A high pressure oil pump has the advantages of compact structure, high working pressure, and it canstill maintain a high efficiency when it is working, so it is very important to analyze its structural strength. A hig...A high pressure oil pump has the advantages of compact structure, high working pressure, and it canstill maintain a high efficiency when it is working, so it is very important to analyze its structural strength. A high-pressure diesel monomer pump is the research object, it is using the finite element software Hypermesh to do thepretreatment of the finite element model, then using Fluent software to analysis the fluid finite element modelwhen it pumped oil to obtain the distribution of oil pressure in the process of pumping oil. And then it is usingAbaqus software to analyze the strength of the related components of the model through mapping oil pressure at thetime of the maximum oil pressure distribution to the model by the structure finite element interpolation, so it canobtain the stress distribution of each component. According to this coupling method to analyze the structuralstrength of high pressure oil pump, it provided the better guidance and reference for the design and optimization ofhigh pressure oil pump.展开更多
The collective behaviors of two coupled harmonic oscillators with dichotomous fluctuating frequency are investigated,including stability, synchronization, and stochastic resonance(SR). First, the synchronization condi...The collective behaviors of two coupled harmonic oscillators with dichotomous fluctuating frequency are investigated,including stability, synchronization, and stochastic resonance(SR). First, the synchronization condition of the system is obtained. When this condition is satisfied, the mean-field behavior is consistent with any single particle behavior in the system. On this basis, the stability condition and the exact steady-state solution of the system are derived. Comparative analysis shows that, the stability condition is stronger than the synchronization condition, that is to say, when the stability condition is satisfied, the system is both synchronous and stable. Simulation analysis indicates that increasing the coupling strength will reduce the synchronization time. In weak coupling region, there is an optimal coupling strength that maximizes the output amplitude gain(OAG), thus the coupling-induced SR behavior occurs. In strong coupling region, the two particles are bounded as a whole, so that the coupling effect gradually disappears.展开更多
Ecological restoration refers to the containment of soil erosion,restoration of water conservation,climate regulation,maintenance of ecological functions of biodiversity,and improvement of ecological environment and l...Ecological restoration refers to the containment of soil erosion,restoration of water conservation,climate regulation,maintenance of ecological functions of biodiversity,and improvement of ecological environment and landscape pattern based on self-repairing capacity of the nature and combined with appropriate artificial measures. Since the natural restoration process of karst desertification mountain is very long,it needs to be supplemented by artificial vegetation restoration. This paper introduced the ecological restoration technologies implemented in karst rocky desertification mountains in Xixiu District,Anshun City of Guizhou Province,and also introduced the afforestation tending management measures. It assessed the ecological benefits of the ecological restoration project from five aspects: mountain community characteristics,vegetation coverage,species diversity,afforestation survival rate and landscape effect.展开更多
Male pseudohermaphroditism is a rare disorders of sex development(DSD)that is manifested by a female-like appearance or incompletely differentiated external genitalia in an individual with a Y chromosome.In this paper...Male pseudohermaphroditism is a rare disorders of sex development(DSD)that is manifested by a female-like appearance or incompletely differentiated external genitalia in an individual with a Y chromosome.In this paper,we report our investigation of the case of a 33-year-old Chinese female who was diagnosed with a malignant mixed germ-cell tumor of the ovary.To confirm the sex of the female,we utilized genetic approaches to detect amelogenin and Y-STR loci.Y chromosome microdeletion was performed to identify existing deletions in the AZF regions and SRY.Chromosome karyotyping and whole-exome sequencing(WES)were then applied to reveal the deletion of sex chromosome segments and pathogenic variations in DNA sequences.Using DNA-STR genotyping,we detected both AMEL-X and AMEL-Y fragments.We also found haplotype Y-STR loci and detected all alleles.Furthermore,no microdeletion was detected in the AZF regions and SRY.The chromosome karyotyping was 46,XY.WES revealed a transversion mutation of 58T→C in the androgen receptor exon 1,which could be the pathogenic variant in this case of abnormal sexual development.Sex determination in forensic DNA typing is based on the amelogenin system.It is important that forensic biologists should master various genetic approaches to overcome the issue of gender ambiguity caused by DSDs.展开更多
Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue.Through interactions between chemokines and their receptors,various immune cell subsets are recruited into the tumor...Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue.Through interactions between chemokines and their receptors,various immune cell subsets are recruited into the tumor microenvironment which is the primary location for tumor cells interacting with responding host cells.In recent decades,a large volume of studies have revealed chemokines'role in the tumor microenviron-ment in regulating tumor growth,invasion,and/or metastasis as well as tumor immune response;however,their molecular mechanisms are not well understood.Recently,increasing evidence has reported the import-ance of the CXCL13-CXCR5 axis in the tumor microenvironment of vanious human malignancies.Thus,in this review,we will focus on the CXCL13-CXCR5 axis and elaborate on the expression patterns,regulating and cor-responding regulatory mechanisms as well as clinical values in a wide range of human cancers.展开更多
文摘A high pressure oil pump has the advantages of compact structure, high working pressure, and it canstill maintain a high efficiency when it is working, so it is very important to analyze its structural strength. A high-pressure diesel monomer pump is the research object, it is using the finite element software Hypermesh to do thepretreatment of the finite element model, then using Fluent software to analysis the fluid finite element modelwhen it pumped oil to obtain the distribution of oil pressure in the process of pumping oil. And then it is usingAbaqus software to analyze the strength of the related components of the model through mapping oil pressure at thetime of the maximum oil pressure distribution to the model by the structure finite element interpolation, so it canobtain the stress distribution of each component. According to this coupling method to analyze the structuralstrength of high pressure oil pump, it provided the better guidance and reference for the design and optimization ofhigh pressure oil pump.
基金supported by the National Natural Science Foundation of China for the Youth (Grant Nos. 11501385 and 11801385)。
文摘The collective behaviors of two coupled harmonic oscillators with dichotomous fluctuating frequency are investigated,including stability, synchronization, and stochastic resonance(SR). First, the synchronization condition of the system is obtained. When this condition is satisfied, the mean-field behavior is consistent with any single particle behavior in the system. On this basis, the stability condition and the exact steady-state solution of the system are derived. Comparative analysis shows that, the stability condition is stronger than the synchronization condition, that is to say, when the stability condition is satisfied, the system is both synchronous and stable. Simulation analysis indicates that increasing the coupling strength will reduce the synchronization time. In weak coupling region, there is an optimal coupling strength that maximizes the output amplitude gain(OAG), thus the coupling-induced SR behavior occurs. In strong coupling region, the two particles are bounded as a whole, so that the coupling effect gradually disappears.
基金Supported by the Construction Science and Technology Plan Program of Chongqing "Study on Landscape and Ecological Restoration Technology for Karst Rocky Desertification Landforms"(2015-1-19)
文摘Ecological restoration refers to the containment of soil erosion,restoration of water conservation,climate regulation,maintenance of ecological functions of biodiversity,and improvement of ecological environment and landscape pattern based on self-repairing capacity of the nature and combined with appropriate artificial measures. Since the natural restoration process of karst desertification mountain is very long,it needs to be supplemented by artificial vegetation restoration. This paper introduced the ecological restoration technologies implemented in karst rocky desertification mountains in Xixiu District,Anshun City of Guizhou Province,and also introduced the afforestation tending management measures. It assessed the ecological benefits of the ecological restoration project from five aspects: mountain community characteristics,vegetation coverage,species diversity,afforestation survival rate and landscape effect.
基金the Project of Cultivating Young Talent in Fujian Provincial Health Commission(2020GGA004)Fujian Natural Science Foundation of China(Grant/Award Number:2021J01354).
文摘Male pseudohermaphroditism is a rare disorders of sex development(DSD)that is manifested by a female-like appearance or incompletely differentiated external genitalia in an individual with a Y chromosome.In this paper,we report our investigation of the case of a 33-year-old Chinese female who was diagnosed with a malignant mixed germ-cell tumor of the ovary.To confirm the sex of the female,we utilized genetic approaches to detect amelogenin and Y-STR loci.Y chromosome microdeletion was performed to identify existing deletions in the AZF regions and SRY.Chromosome karyotyping and whole-exome sequencing(WES)were then applied to reveal the deletion of sex chromosome segments and pathogenic variations in DNA sequences.Using DNA-STR genotyping,we detected both AMEL-X and AMEL-Y fragments.We also found haplotype Y-STR loci and detected all alleles.Furthermore,no microdeletion was detected in the AZF regions and SRY.The chromosome karyotyping was 46,XY.WES revealed a transversion mutation of 58T→C in the androgen receptor exon 1,which could be the pathogenic variant in this case of abnormal sexual development.Sex determination in forensic DNA typing is based on the amelogenin system.It is important that forensic biologists should master various genetic approaches to overcome the issue of gender ambiguity caused by DSDs.
基金supported by the National Key Research and Development Program of China(Grant No.SQ2017YFSF090096)the Prostate Cancer Foundation Young Investigator Award 2013+2 种基金the National Natural Science Foundation of China(Grant No.81300627,81370855,81702536,81770756)Programs from Science and Technology Department of Sichuan Province(Grant No.2018JY0089 and 2017HH0063)Young Investigator Award of Sichuan University 2017.
文摘Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue.Through interactions between chemokines and their receptors,various immune cell subsets are recruited into the tumor microenvironment which is the primary location for tumor cells interacting with responding host cells.In recent decades,a large volume of studies have revealed chemokines'role in the tumor microenviron-ment in regulating tumor growth,invasion,and/or metastasis as well as tumor immune response;however,their molecular mechanisms are not well understood.Recently,increasing evidence has reported the import-ance of the CXCL13-CXCR5 axis in the tumor microenvironment of vanious human malignancies.Thus,in this review,we will focus on the CXCL13-CXCR5 axis and elaborate on the expression patterns,regulating and cor-responding regulatory mechanisms as well as clinical values in a wide range of human cancers.
