Staphylococcus aureus(S.aureus) is one of the most common human pathogens,causing a wide range of afflictions from minor infections of the skin to serious wound infections,bacteraemia,pneumonia and endocarditis. Methi...Staphylococcus aureus(S.aureus) is one of the most common human pathogens,causing a wide range of afflictions from minor infections of the skin to serious wound infections,bacteraemia,pneumonia and endocarditis. Methicillin,the first semisynthetic derivative of penicillin,was a new hope to treat penicillin resistant 5.aureus in the early 1960s.Nevertheless,only one year after its introduction,the first methicillin-resistant 5.aureus (MRSA) strains were detected.There is no golden rule in the control of MRSA.Nevertheless,using surveillance cultures of patients and healthcare personnel,strictly enforced contact precautions,and judicious use of broad-spectrum antibiotics have helped several countries,including Finland,Denmark,and the Netherlands to keep MRSA at a very low level.Conversely,countries including China,Japan,US,Italy,Greece,UK, where stringent counter-measure were not able to be installed,MRSA have become hyper-endemic.Control of MRSA in those countries were obliged to concentrate available resources to prevent MRSA infections only at patients at high risk of serious morbidity and mortality.展开更多
文摘Staphylococcus aureus(S.aureus) is one of the most common human pathogens,causing a wide range of afflictions from minor infections of the skin to serious wound infections,bacteraemia,pneumonia and endocarditis. Methicillin,the first semisynthetic derivative of penicillin,was a new hope to treat penicillin resistant 5.aureus in the early 1960s.Nevertheless,only one year after its introduction,the first methicillin-resistant 5.aureus (MRSA) strains were detected.There is no golden rule in the control of MRSA.Nevertheless,using surveillance cultures of patients and healthcare personnel,strictly enforced contact precautions,and judicious use of broad-spectrum antibiotics have helped several countries,including Finland,Denmark,and the Netherlands to keep MRSA at a very low level.Conversely,countries including China,Japan,US,Italy,Greece,UK, where stringent counter-measure were not able to be installed,MRSA have become hyper-endemic.Control of MRSA in those countries were obliged to concentrate available resources to prevent MRSA infections only at patients at high risk of serious morbidity and mortality.
