目的:分析免疫检查点抑制剂(ICIs)致严重皮肤不良事件(AE)的一般规律和特点,为临床安全用药提供参考。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方和维普数据库,检索时限自建库截至2022年5月9日,收集I...目的:分析免疫检查点抑制剂(ICIs)致严重皮肤不良事件(AE)的一般规律和特点,为临床安全用药提供参考。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方和维普数据库,检索时限自建库截至2022年5月9日,收集ICIs致严重皮肤AE的相关信息并进行统计分析。结果:共纳入15篇文献,收集病例3813例,其中84例发生严重皮肤AE。 PD-1抑制剂联合CTLA-4抑制剂治疗肿瘤的严重皮肤AE发生率(8.51%)显著高于各单药治疗的发生率;单药治疗中,帕博利珠单抗所致严重皮肤AE发生率最高(2.43%),伊匹木单抗次之(1.72%);肿瘤患者接受高剂量(10 mg·kg^(-1))伊匹木单抗治疗发生严重皮肤AE的概率高于低剂量治疗组;黑色素瘤患者的严重皮肤AE发生率(2.25%)明显高于其他类型肿瘤患者。结论:临床应警惕ICIs所致严重皮肤AE,以确保患者用药安全。展开更多
Plant height （PH） is one of the most important agronomic traits of rice, as it directly affects the lodging resistance and the high yield potential. Meanwhile, PH is often constrained by water supply over the entire...Plant height （PH） is one of the most important agronomic traits of rice, as it directly affects the lodging resistance and the high yield potential. Meanwhile, PH is often constrained by water supply over the entire growth period. In this study, a recombinant inbred line （RIL） derived from Xiaobaijingzi and Kongyu 131 strains grown under drought stress and with normal irrigation over 2 yr （2013 and 2014）, respectively （regarded as four environments）, was used to dissect the genetic basis of PH by developmental dynamics QTL analysis combined with QTL^environment interactions. QTLs with net effects excluding the accumulated effects were detected to explore the relationship between genexgene interactions and genexenvironment interactions in specific growth period. A total of 26 additive QTLs （A-QTLs） and 37 epistatic QTLs （E-QTLs） associated with PH were detected by unconditional and conditional mapping over seven growth periods, qPH-2-3, qPH-4-3, qPH-6-1, qPH-7-1, and qPH-12-5 could be detected by both unconditional and conditional analyses, qPH-4-3 and qPH-7-5 were detected in four stages （periods） to be sequentially expressed QTLs controlling PH continuous variation. QTLs with additive effects （A-QTLs） were mostly expressed in the period $3iS2 （the time interval from stages 2 to 3）, and QTLxenvironment interactions performed actively in the first three stages （periods） which could be an important developmental period for rice to undergo external morphogenesis during drought stress. Several QTLs showed high adaptability for drought stress and many QTLs were closely related to the environments such as qPH-3-5, qPH-2-2 and qPH-6-1. 72.5% of the QTLs with a and aa effects detected by conditional analysis were under drought stress, and the PVE of QTLs detected by conditional analysis under drought stress were also much higher than that under normal irrigation. We infer that environments would influence the detection results and sequential expression of genes was highly influenced by environments as well. Many QTLs （qPH-1-2, qPH-3-5, qPH-4-1, qPH-2-3） coincident with previously identified drought resistance genes. The result of this study is helpful to elucidating the genetic mechanism and regulatory network underlying the development of PH in rice and providing references to marker assisted selection.展开更多
Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type cases.Therefore,appropriate,effective,and safe use of biologic drugs has d...Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type cases.Therefore,appropriate,effective,and safe use of biologic drugs has drawn attention from dermatologists.For this purpose,Chinese experts majoring in psoriasis analyzed domestic and international research data,summarized current clinical experiences,investigated features of Chinese patients with psoriasis,and finally formulated the present consensus,which provides detailed guidances to clinicians in terms of the principles and methods of the application of biologics,the efficacy and safety profile,patient screening and monitoring,main adverse events and corresponding solutions,and precautions for special patient populations.展开更多
基金supported by the National Key Technologies R&D Program of China during the 12th Five-Year Plan period (2013BAD20B04)
文摘Plant height （PH） is one of the most important agronomic traits of rice, as it directly affects the lodging resistance and the high yield potential. Meanwhile, PH is often constrained by water supply over the entire growth period. In this study, a recombinant inbred line （RIL） derived from Xiaobaijingzi and Kongyu 131 strains grown under drought stress and with normal irrigation over 2 yr （2013 and 2014）, respectively （regarded as four environments）, was used to dissect the genetic basis of PH by developmental dynamics QTL analysis combined with QTL^environment interactions. QTLs with net effects excluding the accumulated effects were detected to explore the relationship between genexgene interactions and genexenvironment interactions in specific growth period. A total of 26 additive QTLs （A-QTLs） and 37 epistatic QTLs （E-QTLs） associated with PH were detected by unconditional and conditional mapping over seven growth periods, qPH-2-3, qPH-4-3, qPH-6-1, qPH-7-1, and qPH-12-5 could be detected by both unconditional and conditional analyses, qPH-4-3 and qPH-7-5 were detected in four stages （periods） to be sequentially expressed QTLs controlling PH continuous variation. QTLs with additive effects （A-QTLs） were mostly expressed in the period $3iS2 （the time interval from stages 2 to 3）, and QTLxenvironment interactions performed actively in the first three stages （periods） which could be an important developmental period for rice to undergo external morphogenesis during drought stress. Several QTLs showed high adaptability for drought stress and many QTLs were closely related to the environments such as qPH-3-5, qPH-2-2 and qPH-6-1. 72.5% of the QTLs with a and aa effects detected by conditional analysis were under drought stress, and the PVE of QTLs detected by conditional analysis under drought stress were also much higher than that under normal irrigation. We infer that environments would influence the detection results and sequential expression of genes was highly influenced by environments as well. Many QTLs （qPH-1-2, qPH-3-5, qPH-4-1, qPH-2-3） coincident with previously identified drought resistance genes. The result of this study is helpful to elucidating the genetic mechanism and regulatory network underlying the development of PH in rice and providing references to marker assisted selection.
文摘Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type cases.Therefore,appropriate,effective,and safe use of biologic drugs has drawn attention from dermatologists.For this purpose,Chinese experts majoring in psoriasis analyzed domestic and international research data,summarized current clinical experiences,investigated features of Chinese patients with psoriasis,and finally formulated the present consensus,which provides detailed guidances to clinicians in terms of the principles and methods of the application of biologics,the efficacy and safety profile,patient screening and monitoring,main adverse events and corresponding solutions,and precautions for special patient populations.
