As a necessary step toward the quantitative predictions of macro-segregation commonly found in metal castings,classical experiments and numerical benchmarks have been used to validate a simplified binary- alloy solidi...As a necessary step toward the quantitative predictions of macro-segregation commonly found in metal castings,classical experiments and numerical benchmarks have been used to validate a simplified binary- alloy solidification model.The model consists of fully coupled conservation equations for the transport phenomena (heat transfer,solute redistribution,and melt convection)that lead to macro-segregation in a solidifying ingot with a fixed solid phase.Simulations were performed for solidification of either a Pb-48wt.%Sn or a Sn-5wt.%Pb alloy in a rectangular cavity.The present predictions were compared with experimental data and numerical reference results reported in the literature.Subsequently,the model was applied to a numerical benchmark problem described in the literature for solidification of a Sn-10wt.%Pb alloy.Simulation results for flow velocity,liquid fraction evolution,and macro-segregation maps also were compared with literature predictions,showing similar trends.It is concluded that additional comparisons to experimental results are still required to assess more complex solidification models.展开更多
The basal ganglia is a critical subcortical nuclei in several parallel and closed circuits,which mainly modulate thalamus-cortex activity.Dysfunction in any one of these loops connecting cortex can lead to movement an...The basal ganglia is a critical subcortical nuclei in several parallel and closed circuits,which mainly modulate thalamus-cortex activity.Dysfunction in any one of these loops connecting cortex can lead to movement and/or mood disorders.To understand cellular complexity,differential gene expression and transcriptional regulatory network of human basal ganglia under normal condition,we performed single cell RNA sequencing of 2424 cells sampled from the basal ganglia of human postmortem brains including caudate,putamen,substantia nigra and globus pallidus.展开更多
基金supported by the National Science and Technology Major Project of China(No.2011ZX04014-052)the National Basic Research Program of China(No.2011CB012900)
文摘As a necessary step toward the quantitative predictions of macro-segregation commonly found in metal castings,classical experiments and numerical benchmarks have been used to validate a simplified binary- alloy solidification model.The model consists of fully coupled conservation equations for the transport phenomena (heat transfer,solute redistribution,and melt convection)that lead to macro-segregation in a solidifying ingot with a fixed solid phase.Simulations were performed for solidification of either a Pb-48wt.%Sn or a Sn-5wt.%Pb alloy in a rectangular cavity.The present predictions were compared with experimental data and numerical reference results reported in the literature.Subsequently,the model was applied to a numerical benchmark problem described in the literature for solidification of a Sn-10wt.%Pb alloy.Simulation results for flow velocity,liquid fraction evolution,and macro-segregation maps also were compared with literature predictions,showing similar trends.It is concluded that additional comparisons to experimental results are still required to assess more complex solidification models.
文摘The basal ganglia is a critical subcortical nuclei in several parallel and closed circuits,which mainly modulate thalamus-cortex activity.Dysfunction in any one of these loops connecting cortex can lead to movement and/or mood disorders.To understand cellular complexity,differential gene expression and transcriptional regulatory network of human basal ganglia under normal condition,we performed single cell RNA sequencing of 2424 cells sampled from the basal ganglia of human postmortem brains including caudate,putamen,substantia nigra and globus pallidus.
