Investigation and Hazard Assessment of Invasive Alien Plants on the Campus of Tongren University

[Objectives]The paper was to investigate and assess the species,distribution and hazard status of invasive alien plants on the campus of Tongren University.[Methods]A survey was conducted using line survey method,and the risk assessment index system of invasive alien plants was established by analytic hierarchy process(AHP).[Results]There were 11 species of invasive alien plants on the campus of Tongren University,belonging to 8 genera and 5 families.There were 6 species of invasive alien plants belonging to Asteraceae,accounting for 54.55%of the total.In terms of the origin of invasive plants,most of them were native to North America and Europe,accounting for 27.27%of the total.In terms of harmful level,there were no high-risk invasive plants on the campus of Tongren University,but Alternanthera philoxeroides had the highest score and was the most harmful.[Conclusions]The present situation of alien plant invasion on the campus of Tongren University is closely related to the ecological environment of the campus.It is suggested to strengthen the management of campus plants,focus on the prevention and control of A.philoxeroides,and carry out regular investigation of invasive alien plants on campus to ensure the ecological safety of the campus.

改性榴莲壳对染料吸附的热力学与动力学研究

以NaOH为原料对榴莲壳进行改性,用SEM及FT-IR表征其结构,考察改性榴莲壳(DRP)对罗丹明B(RhB)的吸附性能,并对吸附过程进行动力学与热力学研究。结果表明:在温度为318 K,溶液pH=3.21时,DRP对RhB的最大吸附容量可达99.88(mg·g-1);298、308和318 K三个温度下的ΔGθ分别为-2.31、-4.34和-6.41(kJ·mol-1),ΔSθ=204.98(J·mol-1·K-1),ΔHθ=58.77(kJ·mol-1);吸附过程可用拟二级动力学模型来描述,符合Langmuir等温线模型;DRP可作为吸附材料用于治理含罗丹明B的染料废水。

Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery

Circular RNAs (circRNAs) are generated by head-to-tail splicing and are ubiquitously expressed in all multicellular organisms. Their important biological functions are increasingly recognized. Cerebral ischemia reperfusion injury-induced brain microvascular endothelial cell dysfunction is an initial stage of blood-brain barrier disruption. The expression profile and potential function of circRNAs in brain microvascular endothelial cells is unknown. Rat brain microvascular endothelial cells were extracted and cultured in glucose-free medium for 4 hours with 5% CO2 and 95% N2, and the medium was then replaced with complete growth medium for 6 hours. The RNA in these cells was then extracted. The circRNA was identified by Find_circ and CIRI2 software. Functional and pathway enrichment analysis of genes that were common to differentially expressed mRNAs and circRNA host genes was performed by the Database for Annotation, Visualization and Integrated Discovery Functional Annotation Tool. Miranda software was used to predict microRNAs that were potentially sponged by circRNAs. Furthermore, cytoscape depicted the circR-NA-microRNA interaction network. The results showed that there were 1288 circRNAs in normal and oxygen-glucose deprived/recovered primary brain microvascular endothelial cells. There are 211 upregulated and 326 downregulated differentially expressed circRNAs. The host genes of these differentially expressed circRNAs overlapped with those of differentially expressed mRNAs. The shared genes were further studied by functional enrichment analyses, which revealed that circRNAs may contribute to calcium ion function and the cyclic guanosine 3′,5′-monophosphate (CAMP) dependent protein kinase (PKα) signaling pathway. Next, quantitative reverse transcription polymerase chain reaction assays were performed to detect circRNA levels transcribed from the overlapping host genes. Eight out of the ten circRNAs with the highest fold-change identified by sequencing were successfully verified. Subsequently, the circRNA-microRNA interaction networks of these eight circRNAs were explored by bioinformatic analysis. These results demonstrate that altered circRNAs may be important in the pathogenesis of cerebral ischemia reperfusion injury and consequently may also be potential therapeutic targets for cerebral ischemia diseases. All animal experiments were approved by the Chongqing Medical University Committee on Animal Research, China (approval No. CQMU20180086) on March 22, 2018.

Research progress of local characteristic drugs for treatment of rheumatoid arthritis in Xinjiang

Rheumatoid arthritis(RA)is a systemic autoimmune disease characterized by synovitis.This disease tends to recur,persist,and is difficult to cure.The pathogenesis of RA is complex.Currently,the commonly used treatments for RA—non-steroidal anti-inflammatory drugs(NSAIDs),disease-modifying anti-rheumatic drugs(DMARDs),glucocorticoids,and immunosuppressants—have notable side effects with long-term use and may be ineffective for some patients.Therefore,it is crucial to find drugs with limited side effects and significant curative effects.Xinjiang's local characteristic drugs have a long history,abundant resources,and are known for their safety and effectiveness in treating RA.In recent years,many studies have reported on the mechanisms of action and therapeutic effects of Xinjiang's local characteristic drugs on RA.This article reviews the pathogenesis of RA,as well as the research progress and treatment characteristics of Xinjiang-featured drugs.

Cause of postprandial vomiting-a giant retroperitoneal ganglioneuroma enclosing large blood vessels: A case report

BACKGROUND Ganglioneuroma (GN) is a rare neurogenic tumor that accounts for about 0.1%- 0.5% of all tumors of the nervous system.It originates from neural crest cells.GN has no specific clinical symptoms or laboratory findings,which leaves it easily overlooked and misdiagnosed as other tumors.Retroperitoneal GN with very large volume and vascular penetration is extremely rare.CASE SUMMARY We present the imaging and pathological findings of a giant retroperitoneal GN in a child.A 4-year-old boy had suffered from postprandial vomiting for more than 6 mo with no precipitating factors.Abdominal computerized tomographic examination showed a giant cystic mass in the retroperitoneal area.After injection of contrast agent,the mass showed heterogeneous enhancement.Surgery with local excision of the mass was performed to address the embedded abdominal blood vessels,and the histopathological and immunohistochemical diagnosis of the mass was GN.Postprandial vomiting was relieved,and no complications occurred after the operation.CONCLUSION In the diagnosis of giant retroperitoneal hypodense masses in children,GN should be considered if the mass presents delayed enhancement,punctate calcification,and vascular embedding but no invasion.Pathology is the golden standard for the diagnosis of GN,and surgical excision is the optimal treatment for GN.

ATP binding cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia

Purpose: In acute lymphoblastic leukemia (ALL), multidrug resistance is often mediated by AT- Pase Binding Cassette (ABC) proteins, which principally involve ABCC1 (multidrug resistance protein 1, MRP1) and ABCB1 (multidrug resistance 1, MDR1). However, direct comparisons between the differential effects of ABCC1 and ABCB1 have been difficult, since identical cell lines with differential expression of these transporters have not been developed. Experimental Design: In this study, we developed and compared the biological profiles of Jurkat cell lines that selectively over-expressed ABCC1 and ABCB1. Vincristine (VCR) plays an important role in the treatment of T-lineage ALL (T-ALL), and is often the first drug given to newly-diagnosed patients. Because of its importance in treatment, we provide descalating, sub-lethal doses of VCR to Jurkat cells, and extended our observations to expression profiling of newly diagnosed patients with T-ALL. Results: We found that VCR-resistant cells over-expressed ABCC1 nearly 30-fold. The calcein AM assay confirmed that VCR-resistant cells actively extruded VCR, and that ABCC1-mediated drug resistance conferred a different spectrum of multidrug resistance than other T-ALL induction agents. siRNA experiments that blocked ABCC1 export confirmed that VCR resistance could be reversed in vitro. Analyses of T-lymphoblasts obtained from 100 newly diagnosed T-ALL patients treated on Children’s Oncology Group Phase III studies 9404 and AALL0434 that induction failure could be could be partially explained by the over-expression of ABCC1 and ABCB1. Conclusions: Taken together, these results suggest that over-expression of ABC transporters plays a contributing role in mediating treatment failure in T-ALL, and underscore the need to employ alternate treatment approaches in patients for whom induction failed or for those with relapsed disease.

Data mining analysis of Professor Liu Shangyi＇s prescription characteristics in clinical medicine for the treatment of cancer patients with stomachache

目的：分析国医大师刘尚义教授治疗肿瘤患者胃痛的临床用药特点.方法：收集2014年1月到2016年7月就诊于刘尚义教授国医堂门诊癌症见胃痛的患者资料,采用关联规则阿Apriori算法、复杂系统熵聚类等无监督数据挖掘方法,探讨刘尚义教授治疗肿瘤患者胃痛的临床用药特点.结果：对筛选出的120例处方进行分析,确定处方中药物使用频次,药物之间的关联规则,挖掘出4个核心组合和2个新方.治疗后的胃痛症状分级明显低于治疗前,差异具有统计学意义（P〈0.001）.结论：刘教授治疗肿瘤患者胃痛以活血散结、祛湿止痛为主.

Access block and prolonged length of stay in the emergency department are associated with a higher patient mortality rate

Access block,known as exit block or boarding,is defined as a situation in which patients who are admitted or planned for admission remain in the emergency department(ED)as they are unable to be transferred to an inpatient unit within a reasonable time frame(no longer than 8 hours).[1,2]Access block often occurs due to insufficient hospital capacity and is a major issue in emergency medicine.[3]

Pharmacological intervention of traditional Chinese medicine for the quality of life in patients with colorectal cancer： a systematic review and meta-analysis

目的：评价不同中医药方法对结直肠癌患者生活质量的影响.方法：从Cochrane,Pubmed,Embase,Medline和Web of Science数据库中筛选随机对照试验来进行系统研究,并由两名评审员独立提取数据,使用软件ReviewManager5.3进行数据处理.结果：共有18个合格研究,1312名患者被纳入.实验组采用中医药结合西医治疗,或单纯中医药治疗;对照组采用西医治疗.结果显示：（1）实验组与对照组近期有效率比较,差异不具有统计学意义【P=0.06,0R=1.38,95%CI=（0.98,1.95）】.（2）实验组的KPS评分高于对照组【P〈0.001,WMD=9.60,95%CI=（5.62,13.57）】.（3）实验组与对照组毒副反应比较：实验组白细胞下降,血小板减少,恶心呕吐,腹泻,神经毒性不良反应的发生率均低于对照组【P〈0.001,OR=0.31,95%CI=（0.19,0.50）】,【P=0.003,OR=0.49,95%CI=（0.31,0.78）】,【P〈0.001,OR=0.30,95%CI=（0.16,0.54）】,【P〈0.001,OR=0.40,95%CI=（0.27,0.58）】和【P〈0.001,OR=0.43,95%CI=（0.30,0.61）】.（4）实验组与对照组免疫学检测比较：实验组的CD3,CD4,和CD4/CD8的均值均高于对照组【P〈0.001,MD=5.55,95%CI=（4.83,6.28）】,[P〈0.001,MD=6.75,95%CI=（5.25,8.26）】,[P=0.001,MD=0.26,95%CI=（0.10,0.41）】.结论：中医药对结直肠癌患者的近期临床有效率作用不显著,但可提高患者的KPS评分,缓解化疗的毒副作用,调节自身免疫,改善患者的生活质量.

Comment on“Comparison of different versions of the quick sequential organ failure assessment for predicting in-hospital mortality of sepsis patients”

Dear editor,We have read with great interest the recent article“Comparison of different versions of the quick sequential organ failure assessment for predicting in-hospital mortality of sepsis patients:A retrospective observational study”.[1]They showed that the performance of the procalcitonin-enhanced qSOFA(PqSOFA)was similar to that of the qSOFA,and the lactate-enhanced qSOFA(LqSOFA)and the modified qSOFA(MqSOFA)were superior to the qSOFA for predicting in-hospital mortality.Further,they suggested that the MqSOFA should be a candidate for the qSOFA in the emergency department(ED).We congratulate the authors for their contributions.However,we has several concerns about this research.

Trehalose ameliorates autophagy dysregulation in aged cortex and acts as an exercise mimetic to delay brain aging in elderly mice

Exercise is recognized as an effective strategy to delay brain aging, which is related to the activation of autophagy. Trehalose is a natural compound that can activate autophagy and exert beneficial effects in delaying brain aging. In this study, we investigated whether trehalose may exert neuroprotection similar to those of exercise in delaying age-related cognitive decline. Fifteen-month-old male C57BL/6 mice underwent swim exercise and/or were treated with 2% trehalose for 12 weeks. Trehalose, exercise and the combination of exercise and trehalose intervention improved the learning and memory of aged mice. They also improved the ratio of LC3-II/LC3-I, the protein level of LC3-II, Bnip3L, and Parkin respectively. Additionally, both exercise and trehalose increased the phosphorylation of AMPK. Exercise decreased cortical phosphorylation of m TOR and S6k, whereas trehalose did not change these cortical levels. These data indicated that exercise and trehalose might modulate autophagy through m TOR-dependent or m TOR-independent pathways, respectively. However, a combination of exercise and trehalose did not play a synergistic role in improving cognitive function and modulation of autophagy. Taken together, our findings suggest that trehalose exerts similar effects to those of exercise in delaying age-related cognitive decline and that it may thus represent an exercise mimetic to delay brain aging.

单层皮肌瓣入路小曲率钛网植入在颅骨修补术中的应用

目的分析单层皮肌瓣入路小曲率钛网植入在颅骨修补术中的应用效果。方法回顾性分析2018-05—2022-05行颅骨修补术的60例患者,其中观察组30例采用单层皮肌瓣入路小曲率钛网植入,常规组30例采用常规颞肌下钛网植入。比较2组患者的手术时间、切口缝合张力、切口拆线时间、切口愈合等级、钛网周围积液、钛网外露、额纹消失、颞肌萎缩、咀嚼乏力情况。结果与常规组比较,观察组切口缝合张力小,拆线时间缩短,切口愈合更佳,差异有统计学意义(P<0.05);观察组术后钛网周围积液、钛网外露、额纹消失、颞肌萎缩、咀嚼乏力总体并发症较常规组少,差异有统计学意义(P<0.05)。结论单层皮肌瓣入路小曲率钛网植入可减小切口缝合张力,术后手术部位皮瓣厚实,切口愈合更佳,钛网两侧组织与钛网良好贴合,避免钛网周围积液和钛网外露并发症,并有效保护面神经颞支和颞肌功能,避免额纹消失、颞肌萎缩、咀嚼乏力等并发症。

The difference of clinical characteristics of patients with COVID-19 in Fourth-tier city and Wuhan

Objective:This study mainly analyzed the clinical characteristics of patients with COVID-19 in Suining,one of China’s fourth-tier cities,and Wuhan and compared data between the 2 cities.Methods:A retrospective analysis of the clinical data of 68 patients with COVID-19 diagnosed at Wuhan Red Cross Hospital and 17 patients diagnosed at Suining Central Hospital,was conducted.Results:Among the 68 patients with COVID-19 in Wuhan,30(44.1%)had hypertension,and 25(36.8%)had diabetes.Three out of the 17 patients in Suining(17.6%)had hypertension,and 2 patients(11.8%)had diabetes.In the clinical classification,there were 1(5.9%)and 23(33.8%)patients with severe COVID-19 in Suining and Wuhan,respectively.Chest CT showed that lung consolidation occurred in 2(11.8%)and 26(38.2%)patients with COVID-19 in Suining and Wuhan,respectively.The proportion of patients with diabetes or hypertension,severe COVID-19,lung consolidation in Wuhan was significantly higher than that in Suining.The laboratory tests suggested that percentage of elevated C-reactive protein(CRP)(58.8%),ALT(33.8%),blood glucose(45.6%),creatine kinase(CK)(33.8%)or D-dimer(47.1%)of patients in Wuhan were significantly increased than those in Suining(29.4%,5.9%,17.6%,5.9%,and 17.7%,respectively).Conclusion:The incidence of COVID-19 in fourth-tier city and the disease severity were significantly lower than that in Wuhan.

IPMSM自适应超螺旋滑模永磁磁链观测器设计与研究

针对传统滑模磁链观测器(SMO)观测内置式永磁同步电机磁链容易受参数变化而出现观测误差的问题,以定子电流作为状态方程,构建一种自适应超螺旋滑模观测器(STA-SMO)。通过滑模等值理论对永磁磁链进行重构,实现永磁磁链的在线辨识,通过Lyapunov函数推导出定子电阻自适应律。结果表明:所设计的自适应STA-SMO相较于传统SMO,克服了电阻参数变化对磁链观测的影响,有效抑制了抖振,提高了辨识精度。

谷氨酰胺缺乏诱导CD8^(+)T细胞铁死亡促进肿瘤生长

目的探究谷氨酰胺(glutamine,Gln)对CD8^(+)T细胞抗肿瘤免疫反应的影响及机制。方法TCGA数据库分析肿瘤Gln代谢与浸润CD8^(+)T细胞数量及功能的关系。利用CRISPR/Cas9敲低MC38细胞GLS表达,构建小鼠肿瘤模型。流式细胞术检测肿瘤增殖和凋亡,分析肿瘤浸润免疫细胞数量和功能。用Gln缺乏的培养基、完全培养基或添加GSH、RSL3的培养基分别处理CD8^(+)T细胞,检测GSH含量,细胞凋亡,GPX4和Lipid-ROS及效应功能蛋白表达,并进行RNA-seq分析。结果肿瘤Gln代谢与肿瘤浸润CD8^(+)T细胞数量和功能负相关。敲低MC38细胞GLS表达抑制了C57BL/6肿瘤的生长及Ki67的表达,促进了Caspase3表达,提高了肿瘤浸润免疫细胞的数量,抑制了肿瘤浸润CD8^(+)T细胞PD-1、TIM-3和LAG-3表达,并提高了CD8^(+)T细胞CD137、CD107a、IFN-γ及TNF-α表达。RNA-seq结果显示,Gln缺乏后CD8^(+)T细胞铁死亡相关基因TFRC、HMOX1、CYBB、SLC7A11表达上调。Gln缺乏后CD8^(+)T细胞死亡增多、CD137、CD107a、IFN-γ、GSH和GPX4表达下调,Lipid-ROS表达上调;补充GSH后CD8^(+)T细胞GPX4上调,Lipid-ROS下调,CD8^(+)T细胞分泌的IFN-γ增多。结论Gln缺乏诱导CD8^(+)T细胞铁死亡抑制其效应功能。

大数据时代高校学生事务管理专业化发展策略研究

学生事务管理是高校管理工作的一个重要组成部分。目前,大数据正在转变传统的教育教学模式,也为学生事务管理提供了新的思路和方法。在教育高质量发展需求的指导下,高校学生事务管理理应契合时代发展需求,将大数据技术与学生事务管理融合,这有利于提高高校服务育人的质量,推动高校事务管理的专业化,促进新时代高校自身的建设。面对大数据提供的机遇与挑战,高校应采取积极的应对策略,构建以学生为主的信息平台,为学生管理提供依据、革新教育方式、精准化服务学生、对学生数据所呈现的问题及时提供反馈、全方面掌握学生事务管理等,以推动学生事务管理的专业化发展。

基于改进型SVPWM滞环控制并网逆变器优化研究

永磁驱动系统采用直流端并网回馈时,针对并网逆变器对瞬态能量回馈时直流母线电压骤升较大,并网电流谐波畸变率高,采用传统双闭环PI控制策略无法获得理想效果。为此结合SVPWM和滞环控制的优点,提出了一种改进型并网逆变器SVPWM滞环控制策略,有效抑制了直流母线泵升电压峰值,降低了并网电流谐波畸变率,仿真验证了控制策略正确性。

Experiment Study on the Exhaust-Gas Heat Exchanger for Small and Medium-Sized Marine Diesel Engine

This paper aims to design a special exchanger to recover the exhaust gas heat of marine diesel engines used in small and medium-sized fishing vessels,which can then be used to heat water up to 55°C–85°C for membrane desalination devices to produce fresh water.A new exhaust-gas heat exchanger of fins and tube,with a reinforced heat transfer tube section,unequal spacing fins,a mixing zone between the fin groups and four routes tube bundle,was designed.Numerical simulations were also used to provide reference information for structural design.Experiments were carried out for exhaust gas waste heat recovery from a marine diesel engine in an engine test bench utilizing the heat exchanger.The experimental results show that the difference between heat absorption by water and heat reduction of exhaust gas is less than 6.5%.After the water flow rate was adjusted,the exhaust gas waste heat recovery efficiency was higher than 70%,and the exhaust-gas heat exchanger’s outlet water temperature was 55°C–85°C at different engine loads.This means that the heat recovery from the exhaust gas of a marine diesel engine meets the requirement to drive a membrane desalination device to produce fresh water for fishers working in small and medium-sized fishing vessels.

海上油田外输天然气品质提升的实验与探究

某油田作为区域天然气外输的枢纽平台,肩负着区域天然气处理外输、轻烃处理外输的艰巨任务。但在外输燃气品质方面存在着露点波动大、轻烃含水以及硫化氢超标等诸多问题,经过现场调查后,对于一系列的影响因素进行了提取实验分析,最终确定了设备结构不合理、燃气温度设定不符合现场工况需求、SRB滋生等关键性原因,随即现场进行了针对性的流程改造及适应性调整,最终将燃气露点稳定在-28℃~-30℃,三甘醇没有再出现异常消耗的情况,外输轻烃含水明显下降,品质明显提升。另外,经过化学药剂的选型干预,显著降低了流程细菌数量和硫化氢含量,外输天然气品质有了质的提升,该项目的实施产生了巨大的经济效益和环保效益,并对海上油田同类型的问题解决提供了参考借鉴和指导价值。