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脂质纳米颗粒递送mRNA在疾病防治中的应用
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作者 孙伟伦 周悌强 +5 位作者 杨海银 李路伟 翁郁华 张金超 黄渊余 梁兴杰 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2024年第10期2677-2693,共17页
近年来,信使核糖核酸(messenger RNA,mRNA)疗法作为一种革命性的治疗手段,在遗传性疾病、传染病以及癌症治疗领域展现出巨大潜力。然而,mRNA分子的不稳定性和体内递送的低效性仍是限制其广泛应用的关键挑战。本综述聚焦于脂质纳米颗粒(l... 近年来,信使核糖核酸(messenger RNA,mRNA)疗法作为一种革命性的治疗手段,在遗传性疾病、传染病以及癌症治疗领域展现出巨大潜力。然而,mRNA分子的不稳定性和体内递送的低效性仍是限制其广泛应用的关键挑战。本综述聚焦于脂质纳米颗粒(lipid nanoparticles,LNPs)作为高效载体在mRNA递送系统中的最新进展与应用,系统地概述了mRNA治疗在疫苗、蛋白质替代疗法和基因编辑治疗中的应用,并基于LNP基础四组分的改造、第五组分的引入、表面改性以及机器学习辅助LNP迭代开发等四个方面,详细介绍了工程化修饰LNP的方式以及在治疗中的应用。 展开更多
关键词 脂质纳米颗粒 MRNA 工程化 靶向性
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Active tectonic deformation and its seismic-geological signifi cance of boundary faults of the Daxing Uplift and Langgu-Dachang Depression,Beijing Plain,China
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作者 Zheng Rong-Ying Yu Zhong-Yuan +2 位作者 Chen Bai-Xu li lu-wei and Wang Yi-Cheng 《Applied Geophysics》 SCIE 2024年第4期715-727,879,共14页
Boundary faults of the Daxing Uplift and Langgu-Dachang Depression are located in the southeastern region of the Beijing Plain and directly control the sedimentation,tectonic evolution,and strong seismic activity of t... Boundary faults of the Daxing Uplift and Langgu-Dachang Depression are located in the southeastern region of the Beijing Plain and directly control the sedimentation,tectonic evolution,and strong seismic activity of the plain.The Sanhe-Pinggu earthquake of Ms 8.0 occurred in 1679,but the active tectonic deformation characteristics of the boundary have been rarely discussed.In this study,the active tectonic deformation characteristics of the Daxing Uplift and Langgu-Dachang Depression boundary rupture were investigated by collecting and analyzing the results of previous works,supplementing three shallow-seismicexploration control lines at locations where the data are lacking,and carrying out borehole combined profi le exploration and optically stimulated luminescence dating at local breakpoints.Results show that the Daxing Uplift and Langgu-Dachang Depression boundary faults constitute an active tectonic deformation zone with~50 km distance between Mafang and Niubaotun towns and then extends to both ends to form a deep and large fault that cuts through the earth’s crust.The activity of the Daxing Uplift eastern boundary fault may be divided into two sections near Anding town,with the early-to-middle Late Pleistocene gradually weakening in the northwest and the Holocene gradually weakening in the southwest.Moreover,the activity of the Xiadian fault may be divided into two sections near the Chaobai River:the Holocene gradually weakening in the northwest and the early-to-middle Late Pleistocene gradually weakening in the southwest.The boundary fault of the Daxing Uplift and Langgu-Dachang Depression has an~43 km seismic gap around Niubaotun town,which has a high risk of Ms 6.0-7.0 earthquakes.This investigation into the active tectonic deformation characteristics of the boundary fault of the Daxing Uplift and Langgu-Dachang Depression is crucial for analyzing the strong earthquake rupture behavior and the future risk of strong earthquakes in this area.It also contributes greatly to the study of the tectonic pattern evolution of the North China Plain and Beijing Plain. 展开更多
关键词 Daxing uplift Langgu-Dachang depression Active tectonic deformation Late Quaternary Strong earthquake risk
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