Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with in...Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with inducible Caspase 9,the enzyme that initiates intrinsic apoptosis,we triggered apoptosis in a proportion of mature osteocalcin(OCN^(+))osteoblasts and investigated the impact on postnatal bone development.展开更多
基金supported in part by funding from the National Institutes of Health (DK053904,DE022327,AR077539,CA093900,CA046592 and P30 AR069620)National Health and Medical Research Council (APP1143802)Mater Foundation.
文摘Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with inducible Caspase 9,the enzyme that initiates intrinsic apoptosis,we triggered apoptosis in a proportion of mature osteocalcin(OCN^(+))osteoblasts and investigated the impact on postnatal bone development.
