The authors examined 184 residents from Kazakhstan to reveal an association of the CCND1 gene A870G and TP53 gene Arg72Pro polymorphisms with esophageal cancer risk. 86 of them were control group and 98 were patients ...The authors examined 184 residents from Kazakhstan to reveal an association of the CCND1 gene A870G and TP53 gene Arg72Pro polymorphisms with esophageal cancer risk. 86 of them were control group and 98 were patients with esophageal cancer. DNA samples were genotyped by direct sequencing method and TaqMan allelic discrimination method. Statistical analysis was performed using GraphPad InStatTM Software and ＂Case-Control Study Estimating Calculator＂ from TAPOTILI company. A significant association was revealed between CCND1 homozygous genotype （A870A, OR=2.654） and TP53 heterozygous （Arg72Pro, OR= 1.417） and homozygous （Pro72 Pro, OR=2.860） genotypes increased risk of esophageal cancer.展开更多
文摘The authors examined 184 residents from Kazakhstan to reveal an association of the CCND1 gene A870G and TP53 gene Arg72Pro polymorphisms with esophageal cancer risk. 86 of them were control group and 98 were patients with esophageal cancer. DNA samples were genotyped by direct sequencing method and TaqMan allelic discrimination method. Statistical analysis was performed using GraphPad InStatTM Software and ＂Case-Control Study Estimating Calculator＂ from TAPOTILI company. A significant association was revealed between CCND1 homozygous genotype （A870A, OR=2.654） and TP53 heterozygous （Arg72Pro, OR= 1.417） and homozygous （Pro72 Pro, OR=2.860） genotypes increased risk of esophageal cancer.
