used to demonstrate that the true-temperature inversion results of this algorithm are in good agreement with the theoretical true-temperature values.
基金Project supported by the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20190736)the Young Scientists Fund of the National Natural Science Foundation of China(Grant Nos.81701346 and 61603198)Qinglan Team of Universities in Jiangsu Province(Jiangsu Teacher Letter[2020]10 and Jiangsu Teacher Letter[2021]11).
文摘Characterizing the trajectory of the healthy aging brain and exploring age-related structural changes in the brain can help deepen our understanding of the mechanism of brain aging.Currently,most structural magnetic resonance imaging literature explores brain aging merely from the perspective of morphological features,which cannot fully utilize the grayscale values containing important intrinsic information about brain structure.In this study,we propose the construction of two-dimensional horizontal visibility graphs based on the pixel intensity values of the gray matter slices directly.Normalized network structure entropy(NNSE)is then introduced to quantify the overall heterogeneities of these graphs.The results demonstrate a decrease in the NNSEs of gray matter with age.Compared with the middle-aged and the elderly,the larger values of the NNSE in the younger group may indicate more homogeneous network structures,smaller differences in importance between nodes and thus a more powerful ability to tolerate intrusion.In addition,the hub nodes of different adult age groups are primarily located in the precuneus,cingulate gyrus,superior temporal gyrus,inferior temporal gyrus,parahippocampal gyrus,insula,precentral gyrus and postcentral gyrus.Our study can provide a new perspective for understanding and exploring the structural mechanism of brain aging.
文摘BACKGROUND Jackstone is a rare entity of calculi in urinary tracts and has the characteristic appearance resembling toy jacks.They are nearly always reported to occur in the urinary bladder,we first report a rare case of jackstone located in the obstructed renal calyx.CASE SUMMARY We report a 46-year-old man presenting with intermittent,painless gross hematuria and left flank pain.Urinary computed tomography revealed staghorn stones and secondary hydronephrosis.A jackstone with radiating branches was found in one of the dilated renal calyx.Percutaneous nephrolithotomy was performed and endoscopic images were recorded during the operation.Postoperative stone composition analysis revealed it as calcium oxalate monohydrate stones.CONCLUSION Jackstones can occur in the renal collecting system besides the bladder.The unique appearance and imaging manifestations are the most important factors in the diagnosis of jackstones,and further exploration of the formation mechanism is required.
文摘目的系统评价布地奈德雾化吸入治疗新生儿胎粪吸入综合征(MAS)的疗效和安全性。方法计算机检索EMbase、PubMed、Cochrane、Wanfang Data、the ISI Web of Knowledge Databases、CBM、VIP和CNKI数据库,查找关于布地奈德雾化吸入治疗新生儿胎粪吸入综合征研究文献,检索时间均从建库至2022年5月31日。2位研究者独立进行文献筛选、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入9篇相关研究,共533例患者。Meta分析结果显示:①有效性:布地奈德组患儿住院时间、吸氧时间、呼吸窘迫缓解时间、血氧饱和度恢复时间、湿罗音消失时间、发绀消失时间明显短于对照组(P均<0.01),X线转归清晰时间与对照组差异无统计学意义;②安全性:布地奈德组患儿总并发症及不良反应发生率降低,差异有统计学意义(P<0.01)。亚组分析显示,布地奈德组患儿的呼吸窘迫综合征发生率降低,差异具有统计学意义(P<0.01);其他并发症及不良反应的发生率,包括急性肺损伤、气胸、脑膜炎、真菌感染、鹅口疮、败血症、癫痫、低血压、低血糖及高胆红素血症的发生率,与对照组差异均无统计学意义(P>0.05)。结论布地奈德雾化吸入治疗MAS可改善MAS患儿症状、体征,改善血气分析指标,加快病情康复,缩短病程,降低呼吸窘迫综合征的发生风险,且不会增加脑膜炎、败血症、真菌感染等不良反应的发生情况。
