BACKGROUND： Pancreatic cancer is one of the most aggressive malignancies and chemotherapy is an effective strategy for advanced pancreatic cancer. Gemcitabine （GEM） is one of first-line agents. However, GEM-based c...BACKGROUND： Pancreatic cancer is one of the most aggressive malignancies and chemotherapy is an effective strategy for advanced pancreatic cancer. Gemcitabine （GEM） is one of first-line agents. However, GEM-based combination therapy has shown promising efficacy in patients with advanced pancreatic cancer. This meta-analysis aimed to compare the efficacy and safety of GEM-based combination therapy versus GEM alone in the treatment of advanced pancreatic cancer.DATA SOURCES： A comprehensive search of literature was performed using PubMed, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. A quantitative meta-analysis was performed based on the inclusion criteria from all eligible randomized controlled trials. The outcome indicators included overall survival （OS）, 6-month survival, 1-year survival, progression-free survival/time-to-progression （PFS/TTP）, and toxicities. RESULTS： A total of nine randomized controlled trials involving 1661 patients were included in this meta-analysis. There was significant improvement in the GEM-based combination therapy with regard to the OS （HR=0.85, 95% CI： 0.76-0.95, P=0.003）, PFS （HR=0.76, 95% CI： 0.65-0.90, P-0.002）, 6-month survival （RR=1.09, 95% CI： 1.01-1.17, P=0.03）, and the overall toxicity （RR=l.68, 95% CI： 1.52-1.86, P〈0.01）. However, there was no significant difference in the 1-year survival.CONCLUSIONS： GEM-based combination chemotherapy might improve the OS, 6-month survival, and PFS in advanced pancreatic cancer. However, combined therapy also added toxicity.展开更多
Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes ametho...Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes amethod developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and fabricated.After evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally analyzed.Furthermore,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel connectivity.Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.Furthermore,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paperbased microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.展开更多
BACKGROUND Primary intraspinal malignant melanoma is a very rare tumor that most often occurs in the cervical,thoracic,or thoracolumbar segment.CASE SUMMARY A rare case of primary thoracolumbar malignant melanoma is d...BACKGROUND Primary intraspinal malignant melanoma is a very rare tumor that most often occurs in the cervical,thoracic,or thoracolumbar segment.CASE SUMMARY A rare case of primary thoracolumbar malignant melanoma is described.A 45-year-old female patient complained of low back pain with numbness and fatigue in both lower limbs.MR revealed an intradural space-occupying lesion at the thoracic 12 to lumbar 1 level.The tumor was partially excised,and a malignant melanoma was confirmed by histopathology.CONCLUSION Primary intraspinal malignant melanoma has rarely been reported,and surgical resection and related characteristics and diagnoses have been discussed.展开更多
The matching and retrieval of the 2D shapes are challenging issues in object recognition and computer vision. In this paper, we propose a new object contour descriptor termed ECPDH (Elliptic Contour Points Distributio...The matching and retrieval of the 2D shapes are challenging issues in object recognition and computer vision. In this paper, we propose a new object contour descriptor termed ECPDH (Elliptic Contour Points Distribution Histogram), which is based on the distribution of the points on an object contour under the polar coordinates. ECPDH has the essential merits of invariance to scale and translation. Dynamic Programming (DP) algorithm is used to measure the distance between the ECPDHs. The effectiveness of the proposed method is demonstrated using some standard tests on MPEG-7 shape database. The results show the precision and recall of our method over other recent methods in the literature.展开更多
A facile one-step method was developed for the fabrication of hierarchical ZnO film on substrate. Neither seed nor catalyst layer is necessary for the growth of hierarchical ZnO film. Three kinds of nucleation process...A facile one-step method was developed for the fabrication of hierarchical ZnO film on substrate. Neither seed nor catalyst layer is necessary for the growth of hierarchical ZnO film. Three kinds of nucleation process were found, and the influences of growth time, growth electrolyte, growth temperature on the morphology of ZnO film were evaluated. Hierarchical ZnO film can absorb more than 97% of incident photons with wavelength shorter than 380 nm. Such hierarchical ZnO film would be a promising scaffold for photoelectrochemical application.展开更多
基金supported by grants from the Scientific Research Foundation of Traditional Chinese Medicine of Zhejiang Province(2015ZA081)Zhejiang Provincial Natural Science Foundation of China(LY14H030006)+1 种基金Foundation for Young Scientists of Zhejiang Province Traditional Chinese Medicine(2011ZQ008)the Health and Family Planning Committee of Zhejiang Province(2012KYB143)
文摘BACKGROUND： Pancreatic cancer is one of the most aggressive malignancies and chemotherapy is an effective strategy for advanced pancreatic cancer. Gemcitabine （GEM） is one of first-line agents. However, GEM-based combination therapy has shown promising efficacy in patients with advanced pancreatic cancer. This meta-analysis aimed to compare the efficacy and safety of GEM-based combination therapy versus GEM alone in the treatment of advanced pancreatic cancer.DATA SOURCES： A comprehensive search of literature was performed using PubMed, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. A quantitative meta-analysis was performed based on the inclusion criteria from all eligible randomized controlled trials. The outcome indicators included overall survival （OS）, 6-month survival, 1-year survival, progression-free survival/time-to-progression （PFS/TTP）, and toxicities. RESULTS： A total of nine randomized controlled trials involving 1661 patients were included in this meta-analysis. There was significant improvement in the GEM-based combination therapy with regard to the OS （HR=0.85, 95% CI： 0.76-0.95, P=0.003）, PFS （HR=0.76, 95% CI： 0.65-0.90, P-0.002）, 6-month survival （RR=1.09, 95% CI： 1.01-1.17, P=0.03）, and the overall toxicity （RR=l.68, 95% CI： 1.52-1.86, P〈0.01）. However, there was no significant difference in the 1-year survival.CONCLUSIONS： GEM-based combination chemotherapy might improve the OS, 6-month survival, and PFS in advanced pancreatic cancer. However, combined therapy also added toxicity.
基金sponsored by the National Natural Science Foundation of China(No.52235007,YH)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004,YH)+3 种基金the NationalNatural Science Foundation of China(No.52305300,MJX)the Fellowship of China Postdoctoral Science Foundation(No.2022M722826,MJX)the National Natural Science Foundation of China(No.82203602,JW)the Zhejiang Provincial Natural Science Foundation of China(No.LQ22H160020,JW)。
文摘Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes amethod developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and fabricated.After evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally analyzed.Furthermore,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel connectivity.Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.Furthermore,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paperbased microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.
文摘BACKGROUND Primary intraspinal malignant melanoma is a very rare tumor that most often occurs in the cervical,thoracic,or thoracolumbar segment.CASE SUMMARY A rare case of primary thoracolumbar malignant melanoma is described.A 45-year-old female patient complained of low back pain with numbness and fatigue in both lower limbs.MR revealed an intradural space-occupying lesion at the thoracic 12 to lumbar 1 level.The tumor was partially excised,and a malignant melanoma was confirmed by histopathology.CONCLUSION Primary intraspinal malignant melanoma has rarely been reported,and surgical resection and related characteristics and diagnoses have been discussed.
文摘The matching and retrieval of the 2D shapes are challenging issues in object recognition and computer vision. In this paper, we propose a new object contour descriptor termed ECPDH (Elliptic Contour Points Distribution Histogram), which is based on the distribution of the points on an object contour under the polar coordinates. ECPDH has the essential merits of invariance to scale and translation. Dynamic Programming (DP) algorithm is used to measure the distance between the ECPDHs. The effectiveness of the proposed method is demonstrated using some standard tests on MPEG-7 shape database. The results show the precision and recall of our method over other recent methods in the literature.
文摘A facile one-step method was developed for the fabrication of hierarchical ZnO film on substrate. Neither seed nor catalyst layer is necessary for the growth of hierarchical ZnO film. Three kinds of nucleation process were found, and the influences of growth time, growth electrolyte, growth temperature on the morphology of ZnO film were evaluated. Hierarchical ZnO film can absorb more than 97% of incident photons with wavelength shorter than 380 nm. Such hierarchical ZnO film would be a promising scaffold for photoelectrochemical application.
