Construction of the Core of Pseudolaric Acid A and Mechanistic Studies on Intramolecular [4+3] Cycloaddition

This paper describes the construction of hemiacetal 2, the core of pseudolaric acid A via oxidative cleavage of acetonide 6 or 7 and enolization-hemiacetalization of aldehyde 8. A plausible general mechanism for thc intramolecular [4+3] cycloaddition of sulfoxide 4 to adduct 3 is suggested.

Studies on the Total Synthesis of Pseudolaric Acid A Stereocontrolled Synthesis of the Seven-membered Lactone

The lactone 16 was obtained stereo- and regioselectively by a reaction sequence of 9 steps in 21% overall yield.

An Efficient Cleavage of 1,3-Dioxolane Using ZnCl_2/THF/H_2O

A new. mild and efficient method for the cleavage of 1,3-dioxolane is reported.

Stereoselective Synthesis of (6R)-6-(5-Methyl-2-furyl)-2-oxocyclohexanecarboxyl-10', 2'-Sultam

Stereoselective synthesis of sultam 8 was reported. The overall yield in a scLluence of 4steps is 27.5%.