Objective:To explore the potential mechanism of action of quercetin in the treatment of diarrhea irritable bowel syndrome(IBS-D).Methods:The potential targets of quercetin were obtained from the TCMSP,SwissTar-getPred...Objective:To explore the potential mechanism of action of quercetin in the treatment of diarrhea irritable bowel syndrome(IBS-D).Methods:The potential targets of quercetin were obtained from the TCMSP,SwissTar-getPrediction,and BATMAN-TCM databases.The targets of IBS-D were obtained by searching the GeneCards database with"diarrhea irritable bowel syndrome"as the keyword,and the targets of quercetin and IBS-D were intersected.The PPI network was constructed by Cytoscape 3.7.1 software.The intersected targets were imported into the DAVID database for GO functional analysis and KEGG pathway enrichment analysis.The binding ability of quercetin to the core targets was observed using molecular docking.Based on this,we established an IBS-D rat model,administered quercetin for intervention,and experimentally validated the network pharmacology prediction results by HE staining and ELISA assay.Results:Network pharmacology analysis showed that TP53,TNF-α,AKT1,VEGF-A,IL-6 factors and MAPK,PI3K-Akt signaling pathway as the core targets and pathways of quercetin for the treatment of IBS-D.The results of animal experiments revealed that quercetin could inhibit the secretion of TP53,TNF-α,AKT1,VEGF-A,IL-1βand IL-6,reduce the inflammatory response and improve IBS-D.Conclusion:Quercetin could protect colon tissue by regulating the expression of TP53,TNF-α,AKT1,VEGF-A,IL-1βand IL-6,thereby treating IBS-D.展开更多
An MW6.6 earthquake occurred in eastern Hokkaido,Japan on September 6th,2018.Based on the pre-earthquake image from Google Earth and the post-earthquake image from high resolution(3 m)planet satellite,we manually inte...An MW6.6 earthquake occurred in eastern Hokkaido,Japan on September 6th,2018.Based on the pre-earthquake image from Google Earth and the post-earthquake image from high resolution(3 m)planet satellite,we manually interpret 9293 coseismic landslides and select 7 influencing factors of seismic landslide,such as elevation,slope,slope direction,road distance,flow distance,peak ground acceleration(PGA)and lithology.Then,9293 landslide points are randomly divided into training samples and validation samples with a proportion of 7:3.In detail,the training sample has 6505 landslide points and the validation sample has 2788 landslide points.The hazard risk assessment of seismic landslide is conducted by using the information value method and the study area is further divided into five risk grades,including very low risk area,low risk area,moderate risk area high risk area and very high risk area.The results show that there are 7576 landslides in high risk area and very high risk area,accounting for81.52%of the total landslide number,and the landslide area is 22.93 km^2,accounting for 74.35%of the total area.The hazard zoning is in high accordance with the actual situation.The evaluation results are tested by using the curve of cumulative percentage of hazardous area and cumulative percentage of landslides number.The results show that the success rate of the information value method is 78.50%and the prediction rate is 78.43%.The evaluation results are satisfactory,indicating that the hazard risk assessment results based on information value method may provide scientific reference for landslide hazard risk assessment as well as the disaster prevention and mitigation in the study area.展开更多
A series of spinel-type Mg_(0.25-x)Al_(2.57)O_(3.79)N_(0.21):xMn^(2+)(MgAlON:xMn^(2+))phosphors were synthesized by the solid-state reaction route.The transparent ceramic phosphors were fabricated by pressureless sint...A series of spinel-type Mg_(0.25-x)Al_(2.57)O_(3.79)N_(0.21):xMn^(2+)(MgAlON:xMn^(2+))phosphors were synthesized by the solid-state reaction route.The transparent ceramic phosphors were fabricated by pressureless sintering followed by hot-isostatic pressing(HIP).The crystal structure,luminescence and mechanical properties of the samples were systematically investigated.The transparent ceramic phosphors with tetrahedrally coordinated Mn^(2+)show strong green emission centered around 515 nm under blue light excitation.As the Mn^(2+)concentration increases,the crystal lattice expands slightly,resulting in a variation of crystal field and a slight red-shift of green emission peak.Six weak absorption peaks in the transmittance spectra originate from the spin-forbidden ^(4)T_(1)(^(4)G)→^(6)A_(1) transition of Mn^(2+).The decay time was found to decrease from 5.66 to 5.16 ms with the Mn^(2+)concentration.The present study contributes to the systematic understanding of crystal structure and properties of MgAlON:xMn^(2+)green-emitting transparent ceramic phosphor which has a potential application in high-power light-emitting diodes.展开更多
基金National Natural Science Foundation of China(No.82160890)Guangxi Health Appropriate Technology Development and Application Project(No.GZSY23-21)+1 种基金Graduate Education Innovation Project,Guangxi University of Traditional Chinese Medicine(No.YCSW2023383)Research Program of Guangxi University of Traditional Chinese Medicine(No.2019MS016)。
文摘Objective:To explore the potential mechanism of action of quercetin in the treatment of diarrhea irritable bowel syndrome(IBS-D).Methods:The potential targets of quercetin were obtained from the TCMSP,SwissTar-getPrediction,and BATMAN-TCM databases.The targets of IBS-D were obtained by searching the GeneCards database with"diarrhea irritable bowel syndrome"as the keyword,and the targets of quercetin and IBS-D were intersected.The PPI network was constructed by Cytoscape 3.7.1 software.The intersected targets were imported into the DAVID database for GO functional analysis and KEGG pathway enrichment analysis.The binding ability of quercetin to the core targets was observed using molecular docking.Based on this,we established an IBS-D rat model,administered quercetin for intervention,and experimentally validated the network pharmacology prediction results by HE staining and ELISA assay.Results:Network pharmacology analysis showed that TP53,TNF-α,AKT1,VEGF-A,IL-6 factors and MAPK,PI3K-Akt signaling pathway as the core targets and pathways of quercetin for the treatment of IBS-D.The results of animal experiments revealed that quercetin could inhibit the secretion of TP53,TNF-α,AKT1,VEGF-A,IL-1βand IL-6,reduce the inflammatory response and improve IBS-D.Conclusion:Quercetin could protect colon tissue by regulating the expression of TP53,TNF-α,AKT1,VEGF-A,IL-1βand IL-6,thereby treating IBS-D.
基金supported by the BasicScientific Fund of the Institute of Geology,China Earthquake Administration(IGCEA1604)。
文摘An MW6.6 earthquake occurred in eastern Hokkaido,Japan on September 6th,2018.Based on the pre-earthquake image from Google Earth and the post-earthquake image from high resolution(3 m)planet satellite,we manually interpret 9293 coseismic landslides and select 7 influencing factors of seismic landslide,such as elevation,slope,slope direction,road distance,flow distance,peak ground acceleration(PGA)and lithology.Then,9293 landslide points are randomly divided into training samples and validation samples with a proportion of 7:3.In detail,the training sample has 6505 landslide points and the validation sample has 2788 landslide points.The hazard risk assessment of seismic landslide is conducted by using the information value method and the study area is further divided into five risk grades,including very low risk area,low risk area,moderate risk area high risk area and very high risk area.The results show that there are 7576 landslides in high risk area and very high risk area,accounting for81.52%of the total landslide number,and the landslide area is 22.93 km^2,accounting for 74.35%of the total area.The hazard zoning is in high accordance with the actual situation.The evaluation results are tested by using the curve of cumulative percentage of hazardous area and cumulative percentage of landslides number.The results show that the success rate of the information value method is 78.50%and the prediction rate is 78.43%.The evaluation results are satisfactory,indicating that the hazard risk assessment results based on information value method may provide scientific reference for landslide hazard risk assessment as well as the disaster prevention and mitigation in the study area.
基金Funded by the National Natural Science Foundation of China(No.52272072)the Independent Innovation Projects of the Hubei Longzhong Laboratory(No.2022ZZ-13)。
文摘A series of spinel-type Mg_(0.25-x)Al_(2.57)O_(3.79)N_(0.21):xMn^(2+)(MgAlON:xMn^(2+))phosphors were synthesized by the solid-state reaction route.The transparent ceramic phosphors were fabricated by pressureless sintering followed by hot-isostatic pressing(HIP).The crystal structure,luminescence and mechanical properties of the samples were systematically investigated.The transparent ceramic phosphors with tetrahedrally coordinated Mn^(2+)show strong green emission centered around 515 nm under blue light excitation.As the Mn^(2+)concentration increases,the crystal lattice expands slightly,resulting in a variation of crystal field and a slight red-shift of green emission peak.Six weak absorption peaks in the transmittance spectra originate from the spin-forbidden ^(4)T_(1)(^(4)G)→^(6)A_(1) transition of Mn^(2+).The decay time was found to decrease from 5.66 to 5.16 ms with the Mn^(2+)concentration.The present study contributes to the systematic understanding of crystal structure and properties of MgAlON:xMn^(2+)green-emitting transparent ceramic phosphor which has a potential application in high-power light-emitting diodes.
