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Association of four GSTs gene polymorphisms with Parkinson disease: A meta-analysis
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作者 Dongjun Dai Yunliang Wang +15 位作者 Lingyan Wang Jinfeng Li Hanlin Zhou Qingqing Ma Xingyu Zhou Jun Pan Guanghui Pan Cheng Chen Limin xu Ping Ru Hui Wang Shengqian Zhu Yuelong Lv leiting xu Meng Ye Shiwei Duan 《Advances in Bioscience and Biotechnology》 2014年第2期100-107,共8页
Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathion... Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathione S-transferases (GSTs) are dimeric cytosolic enzymes with an important role in the pathogenesis of PD. The aim of this study was to evaluate the association between the polymorphisms of GST genes and PD. Meta-analyses were conducted from 17 studies (38 stages) among 3419 cases and 5686 controls between four polymorphisms (GSTT1 deletion polymorphism;GSTM1 deletion polymorphism;GSTP1-104: rs1695;GSTP1-114: rs1799811) and PD. There is no significant association between the four GST gene variants and PD. A further subgroup study by ethnicity observed a risky role of GSTM1 deletion polymorphism with PD in Europeans (p = 0.013, OR = 1.126, 95% CI = 1.025-1.236), and a protective role of GSTM1 deletion polymorphism with PD in Latin Americans (p = 0.032, OR = 0.750, 95% CI = 0.577-0.975). Our meta-analysis suggested that GSTM1 deletion polymorphism increased the risk of PD in Europeans, but reduced the risk of PD in Latin Americans. Future large-scale studies might be needed to confirm the ethnic difference of GSTM1 deletion polymorphism, and to check whether there was significant association of PD for other GST genetic polymorphisms. 展开更多
关键词 Parkinson GSTM1 Deletion Polymorphism META-ANALYSIS Europeans GSTT1 GSTP1
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A comprehensive meta-analysis of the association between three <i>IL</i>1B polymorphisms and rheumatoid arthritis
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作者 Dongjun Dai Lingyan Wang +13 位作者 Limin xu Lingling Tang xuting xu Huadan Ye Xingyu Zhou Cheng Chen Guanghui Pan Ping Ru Qingqing Ma Yi Jiang Wenjing Yu leiting xu Meng Ye Shiwei Duan 《Advances in Bioscience and Biotechnology》 2014年第2期108-116,共9页
Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of i... Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate the association between IL1B polymorphisms and RA. A meta-analysis was performed on the association between three IL1B polymorphisms (IL1B-31: rs1143627;IL1B-511: rs16944;IL1B + 3954: rs1143634) and RA. A trend of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T played a protective role against RA in Europeans, and that IL1B + 3954-T had the potential to increase the risk of RA. Future large-scale studies should be considered to confirm the association between IL1B polymorphisms and RA. 展开更多
关键词 RHEUMATOID ARTHRITIS META-ANALYSIS Polymorphism IL1B-511 Dominant Model
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Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia
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作者 xuting xu Lingyan Wang +7 位作者 Qi Liao leiting xu Yi Huang Fuqiang Zhang Jia Cheng Meng Ye Shugui Gao Shiwei Duan 《Advances in Bioscience and Biotechnology》 2014年第2期81-88,共8页
The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility to schizophrenia (SCZ). The authors conducted meta-analyses on associations between SCZ and 9 variants of 6 genes includin... The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility to schizophrenia (SCZ). The authors conducted meta-analyses on associations between SCZ and 9 variants of 6 genes including PIK3C3 (432C > T), ABCB1 (C3435T and G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340, rs3749034 and rs769395), and GRIN1 (G1001C). A total of 34 case-control studies were involved in our meta-analyses. Our results showed no significant association between all the loci and SCZ. This meta-analysis confirmed a lack of association of SCZ for 9 genetic polymorphisms including GRIN1 G1001C, ABCB1 C3435T and G2677T, CTLA4 + 49A/G, OLIG2 rs762178, GAD1 gene rs1978340, rs3749034 and rs769395, and PIK3C3 432C > T. 展开更多
关键词 SCHIZOPHRENIA META-ANALYSIS SNP
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