We describe an optomechanical ratchet scheme to realize nonreciprocal transmission of a light field, which is based on the bias of the optical cavity’s frequency spectrum caused by mechanical ratchet interactions. Th...We describe an optomechanical ratchet scheme to realize nonreciprocal transmission of a light field, which is based on the bias of the optical cavity’s frequency spectrum caused by mechanical ratchet interactions. This approach to break the time-reversal symmetry of light propagation is universally valid in various optomechanical systems with ratchet-oscillator structures. We discuss specifically the implementation of an on-chip Casimir-ratchet optomechanical protocol and demonstrate the optical nonreciprocity with an extremely high isolation ratio and flexible controllability, which does not require external additional optical engineering. Our study opens a door for manipulating flexibly light propagation by using mechanical ratchet resonators, and has potential applications in the on-chip integration of nonreciprocal devices and harness of lateral Casimir forces.展开更多
Objective:This study aimed to elucidate the possible mechanism of Gest-Aid Plus Oral Liquid(GAP)on healthcare function.Method:Ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-bas...Objective:This study aimed to elucidate the possible mechanism of Gest-Aid Plus Oral Liquid(GAP)on healthcare function.Method:Ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics and 16S rDNA sequencing of gut microbiota were performed on serum and fecal samples of GAP and control rats.Additionally,short-chain fatty acids(SCFAs)and inflammatory cytokines in fecal samples were determined through gas chromatography-mass spectrometry and enzyme-linked immunosorbent assay kits.Result:Metabolomics discovered 41 metabolites,which mainly involved amino acid metabolism,lipid metabolism,coenzyme factors,and vitamin metabolism.Administration of GAP increased abundance of Prevotella_9,Alloprevotella,Blautia,Phascolarctobacterium,Parabacteroides,and Fusicatenibacter,and six SCFAs were increased in the GAP group.Measurement of inflammatory cytokines showed that GAP had an anti-inflammatory effect in rats.Conclusions:Administration of GAP greatly affects the aspartate metabolism and microecology of rats,enhances intestinal motility and gut barrier integrity and anti-inflammation.These findings not only have possible implications for further application of GAP,but also provide a link between the gut microbiome,SCFAs,inflammation and serum metabolites in rats.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12065008)the Key Project of Youth Science Foundation of Jiangxi Province(Grant No.20192ACBL21001)+2 种基金the Outstanding Youth Project of Jiangxi Province(Grant No.20192BCBL23007)supported by the National Natural Science Foundation of China(Grant No.11775190)supported by the National Natural Science Foundation of China(Grant No.11775035)。
文摘We describe an optomechanical ratchet scheme to realize nonreciprocal transmission of a light field, which is based on the bias of the optical cavity’s frequency spectrum caused by mechanical ratchet interactions. This approach to break the time-reversal symmetry of light propagation is universally valid in various optomechanical systems with ratchet-oscillator structures. We discuss specifically the implementation of an on-chip Casimir-ratchet optomechanical protocol and demonstrate the optical nonreciprocity with an extremely high isolation ratio and flexible controllability, which does not require external additional optical engineering. Our study opens a door for manipulating flexibly light propagation by using mechanical ratchet resonators, and has potential applications in the on-chip integration of nonreciprocal devices and harness of lateral Casimir forces.
文摘Objective:This study aimed to elucidate the possible mechanism of Gest-Aid Plus Oral Liquid(GAP)on healthcare function.Method:Ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics and 16S rDNA sequencing of gut microbiota were performed on serum and fecal samples of GAP and control rats.Additionally,short-chain fatty acids(SCFAs)and inflammatory cytokines in fecal samples were determined through gas chromatography-mass spectrometry and enzyme-linked immunosorbent assay kits.Result:Metabolomics discovered 41 metabolites,which mainly involved amino acid metabolism,lipid metabolism,coenzyme factors,and vitamin metabolism.Administration of GAP increased abundance of Prevotella_9,Alloprevotella,Blautia,Phascolarctobacterium,Parabacteroides,and Fusicatenibacter,and six SCFAs were increased in the GAP group.Measurement of inflammatory cytokines showed that GAP had an anti-inflammatory effect in rats.Conclusions:Administration of GAP greatly affects the aspartate metabolism and microecology of rats,enhances intestinal motility and gut barrier integrity and anti-inflammation.These findings not only have possible implications for further application of GAP,but also provide a link between the gut microbiome,SCFAs,inflammation and serum metabolites in rats.
