泥石流灾害是较常见且频发的地质灾害之一,常造成大量人员伤亡和财产损失。以空心寨沟泥石流为例,采用地面调查、室内试验、现场试验、定性分析及定量评价相结合的方法,分析了泥石流的基本特征,确定了相关的动力学参数,揭示了泥石流的...泥石流灾害是较常见且频发的地质灾害之一,常造成大量人员伤亡和财产损失。以空心寨沟泥石流为例,采用地面调查、室内试验、现场试验、定性分析及定量评价相结合的方法,分析了泥石流的基本特征,确定了相关的动力学参数,揭示了泥石流的形成规律及灾变机制。研究结果表明,空心寨沟泥石流为中频—暴雨—崩塌—滑坡—沟谷型黏性泥石流,目前处于壮年期,计算暴雨频率在P=5%条件下空心寨沟泥石流的平均流速为6.91 m/s,峰值流量达142.58 m 3/s,其中一次泥石流冲出流体总量为2.9104×104 m 3,冲出固体总量为1.5875×104 m 3。研究结果为制定空心寨沟泥石流灾害防治措施提供了重要依据。展开更多
A continuous Ordovician-Silurian boundary section from the upper Wufeng Formation through the Kuanyinchiao Formation to the lower Lungmachi Formation has been carefully measured and collected at Shuanghe of Changning,...A continuous Ordovician-Silurian boundary section from the upper Wufeng Formation through the Kuanyinchiao Formation to the lower Lungmachi Formation has been carefully measured and collected at Shuanghe of Changning, southern Sichuan Province. For the first time, the temporal changes of α- and β-diversities of the Hirnantia fauna have been discussed in great detail. The general trend of brachiopod diversity change, increasing upward, is consistent with the regional trend of the Yangtze Platform, which had been controlled by both intrinsic and extrinsic factors. However, the sudden drop of diversity for a short period in the upper Kuanyinchiao Formation might have been controlled by environmental factors rather than normal faunal turnover. Synecological analysis using numerical methods recognizes two brachiopod-dominated associations of the Hirnantia fauna, the Dalmanella-Kinnella Association and the Mirorthis Association, both living in an offshore, deeper water environment corresponding to BA3-upper BA4, particularly lower BA3.展开更多
There is an increasing interest in understanding how three-dimensional(3D)organization of the genome is regulated.Different strategies have been employed to identify genome-wide chromatin interactions.However,due to c...There is an increasing interest in understanding how three-dimensional(3D)organization of the genome is regulated.Different strategies have been employed to identify genome-wide chromatin interactions.However,due to current limitations in resolving genomic contacts,visualization and validation of these genomic loci with sub-kilobase resolution remain unsolved to date.Here,we describe Tn5 transposase-based Fluorescencein situhybridization(Tn5-FISH),a PCR-based,cost-effective imaging method,which can co-localize the genomic loci with sub-kilobase resolution,dissect genome architecture,and verify chromatin interactions detected by chromatin configuration capture(3C)-derived methods.To validate this method,short-range interactions in keratin-encoding gene(KRT)locus in topologically associated domain(TAD)were imaged by triple-color Tn5-FISH,indicating that Tn5-FISH is very useful to verify short-range chromatin interactions inside the contact domain and TAD.Therefore,Tn5-FISH can be a powerful molecular tool for the clinical detection of cytogenetic changes in numerous genetic diseases such as cancers.展开更多
文摘泥石流灾害是较常见且频发的地质灾害之一,常造成大量人员伤亡和财产损失。以空心寨沟泥石流为例,采用地面调查、室内试验、现场试验、定性分析及定量评价相结合的方法,分析了泥石流的基本特征,确定了相关的动力学参数,揭示了泥石流的形成规律及灾变机制。研究结果表明,空心寨沟泥石流为中频—暴雨—崩塌—滑坡—沟谷型黏性泥石流,目前处于壮年期,计算暴雨频率在P=5%条件下空心寨沟泥石流的平均流速为6.91 m/s,峰值流量达142.58 m 3/s,其中一次泥石流冲出流体总量为2.9104×104 m 3,冲出固体总量为1.5875×104 m 3。研究结果为制定空心寨沟泥石流灾害防治措施提供了重要依据。
基金supported by the Chinese Academy of Sciences (KZCX2-YW-Q05-01)the Ministry of Science and Technology of China (2006FY120300-5)the National Natural Science Foundation of China (40825006, 40972020), and the State Key Laboratory of Palaeobiology and Stratigraphy of NIGPAS
文摘A continuous Ordovician-Silurian boundary section from the upper Wufeng Formation through the Kuanyinchiao Formation to the lower Lungmachi Formation has been carefully measured and collected at Shuanghe of Changning, southern Sichuan Province. For the first time, the temporal changes of α- and β-diversities of the Hirnantia fauna have been discussed in great detail. The general trend of brachiopod diversity change, increasing upward, is consistent with the regional trend of the Yangtze Platform, which had been controlled by both intrinsic and extrinsic factors. However, the sudden drop of diversity for a short period in the upper Kuanyinchiao Formation might have been controlled by environmental factors rather than normal faunal turnover. Synecological analysis using numerical methods recognizes two brachiopod-dominated associations of the Hirnantia fauna, the Dalmanella-Kinnella Association and the Mirorthis Association, both living in an offshore, deeper water environment corresponding to BA3-upper BA4, particularly lower BA3.
基金This work was supported in part by the State Key Research Development Program of China(2017YFA0505503)the National Natural Science Foundation of China(81890991 and 31671383)+4 种基金Beijing Advanced Innovation Center for Structural Bio logy,Tsinghua University(100300001)the fund from Foshan-Tsinghua Innovation Special Fund(FTISF,2019THFS0141)to J.G.,the National Natural Science Foundation of China(31871444)the program for Guangdong Introducing Innovative and Entrepreneurial Teams(2016ZT06S029)to J.W.Australia China Science and Research Fund Joint Research Centre for POCT(ACSRF65827)Shenzhen Science and Technology Program(KQTD 20170810110913065)to D.J.
文摘There is an increasing interest in understanding how three-dimensional(3D)organization of the genome is regulated.Different strategies have been employed to identify genome-wide chromatin interactions.However,due to current limitations in resolving genomic contacts,visualization and validation of these genomic loci with sub-kilobase resolution remain unsolved to date.Here,we describe Tn5 transposase-based Fluorescencein situhybridization(Tn5-FISH),a PCR-based,cost-effective imaging method,which can co-localize the genomic loci with sub-kilobase resolution,dissect genome architecture,and verify chromatin interactions detected by chromatin configuration capture(3C)-derived methods.To validate this method,short-range interactions in keratin-encoding gene(KRT)locus in topologically associated domain(TAD)were imaged by triple-color Tn5-FISH,indicating that Tn5-FISH is very useful to verify short-range chromatin interactions inside the contact domain and TAD.Therefore,Tn5-FISH can be a powerful molecular tool for the clinical detection of cytogenetic changes in numerous genetic diseases such as cancers.
