Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of...Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of TCGA tumor and normal tissue samples.The difference of CANX expression between AML and normal samples was found by R software.The Kaplan-Meier method and Log-Rank test were used to assess the relationship between CANX expression and patient survival.The R software was used to find correlations between CANX expression,clinical characteristics,drug sensitivity,and immune infiltration in AML.Results:The differential expression of CANX in 13 tumor and normal tissue samples were statistically significant(P<0.05).The high CANX expression was associated with a favorable prognosis(P<0.05),which was validated in GSE37642.The expression of CANX was correlated with age,survival status,FAB stage,and karyotype(P<0.05).High CANX expression,low age and favorable karyotype were independent predictors of a favorable prognosis(P<0.05).CANX expression may affect the sensitivity of AML patients to multiple drugs(P<0.05).The expression of CANX was positively correlated with that of M1 macrophages and CD8 T cells.Conclusion:CANX may be used as a novel potential biomarker,and could benefit AML patients by predicting patient prognosis and providing precise treatment indications.展开更多
Objective:To assess the clinical features of fetal growth restriction(FGR)in women with hypertensive disorders of pregnancy in China.Methods:This is a retrospective cohort study.The clinical data of 4451 women with hy...Objective:To assess the clinical features of fetal growth restriction(FGR)in women with hypertensive disorders of pregnancy in China.Methods:This is a retrospective cohort study.The clinical data of 4451 women with hypertensive disorders of pregnancy were retrospectively collected from 11 tertiary hospitals across ten provinces in China during January 2015 to December 2015.The mean maternal age was(31.0±5.4)years old.Participants were divided into FGR group(n=670)and non-FGR group(n=3781).The incidence and clinical features of FGR,and its correlation with gestational age,previous FGR history,24-hour urinary protein excretion,and hemolysis,elevated liver enzyme and low platelet count(HELLP)syndrome were analyzed.Student’s t-test and Chi-square test were used when comparing clinical features between FGR and non-FGR groups.Results:The overall incidence of FGR was 15.1%(670/4451).The FGR incidence was 22.4%(433/1937)in women with severe preeclampsia and 18.6%(68/365)in women with chronic hypertension with superimposed preeclampsia,respectively.FGR was more prevalent in women who had preterm births than those who had term births(22.8%(432/1898)vs.9.3%(238/2553),P<0.001).It was also more prevalent in women with early-onset preeclampsia than those with late-onset preeclampsia(18.4%(189/1025)vs.14.0%(481/3426),P=0.001).Women with a previous FGR history had a significantly higher FGR incidence than those without an FGR history(66.7%(4/6)vs.15.7%(250/1596),P=0.007).The presence of abnormal results of the umbilical artery Doppler(13%(87/670)vs.2.4%(89/3781),P<0.001)and the middle cerebral artery Doppler(3.3%(22/670)vs.0.4%(15/3781),P<0.001)was higher in the FGR group compared with the non-FGR group,while the presence of increased uterine artery resistance was not statistically different(1.5%(10/670)vs.0.8%(29/3781),P=0.072).The FGR group delivered earlier than the non-FGR group((35.3±3.0)weeks vs.(36.4±4.3)weeks,P<0.001)with lower birth weight(1731.0±574.5)g vs.(2753.9±902.1)g,P<0.001,higher fetal or neonatal death(9.4%(63/670)vs.4.2%(157/3781),P<0.001),and higher cesarean section rate(82.5%(553/670)vs.70.2%(2656/3781),P<0.001).In the FGR group,more neonates had 5-minute Apgar score≤7(7.9%(53/670)vs.3.9%(149/3780),P<0.001),with higher neonatal intensive care unit admission rate(48.1%(322/670)vs.23.3%(881/3781),P<0.001).More cases of HELLP syndrome occurred in the FGR group(6.9%(46/670)vs.3.2%(122/3781),P<0.001).Women with FGR had heavier 24-hour urinary protein excretion than those without FGR((3.9±3.7)g vs.(3.1±4.2)g,P=0.005).Conclusion:In pregnancies with hypertensive disorders,increased risks of FGR are associated with preterm birth,birth before 34 weeks,and a previous FGR history.FGR is related to higher occurrence of abnormal uterine artery Doppler and umbilical artery Doppler.When hypertensive disorders is complicated by FGR,there appears to be higher maternal morbidity including higher rate of HELLP syndrome,cesarean section,and heavier proteinuria,as well as worse neonatal outcomes.展开更多
基金National Natural Science Foundation of China(U1804191)。
文摘Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of TCGA tumor and normal tissue samples.The difference of CANX expression between AML and normal samples was found by R software.The Kaplan-Meier method and Log-Rank test were used to assess the relationship between CANX expression and patient survival.The R software was used to find correlations between CANX expression,clinical characteristics,drug sensitivity,and immune infiltration in AML.Results:The differential expression of CANX in 13 tumor and normal tissue samples were statistically significant(P<0.05).The high CANX expression was associated with a favorable prognosis(P<0.05),which was validated in GSE37642.The expression of CANX was correlated with age,survival status,FAB stage,and karyotype(P<0.05).High CANX expression,low age and favorable karyotype were independent predictors of a favorable prognosis(P<0.05).CANX expression may affect the sensitivity of AML patients to multiple drugs(P<0.05).The expression of CANX was positively correlated with that of M1 macrophages and CD8 T cells.Conclusion:CANX may be used as a novel potential biomarker,and could benefit AML patients by predicting patient prognosis and providing precise treatment indications.
基金Our study was supported by grants from the National Natural Science Foundation of China(No.81701466,81490745)the National Major Scientific Research Program of China(No.2015CB943304)the National Science and Technology Support Program of China(No.2015BAI13B06)
文摘Objective:To assess the clinical features of fetal growth restriction(FGR)in women with hypertensive disorders of pregnancy in China.Methods:This is a retrospective cohort study.The clinical data of 4451 women with hypertensive disorders of pregnancy were retrospectively collected from 11 tertiary hospitals across ten provinces in China during January 2015 to December 2015.The mean maternal age was(31.0±5.4)years old.Participants were divided into FGR group(n=670)and non-FGR group(n=3781).The incidence and clinical features of FGR,and its correlation with gestational age,previous FGR history,24-hour urinary protein excretion,and hemolysis,elevated liver enzyme and low platelet count(HELLP)syndrome were analyzed.Student’s t-test and Chi-square test were used when comparing clinical features between FGR and non-FGR groups.Results:The overall incidence of FGR was 15.1%(670/4451).The FGR incidence was 22.4%(433/1937)in women with severe preeclampsia and 18.6%(68/365)in women with chronic hypertension with superimposed preeclampsia,respectively.FGR was more prevalent in women who had preterm births than those who had term births(22.8%(432/1898)vs.9.3%(238/2553),P<0.001).It was also more prevalent in women with early-onset preeclampsia than those with late-onset preeclampsia(18.4%(189/1025)vs.14.0%(481/3426),P=0.001).Women with a previous FGR history had a significantly higher FGR incidence than those without an FGR history(66.7%(4/6)vs.15.7%(250/1596),P=0.007).The presence of abnormal results of the umbilical artery Doppler(13%(87/670)vs.2.4%(89/3781),P<0.001)and the middle cerebral artery Doppler(3.3%(22/670)vs.0.4%(15/3781),P<0.001)was higher in the FGR group compared with the non-FGR group,while the presence of increased uterine artery resistance was not statistically different(1.5%(10/670)vs.0.8%(29/3781),P=0.072).The FGR group delivered earlier than the non-FGR group((35.3±3.0)weeks vs.(36.4±4.3)weeks,P<0.001)with lower birth weight(1731.0±574.5)g vs.(2753.9±902.1)g,P<0.001,higher fetal or neonatal death(9.4%(63/670)vs.4.2%(157/3781),P<0.001),and higher cesarean section rate(82.5%(553/670)vs.70.2%(2656/3781),P<0.001).In the FGR group,more neonates had 5-minute Apgar score≤7(7.9%(53/670)vs.3.9%(149/3780),P<0.001),with higher neonatal intensive care unit admission rate(48.1%(322/670)vs.23.3%(881/3781),P<0.001).More cases of HELLP syndrome occurred in the FGR group(6.9%(46/670)vs.3.2%(122/3781),P<0.001).Women with FGR had heavier 24-hour urinary protein excretion than those without FGR((3.9±3.7)g vs.(3.1±4.2)g,P=0.005).Conclusion:In pregnancies with hypertensive disorders,increased risks of FGR are associated with preterm birth,birth before 34 weeks,and a previous FGR history.FGR is related to higher occurrence of abnormal uterine artery Doppler and umbilical artery Doppler.When hypertensive disorders is complicated by FGR,there appears to be higher maternal morbidity including higher rate of HELLP syndrome,cesarean section,and heavier proteinuria,as well as worse neonatal outcomes.
