Synthesis of Phenoxazinone Derivatives and Antiproliferative Activities on Wild-type and Drug-resistant Tumor Cells

A series of novel phenoxazinone derivatives （1-6） were designed and synthesized for evaluating their antitumor activities. The antiproliferative activities of the prepared compounds against representative human neoplastic cell lines were evaluated by MTF assay. The results showed that most of them inhibited cell proliferation in a submicromolar to rnicromolar range. These compounds were also evaluated against KBv200 and MCF-7/Adr cell lines, which overexpress the MDR/P-glycoprotein drug efflux pump responsible for drug resistance, and had a more potential for resisting MDR than their lead compound APO.

Design,synthesis and antitumor activity of a series of novel coumarin-stilbenes hybrids,the 3-arylcoumarins

A series of novel coumarin-stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents.The results showed that some compounds exhibited in vitro activity against KB,KV,MCF-7,MCF-7/ ADR cell lines to some extent.Compound 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18μmol/L.

布青山—巴颜喀拉地区石炭系—二叠系研究新进展

青海省布青山—巴颜喀拉地区石炭系—二叠系较为发育,前人将巴颜喀拉地区呈断块、透镜状镶嵌于巴颜喀拉山群中的基性火山岩—碳酸盐岩—碎屑岩组合,以及布青山地区以断层接触形式相互叠置在一起堆积形成的构造(蛇绿)混杂岩均划归布青山群。本文结合近些年在该地区开展的1/5万、1/25万区域地质调查和相关的科研成果等资料,重新厘定了布青山—巴颜喀拉地区的石炭系—二叠系,在布青山地区废除了“布青山群”,将其中的“马尔争组”修订为非常规地层——石炭系—中二叠统马尔争蛇绿混杂岩。在巴颜喀拉地区呈断块状产出的一套基性火山岩、碳酸盐岩和碎屑岩从“布青山群”中解体出来,新建了玛曲组,为典型的洋岛玄武岩—海山碳酸盐岩沉积建造。马尔争组和玛曲组的确立,表明石炭纪—中二叠世布青山—巴颜喀拉地区仍为相当规模的洋盆,该大洋为一个多岛洋,其中存在许多微板块、海山及洋岛。

东昆仑—柴达木地区泥盆系划分对比

东昆仑—柴达木地区泥盆系较为发育,均表现为陆相碎屑岩和火山岩沉积。前人将该地区泥盆系笼统地划归晚泥盆世牦牛山组,但其空间分布情况不详,划分与对比仍存争议。本文结合近些年在该地区开展的1/5万、1/25万区域地质调查和相关的科研成果等资料,重新厘定了东昆仑—柴达木地区泥盆系,将牦牛山组限于柴达木盆地北缘地区,代表中—晚泥盆世陆相碎屑岩-火山岩沉积;重新启用契盖苏组,代表东昆北地区早泥盆世陆相碎屑岩-火山岩沉积;新建雪水河组代表万保沟地区早泥盆世陆相碎屑岩-火山碎屑岩沉积。