OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHO...OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHODS:A total of 62 patients(124 eyes) with dry eye syndrome treated in the Department of Ophthalmology of The 4th People's Hospital of Shenyang from July 2017 to March 2018 were selected and equally divided into 2 groups according to the admission order. The observation group received the combination therapy of TCM decoction and ear acupoint application, while the control group was given the simple artificial tears. The symptom score after 2 weeks, 4 weeks, and 8 weeks as well as the indicators including break-up time(BUT), Schirmer I test(SIT) and fluorescein(FL) were recorded and compared between groups. RESULTS: The symptom scores had no difference before treatment(P > 0.05), and were better in the observation group than those in the control group after treatment(P < 0.05). At 2 weeks, 4 weeks, and 8 weeks after the treatment, the amelioration level of BUT, SIT, and FL indicators in the observation group was better than that of the control group(P < 0.05). CONCLUSION: Compared with the artificial tears treatment method, the TCM decoction combined with ear acupoint application can significantly ameliorate the tear film stability, tear secretion, and reduce ocular surface damage for dry eye patients.展开更多
OBJECTIVE: To study the effect of Erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitte...OBJECTIVE: To study the effect of Erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitted to our hospital from May 2017 to May 2018 were selected. They were randomly divided into the study group and the control group. The control group was treated with oral vitamin C and vitamin E while study group was treated with Erzhi Mingmu Decoction based on the same treatment of the control group. Both groups were continuously treated for 1 month, the visual improvement, fundus changes, and changes of serum VEGF and CRP levels were compared before and after treatment. RESULTS: The number of patients with visual improvement was higher in the study group than that in the control group(P < 0.05). The number of patients with fundus improvement in the study group was more than that of the control group(P < 0.05). Serum VEGF levels were decreased in the 2 groups after treatment, and they were decreased more in the study group than those in control group(all P < 0.05). Serum CRP levels were decreased in the 2 groups after treatment, and the serum CRP levels were decreased more in the study group than those in control group(all P < 0.05). CONCLUSION: The treatment of non-exudative age-related macular degeneration with Erzhimingmu Decoction can significantly improve the vision of patients, improve the condition of the fundus, and reduce the levels of serum VEGF and CRP, which is worthy of clinical promotion and application.展开更多
目的本研究运用两样本孟德尔随机化(mendelian randomization,MR)研究来揭示失眠与抑郁症之间的双向因果关系,为失眠和抑郁症的预防提供新思路。方法本研究基于欧洲人群失眠和抑郁症的大型全基因组关联分析(genome-wide association stu...目的本研究运用两样本孟德尔随机化(mendelian randomization,MR)研究来揭示失眠与抑郁症之间的双向因果关系,为失眠和抑郁症的预防提供新思路。方法本研究基于欧洲人群失眠和抑郁症的大型全基因组关联分析(genome-wide association study,GWAS)汇总数据(样本量分别为453379人和250215人),利用两样本MR研究,将遗传因素作为工具变量,分析失眠与抑郁症之间的双向因果关系。结果研究结果显示失眠会导致患抑郁症的风险升高,失眠人群患有抑郁症的风险是正常人群的1.757倍(OR=1.757,P<0.001);抑郁症对失眠的效应不显著(OR=1.044,P=0.086)。结论失眠会导致患抑郁症风险升高,而抑郁症对失眠的效应不显著。因此可以对失眠人群进行干预,降低其患抑郁症的风险。展开更多
以多年生草本黑麦草为对象,模拟喀斯特生境土壤特征设置浅而宽(Shallow and wide,SW:30×30×5 cm^3)和深而窄(Deep and narrow,DN:10×10×45 cm^3)两种土壤容器,以正常降水量为对照供水(W100%),设减水50%(W50%)和减水...以多年生草本黑麦草为对象,模拟喀斯特生境土壤特征设置浅而宽(Shallow and wide,SW:30×30×5 cm^3)和深而窄(Deep and narrow,DN:10×10×45 cm^3)两种土壤容器,以正常降水量为对照供水(W100%),设减水50%(W50%)和减水70%(W30%)共3种水分处理进行盆栽实验,探究了两种不同土壤生境中土壤水分变化对黑麦草生长及光合生理的影响,以进一步理解喀斯特地区植物的适应对策。结果显示:(1)SW生境对水分变化敏感,随供水减少土壤含水量显著下降。轻度减水下植物叶面积增大,光合速率提高,地上部分生长得到促进,但水分严重减少对其生长和光合生理有抑制作用,但地上质量分数和水分利用效率却显著升高;(2)DN生境保水能力较好,随供水减少土壤水分含量下降较为平缓。叶片相对含水量、气孔导度和比叶面积在各水分处理之间差异不显著,但严重减水条件下总生物量、地上质量分数和水分利用效率均有回升。研究表明:浅而宽生境中植物倾向于通过提高地上部分的生长,保持较高的光合速率,并向地上部分分配较多生物量来应对水分胁迫;而深而窄生境中植物会充分利用土壤空间条件,促进根系的生长来提高对水分的吸收,从而维持植物的生长。展开更多
为了提取到更加准确、丰富的叶片病斑的颜色特征和空间特征,解决病害严重程度细粒度分类粗糙、识别准确率低等问题,提出一种融合颜色掩膜网络和自注意力机制(Fusion color mask and self-attention network,FCMSAN)的病害识别方法。FCM...为了提取到更加准确、丰富的叶片病斑的颜色特征和空间特征,解决病害严重程度细粒度分类粗糙、识别准确率低等问题,提出一种融合颜色掩膜网络和自注意力机制(Fusion color mask and self-attention network,FCMSAN)的病害识别方法。FCMSAN由颜色掩膜网络(Color mask network,CMN)和融合通道自适应的自注意力网络(Channel adaptive self-attention network,CASAN)构成。CMN通过学习叶片病斑颜色区域信息提高模型提取颜色特征的能力;CASAN能够提取全局范围内的病斑特征,同时加入病斑的位置特征和通道自适应特征,可以精确、全面定位叶片病斑区域。最后通过特征转换融合模块(Transfer fusion layer,TFL)将CMN和CASAN进行融合。经实验证明,FCMSAN在61类农作物病虫害细粒度识别中,Top-1的分类准确率达到87.97%,平均F1值达到84.48%。最后通过可视化分析,验证了本文方法在病害识别中的有效性。展开更多
文摘OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHODS:A total of 62 patients(124 eyes) with dry eye syndrome treated in the Department of Ophthalmology of The 4th People's Hospital of Shenyang from July 2017 to March 2018 were selected and equally divided into 2 groups according to the admission order. The observation group received the combination therapy of TCM decoction and ear acupoint application, while the control group was given the simple artificial tears. The symptom score after 2 weeks, 4 weeks, and 8 weeks as well as the indicators including break-up time(BUT), Schirmer I test(SIT) and fluorescein(FL) were recorded and compared between groups. RESULTS: The symptom scores had no difference before treatment(P > 0.05), and were better in the observation group than those in the control group after treatment(P < 0.05). At 2 weeks, 4 weeks, and 8 weeks after the treatment, the amelioration level of BUT, SIT, and FL indicators in the observation group was better than that of the control group(P < 0.05). CONCLUSION: Compared with the artificial tears treatment method, the TCM decoction combined with ear acupoint application can significantly ameliorate the tear film stability, tear secretion, and reduce ocular surface damage for dry eye patients.
基金funded by the Natural Science Foundation of Liaoning Province (Project No.:20170520009)
文摘OBJECTIVE: To study the effect of Erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitted to our hospital from May 2017 to May 2018 were selected. They were randomly divided into the study group and the control group. The control group was treated with oral vitamin C and vitamin E while study group was treated with Erzhi Mingmu Decoction based on the same treatment of the control group. Both groups were continuously treated for 1 month, the visual improvement, fundus changes, and changes of serum VEGF and CRP levels were compared before and after treatment. RESULTS: The number of patients with visual improvement was higher in the study group than that in the control group(P < 0.05). The number of patients with fundus improvement in the study group was more than that of the control group(P < 0.05). Serum VEGF levels were decreased in the 2 groups after treatment, and they were decreased more in the study group than those in control group(all P < 0.05). Serum CRP levels were decreased in the 2 groups after treatment, and the serum CRP levels were decreased more in the study group than those in control group(all P < 0.05). CONCLUSION: The treatment of non-exudative age-related macular degeneration with Erzhimingmu Decoction can significantly improve the vision of patients, improve the condition of the fundus, and reduce the levels of serum VEGF and CRP, which is worthy of clinical promotion and application.
文摘目的本研究运用两样本孟德尔随机化(mendelian randomization,MR)研究来揭示失眠与抑郁症之间的双向因果关系,为失眠和抑郁症的预防提供新思路。方法本研究基于欧洲人群失眠和抑郁症的大型全基因组关联分析(genome-wide association study,GWAS)汇总数据(样本量分别为453379人和250215人),利用两样本MR研究,将遗传因素作为工具变量,分析失眠与抑郁症之间的双向因果关系。结果研究结果显示失眠会导致患抑郁症的风险升高,失眠人群患有抑郁症的风险是正常人群的1.757倍(OR=1.757,P<0.001);抑郁症对失眠的效应不显著(OR=1.044,P=0.086)。结论失眠会导致患抑郁症风险升高,而抑郁症对失眠的效应不显著。因此可以对失眠人群进行干预,降低其患抑郁症的风险。
文摘以多年生草本黑麦草为对象,模拟喀斯特生境土壤特征设置浅而宽(Shallow and wide,SW:30×30×5 cm^3)和深而窄(Deep and narrow,DN:10×10×45 cm^3)两种土壤容器,以正常降水量为对照供水(W100%),设减水50%(W50%)和减水70%(W30%)共3种水分处理进行盆栽实验,探究了两种不同土壤生境中土壤水分变化对黑麦草生长及光合生理的影响,以进一步理解喀斯特地区植物的适应对策。结果显示:(1)SW生境对水分变化敏感,随供水减少土壤含水量显著下降。轻度减水下植物叶面积增大,光合速率提高,地上部分生长得到促进,但水分严重减少对其生长和光合生理有抑制作用,但地上质量分数和水分利用效率却显著升高;(2)DN生境保水能力较好,随供水减少土壤水分含量下降较为平缓。叶片相对含水量、气孔导度和比叶面积在各水分处理之间差异不显著,但严重减水条件下总生物量、地上质量分数和水分利用效率均有回升。研究表明:浅而宽生境中植物倾向于通过提高地上部分的生长,保持较高的光合速率,并向地上部分分配较多生物量来应对水分胁迫;而深而窄生境中植物会充分利用土壤空间条件,促进根系的生长来提高对水分的吸收,从而维持植物的生长。
