Objective：To observe the clinical effects of tuina plus Western medication for functional dyspepsia （FD） due to liver qi stagnation and spleen deficiency.Methods：A total of 72 patients in conformity with the inclu...Objective：To observe the clinical effects of tuina plus Western medication for functional dyspepsia （FD） due to liver qi stagnation and spleen deficiency.Methods：A total of 72 patients in conformity with the inclusion criteria of FD were randomly divided into an observation group and a control group based upon the random number table,36 cases in each group.The control group was treated with mosapride citrate dispersible tablets,and the observation group was treated with the same tablets plus tuina.Before the treatment and 4 weeks after the treatment,the clinical symptoms,quality of life （QOL） and depression severity were observed by the scale,and were followed up two months later after the treatment for assessment of the clinical effects.Results：After the treatment and at the follow-up,the symptom scores of FD and the sores of Hamilton depression rating scale （HAMD） in both groups decreased,and the scores in Chinese version of quality of life questionnaire for functional digestive disorders （Chin-FDDQL） increased,with statistically significant differences in comparison with the same group before the treatment （all P〈0.05）.In comparison between the two groups at the same time point after the treatment,the scores of FD symptoms,HAMD and Chin-FDDQL were improved better in the observation group than those in the control group,with statistically significant differences （all P〈0.05）.The total effective rates at the follow-up were 91.7% in the observation group and 75.0% in the control group,without statistical difference between the two groups （P〉0.05）.The rate of clinical cure and remarkable effect was 66.7% in the observation group,higher than 41.7% in the control group,it is higher in the observation group than that in the control group,with a statistically significant difference between the two groups （P〈0.05）.Conclusion：Tuina plus Western medication is precise in the therapeutic effects for FD due to liver qi stagnation and spleen deficiency and can effectively relieve clinical symptoms,elevate the QOL and alleviate depression severity of the patients.Moreover,it＇s better than the treatment by Western medication alone in the long-term therapeutic effects.展开更多
Objective:To compare and explore the effects of needling acupoints at different nerve segments on the oxytocin(OT)neurons in the paraventricular nucleus of hypothalamus(PVN)and the intragastric pressure,and discuss th...Objective:To compare and explore the effects of needling acupoints at different nerve segments on the oxytocin(OT)neurons in the paraventricular nucleus of hypothalamus(PVN)and the intragastric pressure,and discuss the possible mechanisms.Methods:Thirty-two healthy adult Sprague-Dawley(SD)rats were numbered and divided into 4 groups according to the random number table,a Zusanli(ST 36)group,a Neiguan(PC 6)group,a Weishu(BL 21)group and a control group,with 8 rats in each group.Except the control group,rats in the other three groups received acupuncture at the corresponding acupoints.To observe the differences in double-labeled OT neurons and c-fos neurons of the hypothalamic PVN and the intragastric pressure after acupuncture among the three groups of needling acupoints at different nerve segments.Results:Compared with the control group,the numbers of double-labeled cells in the PVN of the Zusanli(ST 36)group and the Neiguan(PC 6)group decreased significantly,while the intragastric pressure increased significantly(all P<0.05),and the inter-group differences were statistically significant(P<0.05).The intragastric pressure in the Weishu(BL 21)group decreased significantly,and the inter-group difference was statistically significant(P<0.05).Compared with the Weishu(BL 21)group,the numbers of OT/c-fos double-labeled cells in PVN of the Zusanli(ST 36)group and the Neiguan(PC 6)group decreased significantly,and the intragastric pressure increased significantly,the inter-group differences were statistically significant(all P<0.01).Conclusion:Acupoints at different nerve segments have different regulation effects on intragastric pressure.The difference may be related to the different nerve conduction pathways by acupoints at different nerve segments in regulating the intragastric pressure.The PVN may be one common integration center for the regulation of gastric function in the three acupoints[Zusanli(ST 36),Neiguan(PC 6)and Weishu(BL 21)]at different nerve segments.展开更多
文摘Objective：To observe the clinical effects of tuina plus Western medication for functional dyspepsia （FD） due to liver qi stagnation and spleen deficiency.Methods：A total of 72 patients in conformity with the inclusion criteria of FD were randomly divided into an observation group and a control group based upon the random number table,36 cases in each group.The control group was treated with mosapride citrate dispersible tablets,and the observation group was treated with the same tablets plus tuina.Before the treatment and 4 weeks after the treatment,the clinical symptoms,quality of life （QOL） and depression severity were observed by the scale,and were followed up two months later after the treatment for assessment of the clinical effects.Results：After the treatment and at the follow-up,the symptom scores of FD and the sores of Hamilton depression rating scale （HAMD） in both groups decreased,and the scores in Chinese version of quality of life questionnaire for functional digestive disorders （Chin-FDDQL） increased,with statistically significant differences in comparison with the same group before the treatment （all P〈0.05）.In comparison between the two groups at the same time point after the treatment,the scores of FD symptoms,HAMD and Chin-FDDQL were improved better in the observation group than those in the control group,with statistically significant differences （all P〈0.05）.The total effective rates at the follow-up were 91.7% in the observation group and 75.0% in the control group,without statistical difference between the two groups （P〉0.05）.The rate of clinical cure and remarkable effect was 66.7% in the observation group,higher than 41.7% in the control group,it is higher in the observation group than that in the control group,with a statistically significant difference between the two groups （P〈0.05）.Conclusion：Tuina plus Western medication is precise in the therapeutic effects for FD due to liver qi stagnation and spleen deficiency and can effectively relieve clinical symptoms,elevate the QOL and alleviate depression severity of the patients.Moreover,it＇s better than the treatment by Western medication alone in the long-term therapeutic effects.
文摘Objective:To compare and explore the effects of needling acupoints at different nerve segments on the oxytocin(OT)neurons in the paraventricular nucleus of hypothalamus(PVN)and the intragastric pressure,and discuss the possible mechanisms.Methods:Thirty-two healthy adult Sprague-Dawley(SD)rats were numbered and divided into 4 groups according to the random number table,a Zusanli(ST 36)group,a Neiguan(PC 6)group,a Weishu(BL 21)group and a control group,with 8 rats in each group.Except the control group,rats in the other three groups received acupuncture at the corresponding acupoints.To observe the differences in double-labeled OT neurons and c-fos neurons of the hypothalamic PVN and the intragastric pressure after acupuncture among the three groups of needling acupoints at different nerve segments.Results:Compared with the control group,the numbers of double-labeled cells in the PVN of the Zusanli(ST 36)group and the Neiguan(PC 6)group decreased significantly,while the intragastric pressure increased significantly(all P<0.05),and the inter-group differences were statistically significant(P<0.05).The intragastric pressure in the Weishu(BL 21)group decreased significantly,and the inter-group difference was statistically significant(P<0.05).Compared with the Weishu(BL 21)group,the numbers of OT/c-fos double-labeled cells in PVN of the Zusanli(ST 36)group and the Neiguan(PC 6)group decreased significantly,and the intragastric pressure increased significantly,the inter-group differences were statistically significant(all P<0.01).Conclusion:Acupoints at different nerve segments have different regulation effects on intragastric pressure.The difference may be related to the different nerve conduction pathways by acupoints at different nerve segments in regulating the intragastric pressure.The PVN may be one common integration center for the regulation of gastric function in the three acupoints[Zusanli(ST 36),Neiguan(PC 6)and Weishu(BL 21)]at different nerve segments.
