Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and...Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and its role in animal physiology. In pigs, the interactions between valine and other branched-chain amino acids or aromatic amino acids are complex. In this review, we delve into the interaction mechanism, metabolic pathways, and biological functions of valine. Appropriate valine supplementation not only enhances growth and reproductive performances, but also modulates gut microbiota and immune functions. Based on past observations and interpretations, we provide recommended feed levels of valine for weaned piglets, growing pigs, gilts, lactating sows, barrows and entire males. The summarized valine nutrient requirements for pigs at different stages offer valuable insights for future research and practical applications in animal husbandry.展开更多
Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understa...Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and diseases.Of relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.展开更多
In swine production,stress is a common encounter that leads to serious bacterial infection and adverse effects on growth performance.Though antibiotics have been frequently used to control pathogen spread,sustained ne...In swine production,stress is a common encounter that leads to serious bacterial infection and adverse effects on growth performance.Though antibiotics have been frequently used to control pathogen spread,sustained negative impacts from antibiotics have been found to affect intestinal integrity and the immune system.Multiple nutritional strategies have shown potential to counteract stress and replace antibiotics,including functional amino acids,low protein diet,plant extracts,organic acids,prebiotics,probiotics,minerals and vitamins.These additives relieve the stress response in swine via different mechanisms and signal transduction pathways.Based on the overview of signaling pathways and stress models,this review highlights the potential of nutritional strategies in swine for preventing or treating stress-related health problems.For wider application in the pig industry,the dose ranges measured require for further validation in different physiological contexts and formulations.In the future,micro-fluid devices and novel stress models are expected to enhance the efficiency of screening for new anti-stress candidates.展开更多
基金supported by Postdoctoral Innovation Talents’ Support Programthe National Natural Science Foundation of China (32130099)+1 种基金the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-CXRC-038)Laboratory of Lingnan Modern Agriculture Project (NT2021005)。
文摘Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branchedchain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and its role in animal physiology. In pigs, the interactions between valine and other branched-chain amino acids or aromatic amino acids are complex. In this review, we delve into the interaction mechanism, metabolic pathways, and biological functions of valine. Appropriate valine supplementation not only enhances growth and reproductive performances, but also modulates gut microbiota and immune functions. Based on past observations and interpretations, we provide recommended feed levels of valine for weaned piglets, growing pigs, gilts, lactating sows, barrows and entire males. The summarized valine nutrient requirements for pigs at different stages offer valuable insights for future research and practical applications in animal husbandry.
基金supported by the National Key Research and Development Program of China(2021YFD1300700,2021YFD1300201,2022YFA1304201)the National Natural Science Foundation of China(32225047,U22A20510,32125036,32172750,31972596,31902170,31630074,32272916,32102567)+4 种基金the Laboratory of Lingnan Modern Agriculture Project(NT2021005)the China Agricultural Research System of MOF and MARA(CARS-35)the Key Research and Development Project of Hainan Province(ZDYF2021XDNY177)the 111 Project(B16044)the Program for Shaanxi Science and Technology(2022KJXX-13).
文摘Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and diseases.Of relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.
基金supported by the National Natural Science Foundation of China(32130099)Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-CXRC-038)Laboratory of Lingnan Modern Agriculture Project(NT2021005).
文摘In swine production,stress is a common encounter that leads to serious bacterial infection and adverse effects on growth performance.Though antibiotics have been frequently used to control pathogen spread,sustained negative impacts from antibiotics have been found to affect intestinal integrity and the immune system.Multiple nutritional strategies have shown potential to counteract stress and replace antibiotics,including functional amino acids,low protein diet,plant extracts,organic acids,prebiotics,probiotics,minerals and vitamins.These additives relieve the stress response in swine via different mechanisms and signal transduction pathways.Based on the overview of signaling pathways and stress models,this review highlights the potential of nutritional strategies in swine for preventing or treating stress-related health problems.For wider application in the pig industry,the dose ranges measured require for further validation in different physiological contexts and formulations.In the future,micro-fluid devices and novel stress models are expected to enhance the efficiency of screening for new anti-stress candidates.
