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厄贝沙坦对链脲佐菌素和过氧化氢诱导的β细胞氧化损伤保护作用 被引量:1
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作者 莫香来 卢佩珮 +5 位作者 雷相国 Tamrakar Rashi 张劼 尹健兰 杨曦 梁杏欢 《蛇志》 2023年第1期26-32,共7页
目的 探讨厄贝沙坦对链脲佐菌素(STZ)和过氧化氢(H_(2)O_(2))诱导的β细胞损伤影响。方法 (1)将NIT-1细胞分为对照组及1、2、5 mmol/L STZ和300、500μmol/L H_(2)O_(2)组,处理30 min后,采用Hoechst 33342法检测各组细胞凋亡形态变化,... 目的 探讨厄贝沙坦对链脲佐菌素(STZ)和过氧化氢(H_(2)O_(2))诱导的β细胞损伤影响。方法 (1)将NIT-1细胞分为对照组及1、2、5 mmol/L STZ和300、500μmol/L H_(2)O_(2)组,处理30 min后,采用Hoechst 33342法检测各组细胞凋亡形态变化,流式细胞术检测细胞凋亡率,RT-qPCR检测Caspase3 mRNA水平。(2)将NIT-1细胞分为STZ及0.001、0.01、0.1 mmol/L厄贝沙坦组,作用24、48和72 h。(3)将NIT-1细胞分为H_(2)O_(2)及0.001、0.01、0.1 mmol/L厄贝沙坦组,作用24、48和72 h。采用流式细胞术检测细胞凋亡率和活性氧(ROS)含量,RT-qPCR检测血管紧张素II型1受体(AT1R)mRNA表达。结果 Hoechst 33342染色显示,5 mmol/L STZ组相较于1、2 mmol/L STZ组,500μmol/L H_(2)O_(2)组相较于300μmol/L H_(2)O_(2)组的细胞荧光染色较强,细胞碎片较多。5 mmol/L STZ组凋亡率为70.42%高于1、2 mmol/L STZ组的凋亡率(8.75%、47.2%)(均P<0.05)。500μmol/L H_(2)O_(2)组凋亡率为70.45%高于300μmol/L H_(2)O_(2)组的58.13%(P<0.05)。2 mmol/L STZ和300μmol/L H_(2)O_(2)诱导的NIT-1细胞中Caspase3 mRNA表达分别上调2.63、6.25倍(均P<0.05)。在STZ和H_(2)O_(2)模型组中,0.001、0.01、0.1 mmol/L厄贝沙坦组的细胞凋亡率、ROS水平和AT1R mRNA相对表达量均低于STZ组或H_(2)O_(2)组,差异均有统计学意义(均P<0.05)。同一浓度厄贝沙坦组中,72 h的细胞凋亡率和ROS水平均低于48 h和24 h,差异均有统计学意义(均P<0.05)。结论 2 mmol/L STZ和300μmol/L H_(2)O_(2)是诱导NIT-1细胞氧化急性损伤的适宜条件。厄贝沙坦可能通过抑制ROS生成和降低凋亡率来保护β细胞免受STZ和H_(2)O_(2)诱导的氧化损伤,其分子机制可能与AT1R mRNA水平的降低有关。厄贝沙坦有潜力成为预防和治疗2型糖尿病的新型药物。 展开更多
关键词 厄贝沙坦 氧化损伤 凋亡 Β细胞
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Measured and Simulated Performance of a Four-Segmented Clover Detector
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作者 ZHANG Ning-Tao lei xiang-guo +11 位作者 ZHANG Yu-Hu ZHOU Xiao-Hong LIU Min-Liang GUO Ying-Xiang FANG Yong-De LI Shi-Cheng ZHOU Hou-Bing DING Bing WANG Hai-Xia WU Xiao-Guang HE Chuang-Ye ZHENG Yun 《Chinese Physics Letters》 SCIE CAS CSCD 2012年第4期51-53,共3页
Gamma rays with energies between 80keV and 1500keV produced by 133Ba and 152Eu standard sources are measured with the clover detector.Relative efficiencies and add-back factors are determined in both crystals and full... Gamma rays with energies between 80keV and 1500keV produced by 133Ba and 152Eu standard sources are measured with the clover detector.Relative efficiencies and add-back factors are determined in both crystals and full clover modes.The add-back characteristics have been calculated using Monte-Carlo simulation code Geant4.The simulation and measurements agree very well. 展开更多
关键词 DETECTOR KEV GEANT4
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Experimental Study on High-Spin States in ^(119)Xe
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作者 HUANG Wen-xue GUO Ying-Xiang +14 位作者 SUN Xiang-Fu lei xiang-guo ZHOU Xiao-Hong LIU Zhong ZHANG Yu-Hu ZHU Shao-Fei XU Xiac FENG Xi-Chen LIUMing-Yi LUO Yi-Xiao WEN Shu-Xian WU xiao-Guang YUAN Guan-Jun LI Guang-Sheng YANG Chun-Xiang 《Chinese Physics Letters》 SCIE CAS CSCD 2000年第7期483-484,共2页
High-spin states of^(119)Xe have been investigated by in-beam γ-ray spectroscopy via the reaction of ^(16)O bombarding a ^(106)Cd target at beam energies of 67-80MeV. No enhanced E1 transition was observed, the non-e... High-spin states of^(119)Xe have been investigated by in-beam γ-ray spectroscopy via the reaction of ^(16)O bombarding a ^(106)Cd target at beam energies of 67-80MeV. No enhanced E1 transition was observed, the non-existence of octupole correlations in ^(119) Xe. 展开更多
关键词 BEAM TRANSITION
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Half-Lives of Low-Lying Isomeric States in ^(169)Ta
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作者 ZHANG Yu-hu ZHAO Qing-zhong +11 位作者 ZHU Shao-fei XU Hu-shan ZHOU Xiao-hong GUO Ying-xiang lei xiang-guo LU Jun GOU Quan-bu LIU Zhong JIN Han-juan LUO Yi-xiao SUN Xiang-fu ZHU Yong-tai 《Chinese Physics Letters》 SCIE CAS CSCD 1998年第2期92-94,共3页
Two low-lying isomeric states in 169Ta have been identified via ^(159)Tb(l6O,6nγ)^(169)Ta reaction.Their half-lives are measured to be 28±5ns for the 9/2^(-)level and 17±4 ns for the 5/2^(-)level by using t... Two low-lying isomeric states in 169Ta have been identified via ^(159)Tb(l6O,6nγ)^(169)Ta reaction.Their half-lives are measured to be 28±5ns for the 9/2^(-)level and 17±4 ns for the 5/2^(-)level by using the delayedγ-γcoincidence method.These two isomeric states are considered to be the bandheads with 9/2-[514]and 1/2-[541]configurations,respectively.Possible neutron quasiparticle configuration for the ground state of ^(169)W is discussed. 展开更多
关键词 reaction. method.
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Signature Inversion of Yrast Band in Odd-Odd ^(162)Lu Nucleus
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作者 ZHANG Yu-hu ZHOU Xiao-hong +9 位作者 ZHAO Qing-zhong SUN Xiang-fu lei xiang-guo GUO Ying-xiang LIU Zhong CHEN Xing-feng ZHU Yong-tai WEN Shu-xian YUAN Guan-jun LIU Xiang-an 《Chinese Physics Letters》 SCIE CAS CSCD 1996年第4期257-260,共3页
High spin states of the odd-odd ^(162)Lu nucleus have been studied via ^(147)Sm(^(19)F,4nγ)reaction at 95MeV beam energy.Level scheme for yrast band based on π[h_(11/2)]v[i_(13/2)]quasiparticle configuration was est... High spin states of the odd-odd ^(162)Lu nucleus have been studied via ^(147)Sm(^(19)F,4nγ)reaction at 95MeV beam energy.Level scheme for yrast band based on π[h_(11/2)]v[i_(13/2)]quasiparticle configuration was established up to I^(π)-(23^(-))for the first time.This band shows the signature inversion in energy before backbending generally appeared in this mass region.It is stressed that the signature splitting in 162Lu is larger than that in 160 Tm nucleus. 展开更多
关键词 energy SIGNATURE
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New Isomeric States in ^(197)Bi
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作者 ZHOU Xiao-hong SUN Xiang-fu +10 位作者 GUO Ying-xiang lei xiang-guo CHEN Xin-feng LIU Zhong ZHANG Yu-hu JIN Han-juan LUO Yi-xiao WEN Shu-xian YUAN Guan-jun LI Guang-sheng YANG Chun-xiang 《Chinese Physics Letters》 SCIE CAS CSCD 1996年第1期13-16,共4页
The high-spin states in ^(197)Bi have been studied with the ^(187)Re(^(16)O,6n)reaction at ^(16)O energies from 85 to 105MeV.In-beam measurements of γ-ray excitation functions,γ-γ-t coincidences and γ-ray angular ... The high-spin states in ^(197)Bi have been studied with the ^(187)Re(^(16)O,6n)reaction at ^(16)O energies from 85 to 105MeV.In-beam measurements of γ-ray excitation functions,γ-γ-t coincidences and γ-ray angular distributions were carried out with six BGO(AC)HPGe detectors and one intrinsic Ge planar detector.Eleven new tram sitions and three new isomers were observed,and a level scheme for ^(197)Bi was established.Some differences between the present work and the previous results were found. 展开更多
关键词 DETECTOR ISOMERS
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Evidence for Octupole Correlations in ^(117)Xe
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作者 LIU Zhong SUN Xiang-fu +12 位作者 ZHOU Xiao-hong lei xiang-guo GUO Ying-xiang JIN Han-juan ZHANG Yu-hu CHEN Xin-feng LUO Yi-xiao WEN Shu-xian YANG Chun-xiang YUAN Guan-jun LI Guang-sheng LIU Xiang-an Chen Yong-shou 《Chinese Physics Letters》 SCIE CAS CSCD 1996年第11期805-808,共4页
High spin states in neutron-deficient ^(117)Xe have been studied by using in-beamγspectroscopy method.A new positive-parity rotational band has been identified.It decays into the yrast vh_(11/2 )band via five electri... High spin states in neutron-deficient ^(117)Xe have been studied by using in-beamγspectroscopy method.A new positive-parity rotational band has been identified.It decays into the yrast vh_(11/2 )band via five electric dipole transitions.The magnitudes of these E1 transitions are extracted and they are much enhanced compared to the normal E1 transitions.This is taken as an evidence for octupole correlations in ^(117)Xe. 展开更多
关键词 METHOD TRANSITIONS
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A High-Spin Isomer in ^(198)Bi
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作者 ZHOU Xiao-hong SUN Xiang-fu +10 位作者 GUO Ying-xiang lei xiang-guo CHEN Xin-feng LIU Zhong ZHANG Yu-hu JIN Han-juan LUO Yi-xiao WEN Shu-xian YUAN Guan-jun LI Guang-sheng YANG Chun-xiang 《Chinese Physics Letters》 SCIE CAS CSCD 1996年第8期576-578,共3页
High-spin states in ^(198)Bi were populated via the ^(187)Re(^(16)O,5n)reaction.A partial level scheme for ^(198)Bi was established for the first time,including a 15^(+)high-spin isomeric state with a measured half-li... High-spin states in ^(198)Bi were populated via the ^(187)Re(^(16)O,5n)reaction.A partial level scheme for ^(198)Bi was established for the first time,including a 15^(+)high-spin isomeric state with a measured half-life of 8.0±3.6ns.By comparing the level structure of ^(198)Bi with that of the even-even core ^(198)Pb,the configuration v(i_(13/2))^(-2) v(P_(3/2))^(-1)π(h_(9/2))^(1) was ascribed to this isomeric state. 展开更多
关键词 REACTION STATE
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Semidecoupled Band and Shape Driving Effect of the π1/2^(-)[541] Orbital in ^(170)Ta
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作者 ZHANG Yu-hu ZHAO Qing-zhong +11 位作者 ZHOU Xiao-hong XU Hu-shan GUO Ying-iang lei xiang-guo LU Jun ZHU Shao-fei GOU Quan-bu JIN Han-juan LIU Zhong LUO Yi-xiao SUN Xiang-fu ZHU Yong-tai 《Chinese Physics Letters》 SCIE CAS CSCD 1997年第6期409-412,共4页
High spin states in ^(170)Ta have been studied via ^(159)Tb(^(16)O,5nγ)^(170)Ta reaction at 105MeV beam energy.Three rotational bands have been observed among which one coupled band and an unfavoredΔI=2 transition s... High spin states in ^(170)Ta have been studied via ^(159)Tb(^(16)O,5nγ)^(170)Ta reaction at 105MeV beam energy.Three rotational bands have been observed among which one coupled band and an unfavoredΔI=2 transition sequence of the semidecoupled band are identified in this work.The effects of theπ1/2^(-)[541]proton intruder orbital are qualitatively discussed. 展开更多
关键词 energy.
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Excited States in Neutron-Deficient ^(197)Bi
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作者 Zhou Xiao-hong Sun Xian-fu +7 位作者 Guo Yin-xiang lei xiang-guo Chen Xin-feng Liu Zhong Jin Han-juan and Luo Yi-xiao, Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 73000Wen Shu-xian Yuan Guan-jun Li Guang-sheng Yang Chong-xiang, China Institute of Atomic Energy, Beijing 102413 《Chinese journal of nuclear physics》 1995年第4期328-335,共8页
The high-spin states in <sup>197</sup>Bi are studied with the <sup>197</sup>Re(<sup>16</sup>O, 6n) reaction, theenergies of <sup>16</sup>O being between 85 and 105 MeV. ... The high-spin states in <sup>197</sup>Bi are studied with the <sup>197</sup>Re(<sup>16</sup>O, 6n) reaction, theenergies of <sup>16</sup>O being between 85 and 105 MeV. In-beam measurements of γ-ray excitation func-tions, γ-γ-t coincidences and γ-ray angular distributions are performed with six BGO (AC)HPGe detectors and one intrinsic Ge planar detector. Eleven new transitions and three new iso-mers at 2089, 2357 and 1968+△keV with T<sub>1/2</sub>=19, 34±4, 9, 53, 4±20. 5 and 18. 04±3. 1 ns,respectively, are observed, and a level scheme established. In addition, a half-life of 36. 7±7.0 ns was determined for the first time for the previously established 2065 keV isomer. 展开更多
关键词 ISOMER Level SCHEME γ-γ-l COINCIDENCE
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Properties of theβDelayed Proton Decay of 147Er
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作者 MA Fei ZHOU Xiao-Hong +13 位作者 ZHENG Yong XU Shu-Wei XIE Yuan-Xiang CHEN Liang ZHANG Yu-Hu LI Zhan-Kui QIANG Yun-Hua lei xiang-guo GUO Ying-Xiang GUO Song DING Bing WANG Hai-Xia LI Guang-Shun ZHOU Hou-Bing 《Chinese Physics Letters》 SCIE CAS CSCD 2010年第6期59-61,共3页
The β-delayed proton decay of 147Er is studied experimentally using the 58 Ni+92Mo reaction at a beam energy of 383 MeV. Based on a He-jet apparatus coupled with a tape transport system, the β-delayed proton radioa... The β-delayed proton decay of 147Er is studied experimentally using the 58 Ni+92Mo reaction at a beam energy of 383 MeV. Based on a He-jet apparatus coupled with a tape transport system, the β-delayed proton radioactivities both from the vδl/2 ground state and the vh11/2 isomer in 147 Er are identified by proton-7 coincidence measurements. By analyzing the time distribution of the 4+ → 2+-γ transition in the grand-daughter nucleus 146Dy, a half-life of 1.6 ± 0.2s is determined for the Vh11/2 isomer in 147 Er. The half-life for the ground state of 147Er is estimated to be 3.2±1.2 s. 展开更多
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