For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein th...For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein thrombosis.Surgery is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury patients.Development of effective therapies fo r chronic spinal co rd injury patients is needed.We conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive rehabilitation.This clinical trial was registered at ClinicalTrials.gov(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord compression.We found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training alone.Overall,the surgical procedures and intensive rehabilitation were safe.American Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 injuries.Surgery combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.展开更多
The alpine meadow ecosystem accounts for 27%of the total area of the Tibetan Plateau and is also one of the most important vegetation types.The Dangxiong alpine meadow ecosystem,located in the south-central part of th...The alpine meadow ecosystem accounts for 27%of the total area of the Tibetan Plateau and is also one of the most important vegetation types.The Dangxiong alpine meadow ecosystem,located in the south-central part of the Tibetan Plateau,is a typical example.To understand the carbon and water fluxes,water use efficiency(WUE),and their responses to future climate change for the alpine meadow ecosystem in the Dangxiong area,two parameter estimation methods,the Model-independent Parameter Estimation(PEST)and the Dynamic Dimensions Search(DDS),were used to optimize the Biome-BGC model.Then,the gross primary productivity(GPP)and evapotranspiration(ET)were simulated.The results show that the DDS parameter calibration method has a better performance.The annual GPP and ET show an increasing trend,while the WUE shows a decreasing trend.Meanwhile,ET and GPP reach their peaks in July and August,respectively,and WUE shows a“dual-peak”pattern,reaching peaks in May and November.Furthermore,according to the simulation results for the next nearly 100 years,the ensemble average GPP and ET exhibit a significant increasing trend,and the growth rate under the SSP5–8.5 scenario is greater than that under the SSP2–4.5 scenario.WUE shows an increasing trend under the SSP2–4.5 scenario and a significant increasing trend under the SSP5–8.5 scenario.This study has important scientific significance for carbon and water cycle prediction and vegetation ecological protection on the Tibetan Plateau.展开更多
With the rapid development of artificial intelligence and the widespread use of the Internet of Things, semantic communication, as an emerging communication paradigm, has been attracting great interest. Taking image t...With the rapid development of artificial intelligence and the widespread use of the Internet of Things, semantic communication, as an emerging communication paradigm, has been attracting great interest. Taking image transmission as an example, from the semantic communication's view, not all pixels in the images are equally important for certain receivers. The existing semantic communication systems directly perform semantic encoding and decoding on the whole image, in which the region of interest cannot be identified. In this paper, we propose a novel semantic communication system for image transmission that can distinguish between Regions Of Interest (ROI) and Regions Of Non-Interest (RONI) based on semantic segmentation, where a semantic segmentation algorithm is used to classify each pixel of the image and distinguish ROI and RONI. The system also enables high-quality transmission of ROI with lower communication overheads by transmissions through different semantic communication networks with different bandwidth requirements. An improved metric θPSNR is proposed to evaluate the transmission accuracy of the novel semantic transmission network. Experimental results show that our proposed system achieves a significant performance improvement compared with existing approaches, namely, existing semantic communication approaches and the conventional approach without semantics.展开更多
Evapotranspiration(ET)is a crucial variable in the terrestrial water,carbon,and energy cycles.At present,a large number of multi source ET products exist.Due to sparse observations,however,great challenges exist in th...Evapotranspiration(ET)is a crucial variable in the terrestrial water,carbon,and energy cycles.At present,a large number of multi source ET products exist.Due to sparse observations,however,great challenges exist in the evaluation and integration of ET products in remote and complex areas such as the Tibetan Plateau(TP).In this paper,the applicability of the multiple collocation(MC)method over the TP is evaluated for the first time,and the uncertainty of multisource ET products(based on reanalysis,remote sensing,and land surface models)is further analyzed,which provides a theoretical basis for ET data fusion.The results show that 1)ET uncertainties quantified via the MC method are lower in RS-based ET products(5.95 vs.7.06 mm month^(-1))than in LSM ET products(10.22 vs.17.97 mm month^(-1))and reanalysis ET estimates(7.27 vs.12.26 mm month-1).2)A multisource evapotranspiration(MET)dataset is generated at a monthly temporal scale with a spatial resolution of 0.25°across the TP during 2005-15.MET has better performance than any individual product.3)Based on the fusion product,the total ET amount over the TP and its patterns of spatiotemporal variability are clearly identified.The annual total ET over the entire TP is approximately 380.60 mm.Additionally,an increasing trend of 1.59±0.85 mm yr^(-1)over the TP is shown during 2005-15.This study provides a basis for future studies on water and energy cycles and water resource management over the TP and surrounding regions.展开更多
A combined experimental and numerical research study is conducted to investigate the complex relationship between the structure and the aerodynamic performances of an Archimedes spiral wind turbine(ASWT).Two ASWTs are...A combined experimental and numerical research study is conducted to investigate the complex relationship between the structure and the aerodynamic performances of an Archimedes spiral wind turbine(ASWT).Two ASWTs are considered,a prototypical version and an improved version.It is shown that the latter achieves the best aerodynamic performance when the spread angles at the three sets of blades areα_(1)=30°,α_(2)=55°,α3=60°,respectively and the blade thickness is 4 mm.For a velocity V=10 m/s,a tip speed ratio(TSR)=1.58 and 2,the maximum CP values are 0.223 and 0.263 for the prototypical ASWT and improved ASWT,respectively,and the maximum C_(P) enhancement is 17.93%.For V=10 m/s and TSR=2,the CP values of the prototypical ASWT and improved ASWT are 0.225 and 0.263,respectively,with an aerodynamic performance enhancement of 16.88%.Through mutual verification of the test outcomes and numerical results,it is concluded that the proposed approach can effectively lead to aerodynamic performance improvement.展开更多
Soy protein isolate(SPI)is a commercial protein with balanced amino acids,while the poor solubility impedes its use in traditional foods.To overcome the problem,the complex coacervation of SPI/Flammulina velutipes pol...Soy protein isolate(SPI)is a commercial protein with balanced amino acids,while the poor solubility impedes its use in traditional foods.To overcome the problem,the complex coacervation of SPI/Flammulina velutipes polysaccharide(FVP)were investigated.Initial results revealed that the suitable amounts of FVP contributed to reducing the turbidity of SPI solution.Under electrostatic interaction,the formation of SPI/FVP coacervates were spontaneous and went through a nucleation and growth process.Low salt concentration(C_(NaCl)=10,50 mmol/L)led to an increase in the critical pH values(pHc,pHφ1)while the critical pH values decreased when C_(NaCl)≥100 mmol/L.The concentration of NaCl ions increased the content ofα-helix.With the increase of FVP,the critical pH values decreased and the content ofβ-sheet increased through electrostatic interaction.At SPI/FVP ratio of 10:1 and 15:1,the complex coacervation of SPI/FVP were saturated,and the coacervates had the same storage modulus value.SPI/FVP coacervates exhibited solid-like properties and presented the strongest storage modulus at C_(NaCl)=50 mmol/L.The optimal pH,SPI/FVP ratio and NaCl concentration of complex coacervation were collected,and the coacervates demonstrated a valuable application potential to protect and deliver bioactives and food ingredients.展开更多
Amorphous carbons are promising anodes for high-rate potassium-ion batteries.Most low-temperature annealed amorphous carbons display unsatisfactory capacities.Heteroatom-induced defect engineering of amorphous carbons...Amorphous carbons are promising anodes for high-rate potassium-ion batteries.Most low-temperature annealed amorphous carbons display unsatisfactory capacities.Heteroatom-induced defect engineering of amorphous carbons could enhance their reversible capacities.Nevertheless,most lignocellulose biomasses lack heteroatoms,making it a challenge to design highly heteroatom-doped carbons(>10 at%).Herein,we report a new preparation strategy for amorphous carbon anodes.Nitrogen/sulfur co-doped lignin-derived porous carbons(NSLPC)with ultra-high nitrogen doping levels(21.6 at%of N and 0.8 at%of S)from renewable lignin biomacromolecule precursors were prepared through a supramolecule-mediated pyrolysis strategy.This supermolecule/lignin composite decomposes forming a covalently bonded graphitic carbon/amorphous carbon intermediate product,which induces the formation of high heteroatom doping in the obtained NSLPC.This unique pyrolysis chemistry and high heteroatom doping of NSLPC enable abundant defective active sites for the adsorption of K+and improved kinetics.The NSLPC anode delivered a high reversible capacity of 419 mAh g^(-1)and superior cycling stability(capacity retention of 96.6%at 1 A g^(-1)for 1000 cycles).Potassiumion hybrid capacitors assembled by NSLPC anode exhibited excellent cycling stability(91%capacity retention for 2000 cycles)and a high energy density of 71 Wh kg^(-1)at a power density of 92 W kg^(-1).展开更多
Flammulina velutipes(F.velutipes)polysaccharides were modified by ultrasound at the rated power of 150 W and 900 W.The monosaccharide composition,ultraviolet-visible,and Fourier transform infrared spectral characteris...Flammulina velutipes(F.velutipes)polysaccharides were modified by ultrasound at the rated power of 150 W and 900 W.The monosaccharide composition,ultraviolet-visible,and Fourier transform infrared spectral characteristics of F.velutipes polysaccharides(FVP)and their ultrasonic modification products(U-FVPs)were determined.The protective effects of FVP and U-FVPs on human gastric mucosal cells GES-1 were confi rmed for the first time.The mole ratios of glucose and galactose were decreased and the mole ratio of mannose was increased after ultrasonic modification.Compared with the original FVP and the FVP modifi ed by ultrasound of 150 W(U-FVP1),the FVP modifi ed by ultrasound of 900 W(U-FVP2)could better prevent ethanol-induced damage to GES-1 cells.With increasing ultrasound intensity,the protective effect of FVPs on GES-1 cells was significantly enhanced by more effective prevention of intracellular reactive oxygen species(ROS)production and more promotion of expression of triglyceride factor 2(TFF2),prostaglandin E2(PGE2),epidermal growth factor(EGF),and transforming growth factorβ1(TGF-β1)mRNA.The ultrasonic modifi cation might be an effective way to develop novel F.velutipes polysaccharides that could effectively resist the gastric injury caused by excessive alcohol consumption.展开更多
AIM:To describe the subcutaneous pedicled propeller flap technique for the microscopic reconstruction of eyelid defects and evaluate its outcomes.METHODS:The clinical data of 23 patients(23 eyes)who underwent microsco...AIM:To describe the subcutaneous pedicled propeller flap technique for the microscopic reconstruction of eyelid defects and evaluate its outcomes.METHODS:The clinical data of 23 patients(23 eyes)who underwent microscopic reconstruction of eyelid defects with the subcutaneous pedicled propeller flap technique were retrospectively analyzed.All patients underwent eyelid tumor resection and one-stage microscopic reconstruction with the subcutaneous pedicled propeller flap for anterioror posterior-layer eyelid defects.The survival rate of the propeller flap,eyelid function and appearance,tumor recurrence rate,and patient satisfaction were evaluated after the surgery.RESULTS:The patients consisted of 12 men and 11 women,aged 31–82y(mean,58.9y).The longest followup time was 5y,and the shortest was 3mo.All the propeller flaps survived well.There was no significant difference in color and luster between the flap and adjacent tissues,and there was no dog ear phenomenon.No obvious scarring was observed.There were no obvious abnormalities of eyelid morphology or function,and no adverse complications such as exposure keratitis,entropion,ectropion,ptosis,and eyelid retraction.No tumor recurrence was found at the time of the last follow-up.All patients were satisfied with the surgical results.CONCLUSION:The subcutaneous pedicled propeller flap technique for the microscopic reconstruction of eyelid defects has satisfactor y outcomes in terms of eyelid function and esthetics,and merits clinical application.展开更多
AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1...AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral hypersensitivity.in normal rats and 4.5 ± 1.58 in IBS model rats(P < 0.001). However, the defecation frequency was significantly decreased(3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time(in seconds) of colon transit function was significantly increased(256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.展开更多
The non-hydrostatic global variable resolution model(MPAS-atmosphere)is used to conduct the simulations for the South Asian Summer monsoon season(June,July,and August)in 2015 with a refinement over the Tibetan Plateau...The non-hydrostatic global variable resolution model(MPAS-atmosphere)is used to conduct the simulations for the South Asian Summer monsoon season(June,July,and August)in 2015 with a refinement over the Tibetan Plateau(TP)at the convection-permitting scale(4 km).Two experiments with different topographical datasets,complex(4-km)and smooth(60-km)topography,are designed to investigate the impacts of topographical complexity on moisture transport and precipitation.Compared with the observations and reanalysis data,the simulation can successfully capture the general features of key meteorological fields over the TP despite slightly underestimating the inflow through the southern TP.The results indicate that the complex topography can decrease the inward and outward moisture transport,ultimately increasing the total net moisture transport into the TP by~11%.The impacts of complex topography on precipitation are negligible over the TP,but the spatial distributions of precipitation over the Himalayas are significantly modulated.With the inclusion of complex topography,the sharper southern slopes of the Himalayas shift the lifted airflow and hence precipitation northward compared to the smooth topography.In addition,more small-scale valleys are resolved by the inclusion of complex topography,which serve as channels for moisture transport across the Himalayas,further favoring a northward shift of precipitation.Overall,the difference between the two experiments with different topography datasets is mainly attributed to their differing representation of the degree of the southern slopes of the Himalayas and the extent to which the valleys are resolved.展开更多
AIMTo expose rat retinal Müller cells to 530 nm monochromatic light and investigate the influence of varying light illumination times on basic fibroblast growth factor (bFGF) and transforming growth factor...AIMTo expose rat retinal Müller cells to 530 nm monochromatic light and investigate the influence of varying light illumination times on basic fibroblast growth factor (bFGF) and transforming growth factor-β1 (TGF-β1) expression.METHODSThree groups of rat retinal Müller cells cultured in vitro under a 530 nm monochromatic light were divided into 6, 12 and 24h experimental groups, while cells incubated under dark conditions served as the control group. The bFGF and TGF-β1 mRNA expression, protein levels and fluorescence intensity of the Müller cells were analyzed.RESULTSThe bFGF mRNA expression and protein levels were significantly upregulated in Müller cells in all three experimental groups compared with the control group (P<0.05), while that of TGF-β1 was downregulated (P<0.05). Also, bFGF expression was positively correlated, but TGF-β1 expression was negatively correlated with illumination time. The largest changes for both cytokines were seen in the 24h group. The changes in bFGF and TGF-β1 fluorescence intensity were highest in the 24h group, and significant differences were observed among the experimental groups (P<0.05).CONCLUSIONThe expressions of bFGF and TGF-β1 changed in a time-dependent manner in Müller cells exposed to 530 nm monochromatic light with 250 lx illumination intensity. Müller cells might play a role in the development of myopia by increasing bFGF expression or decreasing TGF-β1 expression. Changes in cytokine expression in retinal Müller cells may affect monochromatic light-induced myopia.展开更多
Neoadjuvant chemoradiotherapy(nCRT)and total rectal mesenteric excision are the main standards of treatment for locally advanced rectal cancer(LARC).Lymph node regression grade(LRG)is an indicator of prognosis and res...Neoadjuvant chemoradiotherapy(nCRT)and total rectal mesenteric excision are the main standards of treatment for locally advanced rectal cancer(LARC).Lymph node regression grade(LRG)is an indicator of prognosis and response to preoperative nCRT based on postsurgical metastatic lymph node pathology.Common histopathological findings in metastatic lymph nodes after nCRT include necrosis,hemorrhage,nodular fibrosis,foamy histiocytes,cystic cell reactions,areas of hyalinosis,residual cancer cells,and pools of mucin.A number of LRG systems designed to classify the amount of lymph node regression after nCRT is mainly concerned with the relationship between residual cancer cells and regressive fibrosis and with estimating the number of lymph nodes existing with residual cancer cells.LRG offers significant prognostic information,and in most cases,LRG after nCRT correlates with patient outcomes.In this review,we describe the systematic classification of LRG after nCRT,patient prognosis,the correlation with tumor regression grade,and the typical histopathological findings of lymph nodes.This work may serve as a reference to help predict the clinical complete response and determine lymph node regression in patients based on preservation strategies,allowing for the formulation of more accurate treatment strategies for LARC patients,which has important clinical significance and scientific value.展开更多
Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and m...Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of atherosclerosis.However,it is unclear how the above factors interact in this setting.In this study,we investigated the role of P-selectin and its receptor,P-selectin glycoprotein ligand(PSGL)-1 in atherosclerosis,with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in the PGSL-1+DCs group,with CD40 and CD86 expressed by 3.84%and 2.05%for the latter.The highest expression of CD80,CD83,and MHC II was discovered in the DC group,at 7.49%,3.68%,and 8.98%,respectively.Results of this study are similar to those obtained previously by Ye et al.(2017),which showed larger atherosclerotic lesions in mice that received exogenous DCs,compared with those treated with PBS.In this study,the greatest level of atherosclerosis,fibrosis,and lipid deposition was also seen in mice that received exogenous DCs.展开更多
Changes in the water cycle on the Tibetan Plateau(TP)have a significant impact on local agricultural production and livelihoods and its downstream regions.Against the background of widely reported warming and wetting,...Changes in the water cycle on the Tibetan Plateau(TP)have a significant impact on local agricultural production and livelihoods and its downstream regions.Against the background of widely reported warming and wetting,the hydrological cycle has accelerated and the likelihood of extreme weather events and natural disasters occurring(i.e.,snowstorms,floods,landslides,mudslides,and ice avalanches)has also intensified,especially in the highelevation mountainous regions.Thus,an accurate estimation of the intensity and variation of each component of the water cycle is an urgent scientific question for the assessment of plateau environmental changes.Following the transformation and movement of water between the atmosphere,biosphere and hydrosphere,the authors highlight the urgent need to strengthen the three-dimensional comprehensive observation system(including the eddy covariance system;planetary boundary layer tower;profile measurements of temperature,humidity,and wind by microwave radiometers,wind profiler,and radiosonde system;and cloud and precipitation radars)in the TP region and propose a practical implementation plan.The construction of such a three-dimensional observation system is expected to promote the study of environmental changes and natural hazards prevention.展开更多
Purpose: Increased conjunctival arteries and lymphangions accelerate the cellular immune response in recurrent pterygium, however, which plays a more important role warrants further investigation. The aim of the study...Purpose: Increased conjunctival arteries and lymphangions accelerate the cellular immune response in recurrent pterygium, however, which plays a more important role warrants further investigation. The aim of the study is to compare the roles of lymphatic and blood vessels in pterygium recurrence. Methods: Histological sections from 48 excised recurrent pterygia (including 14 Grade 1, 20 Grade 2, and 14 Grade 3 tissues) were examined. Histological sections from seven nasal epibulbar conjunctival segments served as normal controls. Blood and lymphatic vessels were evaluated and compared according to blood microvessel density (BMD), blood vascular area (BVA), lymphatic microvessel density (LMD), and lymph-vascular area (LVA). Furthermore, the following relationships were analyzed: LMD and pterygium recurrence time (RT), LVA and RT, BMD and RT, BVA and RT. Results: Compared to LVA, LMD, BVA, and BVD values in normal control tissues, these values were markedly enhanced in recurrent pterygia tissues. The LMD/BMD and LVA/BVA ratios were significant increased in Grade 2 and 3 recurrent pterygia, suggesting that development of conjunctival lymphangions was not proportional to blood vessel growth. LMD, LVA and BVA were significantly correlated with RT for all grades of pterygia, while BMD was the only factor correlated with RT in Grade 1 pterygia. Moreover, no significant correlation was found between BMD and RT in Grade 2 and 3 pterygia. Conclusion: Compared to blood vessels, lymphangions might have a greater impact on pterygium recurrence.展开更多
Surface energy budget components(such as net radiation flux,sensible heat flux,latent heat flux and soil heat flux)at multiple temporal scales have significant meaning for understanding the energy and water cycle over...Surface energy budget components(such as net radiation flux,sensible heat flux,latent heat flux and soil heat flux)at multiple temporal scales have significant meaning for understanding the energy and water cycle over the Tibetan Plateau(TP).In the framework of ESA-MOST Dragon Programme 4,the surface energy balance system(SEBS)was tested and used to derive surface heat fluxes at different temporal scales over the TP by a combination use of geostationary satellite(FY-2 C)data,polar orbiting satellite(SPOT/VGT,Terra/MODIS)data and ITPCAS forcing data.The validation results show there is a good agreement between derived heat fluxes and in situ measurements from Third Pole Environment Observation and Research Platform(TPEORP),which means the feasibility to derive surface heat fluxes over heterogeneous landscapes by a combination use of geostationary and polar orbiting satellite data in SEBS.The diurnal,seasonal and inter-annual variation characteristics were also clearly identified through analyses of derived turbulent fluxes.展开更多
基金supported by Hong Kong Spinal Cord Injury Fund (HKSCIF),China (to HZ)。
文摘For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein thrombosis.Surgery is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury patients.Development of effective therapies fo r chronic spinal co rd injury patients is needed.We conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive rehabilitation.This clinical trial was registered at ClinicalTrials.gov(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord compression.We found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training alone.Overall,the surgical procedures and intensive rehabilitation were safe.American Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 injuries.Surgery combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.
基金supported by the Second Comprehensive Scientific Research Survey on the Tibetan Plateau[grant number 2019QZKK0103]the National Natural Science Foundation of China[grant numbers 42375071 and 42230610].
文摘The alpine meadow ecosystem accounts for 27%of the total area of the Tibetan Plateau and is also one of the most important vegetation types.The Dangxiong alpine meadow ecosystem,located in the south-central part of the Tibetan Plateau,is a typical example.To understand the carbon and water fluxes,water use efficiency(WUE),and their responses to future climate change for the alpine meadow ecosystem in the Dangxiong area,two parameter estimation methods,the Model-independent Parameter Estimation(PEST)and the Dynamic Dimensions Search(DDS),were used to optimize the Biome-BGC model.Then,the gross primary productivity(GPP)and evapotranspiration(ET)were simulated.The results show that the DDS parameter calibration method has a better performance.The annual GPP and ET show an increasing trend,while the WUE shows a decreasing trend.Meanwhile,ET and GPP reach their peaks in July and August,respectively,and WUE shows a“dual-peak”pattern,reaching peaks in May and November.Furthermore,according to the simulation results for the next nearly 100 years,the ensemble average GPP and ET exhibit a significant increasing trend,and the growth rate under the SSP5–8.5 scenario is greater than that under the SSP2–4.5 scenario.WUE shows an increasing trend under the SSP2–4.5 scenario and a significant increasing trend under the SSP5–8.5 scenario.This study has important scientific significance for carbon and water cycle prediction and vegetation ecological protection on the Tibetan Plateau.
基金supported in part by collaborative research with Toyota Motor Corporation,in part by ROIS NII Open Collaborative Research under Grant 21S0601,in part by JSPS KAKENHI under Grants 20H00592,21H03424.
文摘With the rapid development of artificial intelligence and the widespread use of the Internet of Things, semantic communication, as an emerging communication paradigm, has been attracting great interest. Taking image transmission as an example, from the semantic communication's view, not all pixels in the images are equally important for certain receivers. The existing semantic communication systems directly perform semantic encoding and decoding on the whole image, in which the region of interest cannot be identified. In this paper, we propose a novel semantic communication system for image transmission that can distinguish between Regions Of Interest (ROI) and Regions Of Non-Interest (RONI) based on semantic segmentation, where a semantic segmentation algorithm is used to classify each pixel of the image and distinguish ROI and RONI. The system also enables high-quality transmission of ROI with lower communication overheads by transmissions through different semantic communication networks with different bandwidth requirements. An improved metric θPSNR is proposed to evaluate the transmission accuracy of the novel semantic transmission network. Experimental results show that our proposed system achieves a significant performance improvement compared with existing approaches, namely, existing semantic communication approaches and the conventional approach without semantics.
基金funded by the Second Tibetan Plateau Scientific Expedition and Research(STEP)Program(Grant No.2019QZKK0103)National Natural Science Foundation of China(Grant Nos.41875031,42230610,41522501,41275028)CLIMATE-Pan-TPE in the framework of the ESA-MOST Dragon 5 Programme(Grant ID 58516)。
文摘Evapotranspiration(ET)is a crucial variable in the terrestrial water,carbon,and energy cycles.At present,a large number of multi source ET products exist.Due to sparse observations,however,great challenges exist in the evaluation and integration of ET products in remote and complex areas such as the Tibetan Plateau(TP).In this paper,the applicability of the multiple collocation(MC)method over the TP is evaluated for the first time,and the uncertainty of multisource ET products(based on reanalysis,remote sensing,and land surface models)is further analyzed,which provides a theoretical basis for ET data fusion.The results show that 1)ET uncertainties quantified via the MC method are lower in RS-based ET products(5.95 vs.7.06 mm month^(-1))than in LSM ET products(10.22 vs.17.97 mm month^(-1))and reanalysis ET estimates(7.27 vs.12.26 mm month-1).2)A multisource evapotranspiration(MET)dataset is generated at a monthly temporal scale with a spatial resolution of 0.25°across the TP during 2005-15.MET has better performance than any individual product.3)Based on the fusion product,the total ET amount over the TP and its patterns of spatiotemporal variability are clearly identified.The annual total ET over the entire TP is approximately 380.60 mm.Additionally,an increasing trend of 1.59±0.85 mm yr^(-1)over the TP is shown during 2005-15.This study provides a basis for future studies on water and energy cycles and water resource management over the TP and surrounding regions.
基金supported by the National Natural Science Foundation of China.Project under Grant(Nos.51966018 and 51466015).
文摘A combined experimental and numerical research study is conducted to investigate the complex relationship between the structure and the aerodynamic performances of an Archimedes spiral wind turbine(ASWT).Two ASWTs are considered,a prototypical version and an improved version.It is shown that the latter achieves the best aerodynamic performance when the spread angles at the three sets of blades areα_(1)=30°,α_(2)=55°,α3=60°,respectively and the blade thickness is 4 mm.For a velocity V=10 m/s,a tip speed ratio(TSR)=1.58 and 2,the maximum CP values are 0.223 and 0.263 for the prototypical ASWT and improved ASWT,respectively,and the maximum C_(P) enhancement is 17.93%.For V=10 m/s and TSR=2,the CP values of the prototypical ASWT and improved ASWT are 0.225 and 0.263,respectively,with an aerodynamic performance enhancement of 16.88%.Through mutual verification of the test outcomes and numerical results,it is concluded that the proposed approach can effectively lead to aerodynamic performance improvement.
基金supported by the National Key R&D Program of China (2017YFD0400205)Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX19_1402)
文摘Soy protein isolate(SPI)is a commercial protein with balanced amino acids,while the poor solubility impedes its use in traditional foods.To overcome the problem,the complex coacervation of SPI/Flammulina velutipes polysaccharide(FVP)were investigated.Initial results revealed that the suitable amounts of FVP contributed to reducing the turbidity of SPI solution.Under electrostatic interaction,the formation of SPI/FVP coacervates were spontaneous and went through a nucleation and growth process.Low salt concentration(C_(NaCl)=10,50 mmol/L)led to an increase in the critical pH values(pHc,pHφ1)while the critical pH values decreased when C_(NaCl)≥100 mmol/L.The concentration of NaCl ions increased the content ofα-helix.With the increase of FVP,the critical pH values decreased and the content ofβ-sheet increased through electrostatic interaction.At SPI/FVP ratio of 10:1 and 15:1,the complex coacervation of SPI/FVP were saturated,and the coacervates had the same storage modulus value.SPI/FVP coacervates exhibited solid-like properties and presented the strongest storage modulus at C_(NaCl)=50 mmol/L.The optimal pH,SPI/FVP ratio and NaCl concentration of complex coacervation were collected,and the coacervates demonstrated a valuable application potential to protect and deliver bioactives and food ingredients.
基金the financial support from the National Natural Science Foundation of China(22108044,22208061)the Research and Development Program in Key Fields of Guangdong Province(2020B1111380002)+1 种基金the Basic Research and Applicable Basic Research in Guangzhou City(202201010290)the financial support from the Guangdong Provincial Key Laboratory of Plant Resources Biorefinery(2021GDKLPRB07)。
文摘Amorphous carbons are promising anodes for high-rate potassium-ion batteries.Most low-temperature annealed amorphous carbons display unsatisfactory capacities.Heteroatom-induced defect engineering of amorphous carbons could enhance their reversible capacities.Nevertheless,most lignocellulose biomasses lack heteroatoms,making it a challenge to design highly heteroatom-doped carbons(>10 at%).Herein,we report a new preparation strategy for amorphous carbon anodes.Nitrogen/sulfur co-doped lignin-derived porous carbons(NSLPC)with ultra-high nitrogen doping levels(21.6 at%of N and 0.8 at%of S)from renewable lignin biomacromolecule precursors were prepared through a supramolecule-mediated pyrolysis strategy.This supermolecule/lignin composite decomposes forming a covalently bonded graphitic carbon/amorphous carbon intermediate product,which induces the formation of high heteroatom doping in the obtained NSLPC.This unique pyrolysis chemistry and high heteroatom doping of NSLPC enable abundant defective active sites for the adsorption of K+and improved kinetics.The NSLPC anode delivered a high reversible capacity of 419 mAh g^(-1)and superior cycling stability(capacity retention of 96.6%at 1 A g^(-1)for 1000 cycles).Potassiumion hybrid capacitors assembled by NSLPC anode exhibited excellent cycling stability(91%capacity retention for 2000 cycles)and a high energy density of 71 Wh kg^(-1)at a power density of 92 W kg^(-1).
基金supported by the Special Funds for Scientific and Technological Achievement Transformation Project in Jiangsu Province(BA2021062).
文摘Flammulina velutipes(F.velutipes)polysaccharides were modified by ultrasound at the rated power of 150 W and 900 W.The monosaccharide composition,ultraviolet-visible,and Fourier transform infrared spectral characteristics of F.velutipes polysaccharides(FVP)and their ultrasonic modification products(U-FVPs)were determined.The protective effects of FVP and U-FVPs on human gastric mucosal cells GES-1 were confi rmed for the first time.The mole ratios of glucose and galactose were decreased and the mole ratio of mannose was increased after ultrasonic modification.Compared with the original FVP and the FVP modifi ed by ultrasound of 150 W(U-FVP1),the FVP modifi ed by ultrasound of 900 W(U-FVP2)could better prevent ethanol-induced damage to GES-1 cells.With increasing ultrasound intensity,the protective effect of FVPs on GES-1 cells was significantly enhanced by more effective prevention of intracellular reactive oxygen species(ROS)production and more promotion of expression of triglyceride factor 2(TFF2),prostaglandin E2(PGE2),epidermal growth factor(EGF),and transforming growth factorβ1(TGF-β1)mRNA.The ultrasonic modifi cation might be an effective way to develop novel F.velutipes polysaccharides that could effectively resist the gastric injury caused by excessive alcohol consumption.
基金Supported by the Young Talent Program of Gusu Health Project(No.GSWS2020014)。
文摘AIM:To describe the subcutaneous pedicled propeller flap technique for the microscopic reconstruction of eyelid defects and evaluate its outcomes.METHODS:The clinical data of 23 patients(23 eyes)who underwent microscopic reconstruction of eyelid defects with the subcutaneous pedicled propeller flap technique were retrospectively analyzed.All patients underwent eyelid tumor resection and one-stage microscopic reconstruction with the subcutaneous pedicled propeller flap for anterioror posterior-layer eyelid defects.The survival rate of the propeller flap,eyelid function and appearance,tumor recurrence rate,and patient satisfaction were evaluated after the surgery.RESULTS:The patients consisted of 12 men and 11 women,aged 31–82y(mean,58.9y).The longest followup time was 5y,and the shortest was 3mo.All the propeller flaps survived well.There was no significant difference in color and luster between the flap and adjacent tissues,and there was no dog ear phenomenon.No obvious scarring was observed.There were no obvious abnormalities of eyelid morphology or function,and no adverse complications such as exposure keratitis,entropion,ectropion,ptosis,and eyelid retraction.No tumor recurrence was found at the time of the last follow-up.All patients were satisfied with the surgical results.CONCLUSION:The subcutaneous pedicled propeller flap technique for the microscopic reconstruction of eyelid defects has satisfactor y outcomes in terms of eyelid function and esthetics,and merits clinical application.
基金Supported by National Education Department"ChunHui Plan"Research Projects,No.Z2010021China Postdoctoral Science Foundation Project,No.2013M531079+2 种基金Heilongjiang Postdoctoral Funding Project,No.LBH-Z12246Heilongjiang Education Department Scientific Research Project,No.12521502excellent Innovative Talents Support Program Funding of Heilongjiang University of Chinese Medicine(Outstanding Young Academic Leaders),No.051217
文摘AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral hypersensitivity.in normal rats and 4.5 ± 1.58 in IBS model rats(P < 0.001). However, the defecation frequency was significantly decreased(3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time(in seconds) of colon transit function was significantly increased(256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.
基金supported by the National Natural Science Foundation of China NSFC (Grant Nos.91837310,42061134009,41775146)the USTC Research Funds of the Double First-Class Initiative (YD2080002007)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB41000000)
文摘The non-hydrostatic global variable resolution model(MPAS-atmosphere)is used to conduct the simulations for the South Asian Summer monsoon season(June,July,and August)in 2015 with a refinement over the Tibetan Plateau(TP)at the convection-permitting scale(4 km).Two experiments with different topographical datasets,complex(4-km)and smooth(60-km)topography,are designed to investigate the impacts of topographical complexity on moisture transport and precipitation.Compared with the observations and reanalysis data,the simulation can successfully capture the general features of key meteorological fields over the TP despite slightly underestimating the inflow through the southern TP.The results indicate that the complex topography can decrease the inward and outward moisture transport,ultimately increasing the total net moisture transport into the TP by~11%.The impacts of complex topography on precipitation are negligible over the TP,but the spatial distributions of precipitation over the Himalayas are significantly modulated.With the inclusion of complex topography,the sharper southern slopes of the Himalayas shift the lifted airflow and hence precipitation northward compared to the smooth topography.In addition,more small-scale valleys are resolved by the inclusion of complex topography,which serve as channels for moisture transport across the Himalayas,further favoring a northward shift of precipitation.Overall,the difference between the two experiments with different topography datasets is mainly attributed to their differing representation of the degree of the southern slopes of the Himalayas and the extent to which the valleys are resolved.
文摘AIMTo expose rat retinal Müller cells to 530 nm monochromatic light and investigate the influence of varying light illumination times on basic fibroblast growth factor (bFGF) and transforming growth factor-β1 (TGF-β1) expression.METHODSThree groups of rat retinal Müller cells cultured in vitro under a 530 nm monochromatic light were divided into 6, 12 and 24h experimental groups, while cells incubated under dark conditions served as the control group. The bFGF and TGF-β1 mRNA expression, protein levels and fluorescence intensity of the Müller cells were analyzed.RESULTSThe bFGF mRNA expression and protein levels were significantly upregulated in Müller cells in all three experimental groups compared with the control group (P<0.05), while that of TGF-β1 was downregulated (P<0.05). Also, bFGF expression was positively correlated, but TGF-β1 expression was negatively correlated with illumination time. The largest changes for both cytokines were seen in the 24h group. The changes in bFGF and TGF-β1 fluorescence intensity were highest in the 24h group, and significant differences were observed among the experimental groups (P<0.05).CONCLUSIONThe expressions of bFGF and TGF-β1 changed in a time-dependent manner in Müller cells exposed to 530 nm monochromatic light with 250 lx illumination intensity. Müller cells might play a role in the development of myopia by increasing bFGF expression or decreasing TGF-β1 expression. Changes in cytokine expression in retinal Müller cells may affect monochromatic light-induced myopia.
基金Supported by Chengdu Science and Technology Project,No. 2021-YF05-01484-SNExcellent Youthof Sichuan Cancer Hospital,No. YB2021037Health Commission of Sichuan Province,No. 20PJ112
文摘Neoadjuvant chemoradiotherapy(nCRT)and total rectal mesenteric excision are the main standards of treatment for locally advanced rectal cancer(LARC).Lymph node regression grade(LRG)is an indicator of prognosis and response to preoperative nCRT based on postsurgical metastatic lymph node pathology.Common histopathological findings in metastatic lymph nodes after nCRT include necrosis,hemorrhage,nodular fibrosis,foamy histiocytes,cystic cell reactions,areas of hyalinosis,residual cancer cells,and pools of mucin.A number of LRG systems designed to classify the amount of lymph node regression after nCRT is mainly concerned with the relationship between residual cancer cells and regressive fibrosis and with estimating the number of lymph nodes existing with residual cancer cells.LRG offers significant prognostic information,and in most cases,LRG after nCRT correlates with patient outcomes.In this review,we describe the systematic classification of LRG after nCRT,patient prognosis,the correlation with tumor regression grade,and the typical histopathological findings of lymph nodes.This work may serve as a reference to help predict the clinical complete response and determine lymph node regression in patients based on preservation strategies,allowing for the formulation of more accurate treatment strategies for LARC patients,which has important clinical significance and scientific value.
基金the National Natural Science Foundation of China(Grant Nos.81770340,81100220).
文摘Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of atherosclerosis.However,it is unclear how the above factors interact in this setting.In this study,we investigated the role of P-selectin and its receptor,P-selectin glycoprotein ligand(PSGL)-1 in atherosclerosis,with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in the PGSL-1+DCs group,with CD40 and CD86 expressed by 3.84%and 2.05%for the latter.The highest expression of CD80,CD83,and MHC II was discovered in the DC group,at 7.49%,3.68%,and 8.98%,respectively.Results of this study are similar to those obtained previously by Ye et al.(2017),which showed larger atherosclerotic lesions in mice that received exogenous DCs,compared with those treated with PBS.In this study,the greatest level of atherosclerosis,fibrosis,and lipid deposition was also seen in mice that received exogenous DCs.
基金This research was jointly funded by the Second Tibetan Plateau Scientific Expedition and Research Program(Grant Nos.2019QZKK0103 and 2019QZKK0105)the National Natural Science Foundation of China(Grant Nos.91837208 and 42075085).
文摘Changes in the water cycle on the Tibetan Plateau(TP)have a significant impact on local agricultural production and livelihoods and its downstream regions.Against the background of widely reported warming and wetting,the hydrological cycle has accelerated and the likelihood of extreme weather events and natural disasters occurring(i.e.,snowstorms,floods,landslides,mudslides,and ice avalanches)has also intensified,especially in the highelevation mountainous regions.Thus,an accurate estimation of the intensity and variation of each component of the water cycle is an urgent scientific question for the assessment of plateau environmental changes.Following the transformation and movement of water between the atmosphere,biosphere and hydrosphere,the authors highlight the urgent need to strengthen the three-dimensional comprehensive observation system(including the eddy covariance system;planetary boundary layer tower;profile measurements of temperature,humidity,and wind by microwave radiometers,wind profiler,and radiosonde system;and cloud and precipitation radars)in the TP region and propose a practical implementation plan.The construction of such a three-dimensional observation system is expected to promote the study of environmental changes and natural hazards prevention.
文摘Purpose: Increased conjunctival arteries and lymphangions accelerate the cellular immune response in recurrent pterygium, however, which plays a more important role warrants further investigation. The aim of the study is to compare the roles of lymphatic and blood vessels in pterygium recurrence. Methods: Histological sections from 48 excised recurrent pterygia (including 14 Grade 1, 20 Grade 2, and 14 Grade 3 tissues) were examined. Histological sections from seven nasal epibulbar conjunctival segments served as normal controls. Blood and lymphatic vessels were evaluated and compared according to blood microvessel density (BMD), blood vascular area (BVA), lymphatic microvessel density (LMD), and lymph-vascular area (LVA). Furthermore, the following relationships were analyzed: LMD and pterygium recurrence time (RT), LVA and RT, BMD and RT, BVA and RT. Results: Compared to LVA, LMD, BVA, and BVD values in normal control tissues, these values were markedly enhanced in recurrent pterygia tissues. The LMD/BMD and LVA/BVA ratios were significant increased in Grade 2 and 3 recurrent pterygia, suggesting that development of conjunctival lymphangions was not proportional to blood vessel growth. LMD, LVA and BVA were significantly correlated with RT for all grades of pterygia, while BMD was the only factor correlated with RT in Grade 1 pterygia. Moreover, no significant correlation was found between BMD and RT in Grade 2 and 3 pterygia. Conclusion: Compared to blood vessels, lymphangions might have a greater impact on pterygium recurrence.
基金supported by CLIMATE-TPE(ID:32070)in the framework of the ESA-MOST Dragon 4 Programme。
文摘Surface energy budget components(such as net radiation flux,sensible heat flux,latent heat flux and soil heat flux)at multiple temporal scales have significant meaning for understanding the energy and water cycle over the Tibetan Plateau(TP).In the framework of ESA-MOST Dragon Programme 4,the surface energy balance system(SEBS)was tested and used to derive surface heat fluxes at different temporal scales over the TP by a combination use of geostationary satellite(FY-2 C)data,polar orbiting satellite(SPOT/VGT,Terra/MODIS)data and ITPCAS forcing data.The validation results show there is a good agreement between derived heat fluxes and in situ measurements from Third Pole Environment Observation and Research Platform(TPEORP),which means the feasibility to derive surface heat fluxes over heterogeneous landscapes by a combination use of geostationary and polar orbiting satellite data in SEBS.The diurnal,seasonal and inter-annual variation characteristics were also clearly identified through analyses of derived turbulent fluxes.